| 马倩倩,祖蓓蓓,殷松楼,刘 琳,饶咏梅.系统性红斑狼疮患者血清NGAL、HMGB1、Gal-3与疾病活动度和颈动脉粥样硬化的关系分析[J].,2024,(9):1731-1735 |
| 系统性红斑狼疮患者血清NGAL、HMGB1、Gal-3与疾病活动度和颈动脉粥样硬化的关系分析 |
| Analysis of the Relationship between Serum NGAL, HMGB1, Gal-3 and Disease Activity and Carotid Atherosclerosis in Systemic Lupus Erythematosus Patients |
| 投稿时间：2023-11-10 修订日期：2023-11-30 |
| DOI：10.13241/j.cnki.pmb.2024.09.026 |
| 中文关键词: 系统性红斑狼疮 NGAL HMGB1 Gal-3 疾病活动度 颈动脉粥样硬化 |
| 英文关键词: Systemic lupus erythematosus NGAL HMGB1 Gal-3 Disease activity Carotid atherosclerosis |
| 基金项目:江苏省卫生健康委科研课题（F201840） |
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| 中文摘要: |
| 摘要 目的：分析系统性红斑狼疮（SLE）患者血清中性粒细胞明胶酶相关载脂蛋白（NGAL）、高迁移率族蛋白B1（HMGB1）、半乳糖凝集素-3（Gal-3）与疾病活动度和颈动脉粥样硬化（CAS）的关系。方法：选取2020年1月到2023年3月在徐州市中心医院收治的160例SLE患者。采用酶联免疫吸附法检测血清NGAL、HMGB1 、Gal-3水平。根据SLE疾病活动度指数（SLEDAI）评分将患者分为无活动组（n=48）、重度活动组（n=32）中度活动组（n=39）、轻度活动组（n=41）。同时根据颈动脉彩色多普勒超声检查结果将患者分为CAS组（n=56）和无CAS组（n=104）。对比各组血清NGAL、HMGB1、Gal-3水平的差异。SLE发生CAS的影响因素采用多因素logistic回归分析。结果：无活动组、轻度活动组、中度活动组、重度活动组的血清NGAL、HMGB1 、Gal-3的水平依次升高，整体对比差异有统计学意义（P<0.05）。CAS组的血清NGAL、HMGB1、Gal-3的水平高于无CAS组（P<0.05）。多因素logistic回归分析结果显示，高NGAL、高HMGB1 、高Gal-3高、高年龄、SLE病程长是SLE患者发生CAS的危险因素，而规范应用羟氯喹药物治疗是保护因素（P<0.05）。结论：SLE患者血清NGAL、HMGB1 、Gal-3水平升高，且随着疾病严重程度的增加而增加。同时，高NGAL、HMGB1 、Gal-3、年龄以及SLE病程长是SLE患者发生CAS的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum neutrophil gelatinase associated lipocalin (NGAL), high mobility group protein B1 (HMGB1), galectin-3 (Gal-3) and disease activity and carotid atherosclerosis (CAS) in systemic lupus erythematosus (SLE) patients. Methods: 160 SLE patients who were admitted to Xuzhou Central Hospital from January 2020 to March 2023 were selected as study subjects. The levels of serum NGAL, HMGB1 and Gal-3 were detected by enzyme-linked immunosorbent assay. According to SLE disease activity index (SLEDAI) score, the patients were divided into inactive group (n=48), severe activity group (n=32) , moderate activity group (n=39) and mild activity group (n=41). And patients were divided into CAS group (n=56) and non-CAS group (n=104) according to the results of carotid color Doppler ultrasonography. The differences of serum NGAL, HMGB1 and Gal-3 levels in each group were compared. Multiple Logistic regression analysis was used to investigate the influencing factors occurrence of CAS in SLE. Results: The levels of serum NGAL, HMGB1 and Gal-3 in inactive group, mild activity group, moderate activity group and severe activity group increased in turn, and overall comparison difference was statistically significant(P<0.05). The levels of serum NGAL, HMGB1 and Gal-3 in CAS group were higher than those in non-CAS group(P<0.05). Multivariate logistic regression analysis showed that, high NGAL, high HMGB1, high Gal-3, high age and long course of SLE were risk factors for CAS in SLE patients, while standardized application of hydroxychloroquine drug therapy was protective factor(P<0.05). Conclusion: The levels of serum NGAL, HMGB1 and Gal-3 in SLE patients increase with the severity of the disease. At the same time, high NGAL, HMGB1, Gal-3, age and long course of SLE are risk factors for CAS in SLE patients. |
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