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| 脑红蛋白在蛛网膜下腔出血的研究现状和未来展望 |
| Current status and future perspectives in the study of ceruloplasmin in subarachnoid haemorrhage |
| 投稿时间：2024-11-27 修订日期：2024-11-27 |
| DOI： |
| 中文关键词: 脑红蛋白 蛛网膜下腔出血 生物学特性 缺血缺氧 神经保护 |
| 英文关键词: ceruloplasmin subarachnoid haemorrhage biological properties ischaemia-hypoxia neuroprotection |
| 基金项目:甘肃省科技计划项目（重点研发计划）Gansu Provincial Science and Technology Programme (Key R&D Programme) (21YF11FA003) ；兰州市城关区科技计划项目Lanzhou Chengguan District Science and Technology Programme（2021SHFZ0028） |
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| 中文摘要: |
| 脑红蛋白(Ngb)是一类新型氧结合球蛋白,主要存在于神经细胞中,与脑组织氧供应密切相关。蛛网膜下腔出血（SAH）能诱导Nbg的高表达，而 Ngb 作为一种内源性神经保护因子,在缺血缺氧条件下能够发挥神经保护作用,可降低缺血缺氧性脑损伤的程度。本文现围绕Ngb的结构、功能及其在SAH损伤中的神经保护作用和机制综述如下。 |
| 英文摘要: |
| Neoglobin (Ngb) is a recently identified class of oxygen-binding globulin, predominantly expressed in neuronal cells, and plays a pivotal role in maintaining the oxygen supply to brain tissue. Subarachnoid haemorrhage (SAH) has been observed to induce high expression of Ngbg. As an endogenous neuroprotective factor, Ngb can play a neuroprotective role under ischemic and hypoxic conditions, which can reduce the degree of ischemic-hypoxic brain injury. This paper will review the structure and function of Ngb and its neuroprotective effects and mechanisms in SAH injury. |
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