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作者	单位	E-mail
王　霞	康复大学青岛中心医院（青岛市中心医院）腹部超声科山东青岛 266042	wmjh_2004@163.com
金艳青	康复大学青岛中心医院（青岛市中心医院）腹部超声科山东青岛 266042
韩　亮	康复大学青岛中心医院（青岛市中心医院）腹部超声科山东青岛 266042
于　兰	康复大学青岛中心医院（青岛市中心医院）肿瘤立体定向放疗科山东青岛 266042
梅　红	康复大学青岛中心医院（青岛市中心医院）腹部超声科山东青岛 266042

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中文摘要:

摘要目的：探讨超声造影结合血清肠三叶因子（ITF）对于非小细胞肺癌（NSCLC）的诊断价值。方法：纳入2021年1月-2023年6月在我院接受手术治疗的肺部占位患者130例作为研究对象。所有患者术前均接受超声造影检查及血清ITF检测。根据患者术后病理结果，分为NSCLC组（n＝58）和肺部良性肿瘤组（n＝72）。比较两组患者超声造影参数及血清ITF水平。绘制受试者工作特征曲线（ROC）分析超声造影参数、血清ITF及两者联合对NSCLC的诊断价值。结果：NSCLC组RT、TP、AT2和△AT均高于肺部良性肿瘤组（P＜0.05）。NSCLC组血清ITF水平高于肺部良性肿瘤组（P＜0.05）。超声造影参数行ROC曲线分析结果显示：曲线下面积（AUC）最大的为△AT，且当△AT≥3.14s时，其特异性为88.29%，对NSCLC具有较高的诊断价值。血清ITF行ROC曲线分析结果显示：AUC为0.735，且当血清ITF≥1073.82 pg/mL时，其特异性为81.06%，对NSCLC具有一定诊断价值。超声造影参数结合血清ITF行ROC曲线分析结果显示：AUC为0.916，其特异性为91.20%，对NSCLC具有最佳的诊断价值。结论：超声造影结合血清ITF对NSCLC具有较高的诊断价值，有助于肺部良恶性肿瘤的鉴别诊断，为患者的临床诊疗提供可靠的参考依据。

英文摘要:

ABSTRACT Objective: To investigate the diagnostic value of contrast-enhanced ultrasound combined with serum intestinal trefoil factor (ITF) in non-small cell lung cancer (NSCLC). Methods: From January 2021 to June 2023, 130 patients with pulmonary space-occupying lesions who underwent surgical treatment in our hospital were included as the study subjects. All patients underwent contrast-enhanced ultrasonography and serum ITF detection before operation. According to the postoperative pathological results, the patients were divided into NSCLC group (n=58) and benign lung tumor group (n=72). Contrast-enhanced ultrasound parameters and serum ITF levels were compared between the two groups. The receiver operating characteristic curve (ROC) was drawn to analyze the diagnostic value of contrast-enhanced ultrasound parameters, serum ITF and their combination for NSCLC. Results: RT, TP, AT2 and △AT in NSCLC group were higher than those in benign lung tumor group(P<0.05). The level of serum ITF in NSCLC group was higher than that in benign lung tumor group(P<0.05). The results of ROC curve analysis of contrast-enhanced ultrasound parameters showed that the largest area under the curve (AUC) was△AT, and when △AT ≥ 3.14s, its specificity was 88.29%, which had high diagnostic value for NSCLC. ROC curve analysis of serum ITF showed that AUC was 0.735, and when serum ITF≥1073.82 pg/mL, its specificity was 81.06%, which had certain diagnostic value for NSCLC. The ROC curve analysis of contrast-enhanced ultrasound parameters combined with serum ITF showed that the AUC was 0.916 and the specificity was 91.20 %, which had the best diagnostic value for NSCLC. Conclusion: Contrast-enhanced ultrasound combined with serum ITF has a high diagnostic value for NSCLC, which is helpful for the differential diagnosis of benign and malignant lung tumors, and provides a reliable reference for the clinical diagnosis and treatment of patients.

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