| 张 煜,吕 兰,王 伟,孙耀华,张力为.肺腺癌组织DCLK1、GPD2、hMTERF3 表达与临床病理特征及预后的关系[J].,2024,(8):1490-1494 |
| 肺腺癌组织DCLK1、GPD2、hMTERF3 表达与临床病理特征及预后的关系 |
| Relationship between the Expression of DCLK1, GPD2, hMTERF3 and Clinicopathological Features and Prognosis in Lung Adenocarcinoma Tissue |
| 投稿时间：2023-10-19 修订日期：2023-11-23 |
| DOI：10.13241/j.cnki.pmb.2024.08.017 |
| 中文关键词: 肺腺癌 DCLK1 GPD2 hMTERF3 临床病理特征 预后 |
| 英文关键词: Lung adenocarcinoma DCLK1 GPD2 hMTERF3 Clinicopathological features Prognosis |
| 基金项目:山东省医药卫生科技发展计划项目（202004020834） |
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| 中文摘要: |
| 摘要 目的：探讨肺腺癌组织双皮质素样激酶1（DCLK1）、甘油-3-磷酸脱氢酶2（GPD2）、人线粒体转录终止因子3（hMTERF3）表达与临床病理特征及预后的关系。方法：选择2017年6月至2020年6月新疆医科大学第一附属医院胸外科收治的125例肺腺癌患者，取手术切除的癌组织以及癌旁组织（距离癌组织5 cm以上）。采用免疫组化法检测癌组织以及癌旁组织的DCLK1、GPD2、hMTERF3表达。分析DCLK1、GPD2、hMTERF3表达与肺腺癌患者临床病理特征的关系。采用Kaplan-Meier法绘制生存曲线分析不同DCLK1、GPD2、hMTERF3表达肺腺癌患者3年总生存率（OS）、无进展生存率（PFS）。结果：癌组织DCLK1、GPD2、hMTERF3阳性表达率均高于癌旁组织（P＜0.05）。低分化，TNM分期ⅢA期，淋巴结转移肺腺癌组织DCLK1、GPD2、hMTERF3 阳性表达率高于中高分化、TNM分期Ⅰ、Ⅱ期、无淋巴结转移肺腺癌组织（P＜0.05）。DCLK1、GPD2、hMTERF3阳性表达肺腺癌患者3年OS率、3年PFS率低于DCLK1、GPD2、hMTERF3阴性表达肺腺癌患者（P＜0.05）。结论：肺腺癌组织中DCLK1、GPD2、hMTERF3阳性表达率升高，且与肺腺癌恶性病理特征和短期不良预后有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of dicortin-like kinase 1 (DCLK1), glycerol-3- phosphate dehydrogenase 2 (GPD2), human mitochondrial transcription termination factor 3 (hMTERF3) and clinicopathological features and prognosis in lung adenocarcinoma tissue. Methods: 125 lung adenocarcinoma patients who were admitted to the Department of Thoracic Surgery of The First Affiliated Hospital of Xinjiang Medical Universityy from June 2017 to June 2020 were selected, the cancer tissues and adjacent tissues (more than 5cm from the cancer tissues) were taken. The expression of DCLK1, GPD2 and hMTERF3 in cancer tissues and adjacent tissues was detected by immunohistochemistry. The relationship between the expression of DCLK1, GPD2, hMTERF3 and the clinicopathological features of lung adenocarcinoma patients were analyzed. The 3-year overall survival (OS) and progression-free survival (PFS) of lung adenocarcinoma patients with different DCLK1, GPD2 and hMTERF3 expression were analyzed by Kaplan-Meier method. Results: The positive expression rates of DCLK1, GPD2 and hMTERF3 in cancer tissues were higher than those in adjacent tissues (P<0.05). The positive expression rates of DCLK1, GPD2 and hMTERF3 in lung adenocarcinoma tissues with low differentiation, TNM stage IIIA and lymph node metastasis were higher than those in lung adenocarcinoma tissues with middle and high differentiation, TNM stage I, II and no lymph node metastasis (P<0.05). The 3-year OS rate and 3-year PFS rate of lung adenocarcinoma patients with positive expression of DCLK1, GPD2 and hMTERF3 were lower than those of lung adenocarcinoma patients with negative expression of DCLK1, GPD2 and hMTERF3 (P<0.05). Conclusion: The positive expression rates of DCLK1, GPD2 and hMTERF3 in lung adenocarcinoma tissues are increase, which are relate to the malignant pathological characteristics and short-term poor prognosis of lung adenocarcinoma. |
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