| Objective: To investigate the predictive value of serum vascular endothelial growth factor receptor 2 (VEGFR2) and soluble endothelial factor (sEng) combined with uterine artery blood flow parameters [blood flow resistance index (RI), systolic/diastolic blood flow velocity ratio (S/D) , blood flow pulsation index (PI) ] for fetal growth restriction (FGR) in preeclampsia patients. Methods: 136 preeclampsia patients who were admitted in our hospital from January 2020 to September 2024 were selected. All patients underwent ultrasound examination, and uterine artery blood flow parameters were recorded. Patients were divided into FGR group (n=42) and normal group (n=94) according to whether FGR occurred, the uterine artery blood flow parameters, serum VEGFR2 and sEng levels were compared between FGR group and normal group. The correlation between uterine artery blood flow parameters and serum VEGFR2, sEng levels were analyzed. The predictive value of VEGFR2 and sEng levels combined with uterine artery blood flow parameters for FGR in preeclampsia patients were analyzed by receiver operating characteristic (ROC) curve. Results: The RI, S/D, PI in FGR group were higher than those in normal group (P<0.05). Serum sEng in FGR group was higher than that in normal group, and serum VEGFR2 was lower than that in normal group (P<0.05). Pearson correlation analysis showed that, serum VEGFR2 was negatively correlated with RI, PI and S/D, and serum sEng was positively correlated with RI, PI and S/D (P<0.05). The area under the curve (AUC) of RI, PI, S/D, VEGFR2, sEng alone and in combination were 0.792, 0.761, 0.822, 0.788, 0.887 and 0.971, respectively, the combined application had the highest predictive efficiency. Conclusion: RI, PI, S/Dcombined with serum VEGFR2 and sEng have higher predictive value for FGR in preeclampsia patients. |
