| 尚 倩,杨丽娟,党延玲,朱东宁,张 兰.不同严重程度儿童特应性皮炎血清半乳糖凝集素-10及炎症因子的表达水平及其与皮肤感染的相关性分析[J].,2024,(12):2306-2309 |
| 不同严重程度儿童特应性皮炎血清半乳糖凝集素-10及炎症因子的表达水平及其与皮肤感染的相关性分析 |
| Expression Levels of Serum Galectin-10 and Inflammatory Factors in Children with Atopic Dermatitis of Different Severity and Their Correlation with Skin Infection |
| 投稿时间：2023-10-09 修订日期：2023-10-31 |
| DOI：10.13241/j.cnki.pmb.2024.12.020 |
| 中文关键词: 儿童 特应性皮炎 半乳糖凝集素-10 炎症因子 皮肤屏障功能 皮肤感染 |
| 英文关键词: Children Atopic dermatitis Galectin-10 Inflammatory factors Skin barrier function Skin infection |
| 基金项目:陕西省自然科学基础研究计划项目（2021JM-267） |
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| 中文摘要: |
| 摘要 目的：分析不同严重程度儿童特应性皮炎血清半乳糖凝集素-10（Gal-10）及炎症因子的表达水平及其与皮肤感染的相关性。方法：选择我院自2022年1月至2023年1月收治的110例特应性皮炎患儿纳入观察组，根据特应性皮炎评分（SCORAD），分为轻度组、中度组和重度组；另选110例健康体检儿童纳入对照组。检测所有入选者血清Gal-10、炎症因子（IL-4、IL-13、IL-31）水平及不同部位皮肤经皮失水量，分析血清Gal-10、IL-4、IL-13、IL-31与SCORAD评分、不同部位皮肤经皮失水量的关系，使用受试者工作特征曲线（ROC）分析血清Gal-10、炎症因子（IL-4、IL-13、IL-31）对皮肤感染的预测效能。结果：观察组血清Gal-10、IL-4、IL-13、IL-31水平均高于对照组（P＜0.05）；随着儿童特应性皮炎病情加重，患儿血清Gal-10、IL-4、IL-13、IL-31水平随之升高，血清Gal-10、IL-4、IL-13、IL-31水平在轻度组、中度组和重度组中差异显著（P＜0.05）；经Pearson相关性分析，特应性皮炎患儿血清Gal-10、IL-4、IL-13、IL-31水平与SCORAD评分，前壁伸侧、前壁屈侧、脸颊及胫前的经皮失水量呈正相关（P＜0.05）；在110例特应性皮炎患儿中，发生皮肤感染43例；经ROC曲线分析，血清Gal-10、IL-4、IL-13联合IL-31预测特应性皮炎患儿发生皮肤感染的敏感度为89.72%、特异度为56.97%、ROC曲线下面积（AUC）为0.921。结论：血清Gal-10、炎症因子（IL-4、IL-13、IL-31）水平与儿童特应性皮炎严重程度有显著相关性，对于评估其皮肤屏障功能和预测皮肤感染均具有一定作用，值得临床予以重视应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression levels of serum galectin-10 (Gal-10) and inflammatory factors and their correlation with skin infection in children with atopic dermatitis of different severity. Methods: A total of 110 children with atopic dermatitis admitted to our hospital from January 2022 to January 2023 were included in the observation group. They were divided into mild group,moderate group and severe group according to SCORAD. Another 110 healthy children were included in the control group. The levels of serum Gal-10,inflammatory factors (IL-4, IL-13, IL-31) and percutaneous water loss in different parts of the skin were detected, and the relationship between serum Gal-10, IL-4, IL-13, IL-31, SCORAD score and percutaneous water loss in different parts of the skin was analyzed. The predictive efficacy of serum Gal-10 and inflammatory factors (IL-4, IL-13, IL-31) on skin infection was analyzed using receiver operating characteristic curve (ROC). Results: The levels of serum Gal-10, IL-4, IL-13 and IL-31 in observation group were higher than those in control group (P<0.05). With the aggravation of atopic dermatitis in children, serum levels of Gal-10, IL-4, IL-13 and IL-31 increased, and serum levels of Gal-10, IL-4, IL-13 and IL-31 in mild, moderate and severe groups were significantly different(P<0.05). By Pearson correlation analysis, serum Gal-10, IL-4, IL-13 and IL-31 levels were positively correlated with SCORAD score, and percutaneous water loss in anterior wall extension, anterior wall flexion, cheek and anterior tibia in atopic dermatitis children(P<0.05). Among 110 children with atopic dermatitis, 43 had skin infections. According to ROC curve analysis,the sensitivity of serum Gal-10, IL-4, IL-13 combined with IL-31 to predict skin infection in children with atopic dermatitis was 89.72%, the specificity was 56.97% and the area under ROC curve (AUC) was 0.921. Conclusion: The levels of serum Gal-10 and inflammatory factors (IL-4, IL-13, IL-31) are significantly correlated with the severity of atopic dermatitis in children, and are of certain significance in evaluating skin barrier function and predicting skin infection, which is worthy of clinical attention. |
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