| 张珊珊,孟 侠,王静依,彭 燕,陈国艳,杨智玲.血清FM、TAT、MIP-1α与产后静脉血栓栓塞症的关系及其预测价值研究[J].,2024,(11):2164-2168 |
| 血清FM、TAT、MIP-1α与产后静脉血栓栓塞症的关系及其预测价值研究 |
| Study on the Relationship between Serum FM, TAT, MIP-1α and Postpartum Venous Thromboembolism and its Predictive Value |
| 投稿时间：2023-10-06 修订日期：2023-10-27 |
| DOI：10.13241/j.cnki.pmb.2024.11.031 |
| 中文关键词: FM TAT MIP-1α 产后 静脉血栓栓塞症 |
| 英文关键词: FM TAT MIP-1α Postpartum Venous thromboembolism |
| 基金项目:成都市医学科研课题（2023620）；四川省卫生和计划生育委员会研究项目(17PJ250) |
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| 中文摘要: |
| 摘要 目的：探讨血清纤维蛋白单体（FM）、凝血酶-抗凝血酶复合物（TAT）、巨噬细胞炎性蛋白-1α（MIP-1α）与产后静脉血栓栓塞症（VTE）的关系及其预测价值研究。方法：选取2021年12月-2023年12月在成都医学院第二附属医院分娩后有VTE的产妇纳入VTE组（n＝45），根据1:4配对方法选择我院同期分娩后无VTE的产妇纳入非VTE组（n＝180）。采用酶联免疫吸附法（ELISA）检测血清FM、TAT、MIP-1α、D-二聚体（D-D）水平。多因素Logistic回归分析产后发生VTE的影响因素，并绘制受试者工作特征（ROC）曲线分析血清FM、TAT、MIP-1α、D-D水平对产后VTE的预测价值。结果：与非VTE组比较，VTE组血清FM、TAT、MIP-1α、D-D水平升高（P＜0.05）。多因素Logistic回归分析显示，年龄增加、剖宫产和FM、TAT、MIP-1α、D-D升高为影响产后VTE的独立危险因素（P＜0.05）。ROC曲线分析显示，血清FM、TAT、MIP-1α、D-D水平联合预测产后VTE的曲线下面积为0.911，大于血清FM、TAT、MIP-1α、D-D水平单独预测的0.748、0.755、0.722、0.592。结论：血清FM、TAT、MIP-1α水平升高是产后VTE的独立危险因素，血清FM、TAT、MIP-1α联合D-D对产后VTE的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum fibrin monomer (FM), thrombin-antithrombin complex (TAT), macrophage inflammatory protein-1α (MIP-1α) and postpartum venous thromboembolism (VTE) and its predictive value. Methods: Pregnant women with VTE after delivery in The Second Affiliated Hospital of Chengdu Medical College from December 2021 to December 2023 were included in VTE group (n=45), pregnant women without VTE after delivery in our hospital during the same period were included in non-VTE group (n=180) according to the 1:4 pairing method. Serum FM, TAT, MIP-1α and D-dimer (D-D) levels were detected by enzyme-linked immunosorbent assay (ELISA). The influencing factors of postpartum VTE were analyzed by multivariate Logistic regression analysis, and the predictive value of serum FM, TAT, MIP-1α and D-D levels for postpartum VTE were analyzed by receiver operating characteristic (ROC) curve. Results: Compared with non-VTE group, the serum levels of FM, TAT, MIP-1α and D-D in VTE group were increased (P<0.05). Multivariate Logistic regression analysis showed that, increased age, uterine-incision delivery and increased FM, TAT, MIP-1α, and D-D were independent risk factors for postpartum VTE (P<0.05). ROC curve analysis showed that, the area under the curve of combined prediction of serum FM, TAT, MIP-1α and D-D levels for postpartum VTE was 0.911, which was greater than 0.748, 0.755, 0.722 and 0.592 predicted by serum FM, TAT, MIP-1α and D-D levels alone. Conclusion: The increase of serum FM, TAT and MIP-1α levels are independent risk factors for postpartum VTE, serum FM, TAT, MIP-1α combine with D-D has a high predictive value for postpartum VTE. |
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