| 季 静,郭红玉,陆 葳,陈 聪,周 云.补肾调周法联合维生素E治疗功能性痛经的临床疗效及对子宫血流动力学、炎症因子的影响[J].,2024,(8):1511-1515 |
| 补肾调周法联合维生素E治疗功能性痛经的临床疗效及对子宫血流动力学、炎症因子的影响 |
| Clinical Efficacy of Invigorating Kidney and Regulating Zhou Method Combined with Vitamin E in the Treatment of Functional Dysmenorrhea and Its Influence on Uterine Hemodynamics and Inflammatory Factors |
| 投稿时间：2023-10-08 修订日期：2023-10-29 |
| DOI：10.13241/j.cnki.pmb.2024.08.021 |
| 中文关键词: 功能性痛经 补肾调周法 维生素E 子宫血流动力学 |
| 英文关键词: Functional dysmenorrhea Tonifying kidney and regulating Zhou Vitamin E Uterine hemodynamics |
| 基金项目:江苏省妇幼保健科研项目（F202206） |
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| 中文摘要: |
| 摘要 目的：分析夏桂成教授补肾调周法联合维生素E治疗功能性痛经的临床疗效及对子宫血流动力学、炎症因子的影响。方法：选择我院自2021年1月至2022年12月接诊的106例功能性痛经患者作为研究对象，随机分为对照组和观察组，各53例。对照组予以维生素E治疗，观察组予以补肾调周法联合维生素E治疗。在治疗前及治疗3个月经周期后，检测子宫动脉收缩期血流速度（Vs）、子宫动脉舒张期血流速度（Vd）、平均速度（Vm）、阻力指数（RI）及血清超敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）、前列腺素（PG）F2α、PGE2水平，比较两组不同时间点的痛经VAS评分、治疗总有效率。结果：观察组治疗后Vs、Vd、Vm均大于对照组，RI小于对照组（P＜0.05）；观察组治疗后血清hs-CRP、IL-6水平均低于对照组（P＜0.05）；观察组治疗后血清PGF2α水平低于对照组，PGE2水平高于对照组（P＜0.05）；观察组治疗结束时及治疗结束后第3个月经周期的痛经VAS评分均低于对照组（P＜0.05）；观察组治疗总有效率为94.34%，高于对照组的71.70%（P＜0.05）。结论：补肾调周法联合维生素E治疗功能性痛经的临床疗效显著，能够明显改善子宫血流动力学和降低炎症因子水平，值得进一步研究应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical efficacy of tonifying kidney and tiao Zhou method combined with vitamin E in the treatment of functional dysmenorrhea and its influence on uterine hemodynamics and inflammatory factors. Methods: 106 patients with functional dysmenorrhea admitted to our hospital from January 2021 to December 2022 were selected as the study objects and randomly divided into control group and observation group, with 53 cases in each group. The control group was treated with vitamin E, and the observation group was treated with tonifying kidney and tiaozhou combined with vitamin E. Systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd), mean blood velocity (Vm), resistance index (RI) and serum levels of hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), prostaglanin (PG)F2α and PGE2 were measured before and after 3 menstrual cycles. The dysmenorrhea VAS score and the total effective rate of treatment were compared between the two groups at different time points. Results: After treatment, Vs, Vd and Vm in observation group were higher than control group, RI was lower than control group (P<0.05). After treatment, serum hs-CRP and IL-6 levels in observation group were lower than those in control group (P<0.05). After treatment, the level of serum PGF2α in observation group was lower than that in control group, and the level of PGE2 was higher than that in control group (P<0.05). The VAS scores of the observation group at the end of treatment and the third menstrual cycle after treatment were lower than those of the control group (P<0.05). The total effective rate of the observation group was 94.34%, higher than that of the control group (71.70%) (P<0.05). Conclusion: The treatment of functional dysmenorrhea by invigorating kidney and regulating Zhou combined with vitamin E has significant clinical effect,which can improve uterine hemodynamics and reduce the level of inflammatory factors, and is worthy of further study and application. |
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