| 崔金涛,田 霞,许建生,王娇娇,姜 萌,殷少龙.动态增强磁共振成像参数联合CEA、NLR、PLR对宫颈癌患者新辅助化疗疗效的预测价值[J].,2024,(11):2169-2172 |
| 动态增强磁共振成像参数联合CEA、NLR、PLR对宫颈癌患者新辅助化疗疗效的预测价值 |
| Predictive Value of Dynamic Contrast-Enhanced Magnetic Resonanceimaging Parameters Combined with CEA, NLR, and PLR for the Efficacy of Neoadjuvant Chemotherapy in Cervical Cancer Patients |
| 投稿时间：2023-10-26 修订日期：2023-11-22 |
| DOI：10.13241/j.cnki.pmb.2024.11.032 |
| 中文关键词: 动态增强磁共振成像 CEA NLR PLR 宫颈癌 |
| 英文关键词: Dynamic contrast-enhanced magnetic resonance imaging CEA NLR PLR Cervical cancer |
| 基金项目:河北省医学科学研究课题计划项目（20221898） |
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| 中文摘要: |
| 摘要 目的：研究动态增强磁共振成像（DCE-MRI）参数联合癌胚抗原（CEA）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）对宫颈癌患者新辅助化疗疗效的预测价值。方法：选取110例2020年5月到2023年5月在张家口市第一医院接受宫颈癌根治术治疗的宫颈癌患者，根据治疗效果分为有效组和无效组。对比有效组及无效组两组的一般资料、DCE-MRI参数、血清CEA及外周血NLR、PLR。受试者工作特征（ROC）曲线分析DCE-MRI参数联合血清CEA、外周血NLR、PLR对新辅助化疗疗效的预测价值。结果：选取的110例患者中，有效组78例，无效组32例，有效组对比增强率（CER）及转运常数（Ktrans）水平较无效组更低（P＜0.05），两组的其他DCE-MRI参数速率常数（Kep）、对比剂浓度时间的曲线下面积（IAUGC）、血管外细胞间隙体积百分数（Ve）及最大斜率（Maxslope）比较，差异不显著（P＞0.05）。有效组的血清CEA及外周血NLR、PLR较无效组明显更低（P＜0.05）。CER、Ktrans联合血清CEA及外周血NLR、PLR对新辅助化疗疗效的预测价值最佳，其AUC为0.896，敏感度为0.915，特异度为0.802，均高于各项指标单独检测。结论：DCE-MRI参数联合CEA、NLR、PLR有助于提升对宫颈癌患者新辅助化疗疗效的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) parameters combined with carcino-embryonic antigen(CEA), neutrophils and lymphocytes ratio(NLR), platelet-to-lymphocyte ratios(PLR) for the efficacy of neoadjuvant chemotherapy in cervical cancer patients. Methods: 110 cases of cervical cancer patients who received radical hysterectomy treatment in Zhangjiakou First Hospital from May 2020 to May 2023 were selected and divided into effective group and ineffective group based on the treatment effect. The general data, DCE-MRI parameters, serum CEA and peripheral blood NLR and PLR of the effective group and ineffective group were compared. The predictive value of DCE-MRI parameters combined with serum CEA, peripheral blood NLR and PLR on the efficacy of neoadjuvant chemotherapy was analyzed by Receiver Operating Characteristic (ROC) curve. Results: Among the 110 patients selected, 78 were in the effective group, and 32 were in the ineffective group. The contrast enhancement rate (CER) and transport constant (Ktrans) levels in the effective group were lower than those in the ineffective group (P<0.05), but there were no significant differences in other DCE-MRI parameters rate constant (Kep), initial area under the gadolinium curve (IAUGC), percentage of extracellular space volume (Ve) and maximum slope (Maxslope) between the two groups (P>0.05). The serum CEA and peripheral blood NLR and PLR in the effective group were significantly lower than those in the ineffective group (P<0.05). CER, Ktrans combined with serum CEA and peripheral blood NLR and PLR had the best predictive value for the efficacy of neoadjuvant chemotherapy, with AUC was 0.896, and sensitivity was 0.915, specificity was 0.802, which were higher than each single detection. Conclusion: DCE-MRI parameters combined with CEA, NLR and PLR can help to improving predictive value of the efficacy of neoadjuvant chemotherapy in cervical cancer patients. |
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