| 池 涛,彭 伟,杨 珍,经顺中,韦佳颖.艾司氯氨酮联合丙泊酚对肠套叠复位术患儿复位效果、应激反应和炎症因子的影响[J].,2024,(12):2387-2390 |
| 艾司氯氨酮联合丙泊酚对肠套叠复位术患儿复位效果、应激反应和炎症因子的影响 |
| Effects of Esketamine Combined with Propofol on Reduction Effect, Stress Response and Inflammatory Factors in Children Undergoing Intussusception Reduction Surgery |
| 投稿时间：2024-01-21 修订日期：2024-02-18 |
| DOI：10.13241/j.cnki.pmb.2024.12.037 |
| 中文关键词: 艾司氯氨酮 丙泊酚 肠套叠复位术 复位效果 应激反应 炎症因子 |
| 英文关键词: Esketamine Propofol Intussusception reduction surgery Reduction effect Stress response Inflammatory factors |
| 基金项目:广西壮族自治区卫生健康委自筹经费科研项目（Z-A20230372） |
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| 中文摘要: |
| 摘要 目的：观察艾司氯氨酮联合丙泊酚对肠套叠复位术患儿复位效果、应激反应和炎症因子的影响。方法：选取2022年1月-2023年8月我院收治的97例肠套叠复位术患儿。按随机数字表法分为对照组（n=48，丙泊酚治疗）和观察组（n=49，艾司氯氨酮联合丙泊酚治疗）。对比两组复位成功率、镇痛镇静评分、血清应激反应指标、血清炎症因子和不良反应发生率。结果：观察组的复位成功率明显高于对照组（P<0.05）。观察组术后6 h、术后12 h、术后24 h儿童疼痛行为量表（FLACC）评分、麻醉苏醒期躁动评分系统（Watcha）评分低于对照组（P<0.05）。观察组术后24 h去甲肾上腺素（NE）、皮质醇（Cor）、白介素-6（IL-6）、C 反应蛋白（CRP）、 肿瘤坏死因子-α（TNF-α）低于对照组（P<0.05）。观察组不良反应发生率为10.20%，对照组的为8.33%，组间对比未见差异（P>0.05）。结论：艾司氯氨酮联合丙泊酚用于肠套叠复位术患儿，可提高患儿的复位效果，减轻应激反应，降低炎症因子水平分泌，且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of esketamine combined with propofol on reduction effect, stress response and inflammatory factors in children undergoing intussusception reduction surgery. Methods: 97 children with intussusception reduction surgery who admitted to our hospital from January 2022 to August 2023 were selected, and they were divided into control group (n=48, treated with propofol treatment) and observation group (n=49, treated with esketamine combined with propofol) according to the random number table method. The success rate of reduction, analgesic sedation score, serum stress response index, serum inflammatory factors and incidence of adverse reactions were compared between two groups. Results: The success rate of reduction in observation group was significantly higher than that in control group (P<0.05). The Child Pain Behavior Scale(FLACC) score and Agitation scoring system during the awake phase of anesthesia(Watcha) score in observation group were lower than those in control group at 6 h, 12 h and 24 h after operation (P<0.05). The levels of norepinephrine (NE), cortisol (Cor), interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in observation group were lower than those in control group at 24 h after operation(P<0.05). The incidence of adverse reactions was 10.20% in observation group and 8.33% in control group, there was no difference between two groups(P>0.05). Conclusion: Esketamine combined with propofol for intussusception reduction in children, which can improve the reduction effect of children, reduce stress response, reduce the secretion of inflammatory factors, and have good safety. |
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