| 尹美娜,刘 玲,郭敬肖,韩佩桐,张东风.他克莫司联合泼尼松对原发性肾病综合征患儿肾功能及免疫功能的影响[J].,2024,(11):2192-2196 |
| 他克莫司联合泼尼松对原发性肾病综合征患儿肾功能及免疫功能的影响 |
| The Effect of Tacrolimus Combined with Prednisone on Renal Function and Immune Function in Children with Primary Nephrotic Syndrome |
| 投稿时间：2023-12-10 修订日期：2023-12-30 |
| DOI：10.13241/j.cnki.pmb.2024.11.037 |
| 中文关键词: 原发性肾病综合征 泼尼松 他克莫司 肾功能 免疫功能 |
| 英文关键词: Primary nephrotic syndrome Prednisone Tacrolimus Renal function Immunity function |
| 基金项目:河北省2018年度医学科学研究重点课题计划（20180631） |
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| 中文摘要: |
| 摘要 目的：探讨原发性肾病综合征（PNS）患儿经他克莫司联合泼尼松治疗后肾功能及免疫功能变化情况。方法：采用随机数字表法将于2018年6月~2022年7月在河北省儿童医院接受治疗的82例PNS患儿分为A组和B组，各41例。A组给予醋酸泼尼松片，在A组患者治疗的基础上，采用他克莫司胶囊对B组患者进行治疗。两组治疗时间均为6个月。比较两组治疗前、治疗6个月后的肾功能、免疫功能、血脂指标、纤维蛋白原（FIB）、C反应蛋白（CRP）、微量白蛋白（U-mALb）及尿N-乙酰-β-D氨基葡萄糖苷酶（NAG）。结果：与治疗前比较，治疗6个月后，两组肾功能指标及血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、FIB、CRP及尿NAG、U-mALb水平均降低，且与A组比较，B组较低；两组全血CD3+、CD4+、CD4+/CD8+、NK细胞、血清高密度脂蛋白胆固醇（HDL-C）水平均升高，且与A组比较，B组较高（P<0.05）。结论：PNS患儿经他克莫司联合泼尼松治疗后炎症反应明显减轻，且患儿肾功能及免疫功能得到有效改善，血脂、FIB水平也得以调节。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes in renal and immune function in children with primary nephrotic syndrome (PNS) after treatment with tacrolimus combined with prednisone. Methods: 82 children with PNS admitted to Hebei Children's Hospital from June 2018 to July 2022 were divided into the group A and the group B by random number table method, 41 cases in each group. The group A was given prednisone acetate tablets, and on the basis of treatment for the group A patients, tacrolimus capsules were used to treat the group B patients. The treatment time for both groups were 6 months. The renal function, immune function, blood lipid indicators, fibrinogen (FIB), C-reactive protein (CRP), microalbumin (U-mALb) and urinary N-acetyl - β- D-glucosaminidase (NAG) between the two groups before and after 6 months of treatment were compared. Results: Compared with before treatment, after 6 months of treatment, the levels of renal function indicators and serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), FIB, CRP and urine NAG, U-mALb in both groups decreased, and compared with the group A, the group B was lower; The levels of whole blood CD3+, CD4+, CD4+/CD8+, NK cells and serum high-density lipoprotein cholesterol (HDL-C) in the two groups increased, and compared with the group A, the levels in the group B were higher(P<0.05). Conclusion: After treatment with tacrolimus combined with prednisone, the inflammatory response in PNS patients was significantly reduced, and their renal and immune functions were effectively improved. Levels of lood lipids and FIB were also regulated. |
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