| 胡伯媛,许厚本,杨 耀,徐 星,肖 芳,言 娜.实时超声弹性成像参数、血清CA153、IGF1及HE4水平与早期宫颈癌临床病理特征的关系及其预测价值分析[J].,2024,(7):1335-1339 |
| 实时超声弹性成像参数、血清CA153、IGF1及HE4水平与早期宫颈癌临床病理特征的关系及其预测价值分析 |
| Relationship between Real-Time Ultrasound Elastography Parameters, Serum CA153, IGF1 and HE4 Levels and Clinicopathological Features of Early Cervical Cancer and Analysis of Their Predictive Value |
| 投稿时间：2023-10-31 修订日期：2023-11-25 |
| DOI：10.13241/j.cnki.pmb.2024.07.026 |
| 中文关键词: 实时超声弹性成像 CA153 IGF1 HE4 早期宫颈癌 诊断价值 |
| 英文关键词: Real-time ultrasound elastography CA153 IGF1 HE4 Early cervical cancer Diagnostic value |
| 基金项目:湖南省医药卫生科研计划课题项目（B2015-77） |
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| 中文摘要: |
| 摘要 目的：探讨实时超声弹性成像参数、血清糖类抗原153（CA153）、胰岛素生长因子1（IGF1）及人附睾分泌蛋白4（HE4）水平与早期宫颈癌临床病理特征的关系及其预测价值。方法：选取2022年1月~2023年6月本院收治的85例早期宫颈癌患者为宫颈癌组，另取同期收治的85例宫颈癌前病变患者为宫颈癌前病变组。两组均进行实时超声弹性成像检查，并测定血清CA153、IGF1及HE4水平。探讨实时超声成像、血清CA153、IGF1及HE4与宫颈癌患者临床病理特征的关系。采用受试者工作特征曲线（ROC）分析实时超声弹性成像参数、血清CA153、IGF1及HE4对早期宫颈癌患者的诊断价值。结果：相较于宫颈癌前病变组，宫颈癌组弹性应变比值和弹性图像压放指数均明显升高（P<0.05），血清CA153、IGF1及HE4水平均明显升高（P<0.05）；FIGO分期Ⅱ期、低分化程度患者实时超声成像参数、血清CA153、IGF1及HE4水平均明显高于FIGO分期Ⅰ期、中高分化程度患者（P<0.05）；ROC曲线显示，弹性应变比值、弹性图像压放指数、CA153、IGF1、HE4诊断早期宫颈癌的曲线下面积（AUC）分别为0.811、0.807、0.760、0.649、0.764，联合诊断的AUC最大，为0.944。结论：实时超声弹性成像参数、血清CA153、IGF1及HE4与早期宫颈癌的分期和分化程度有关，且对诊断早期宫颈癌均具有一定的临床价值，以联合诊断的价值更高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between real-time ultrasound elastography parameters, serum carbohydrate antigen 153 (CA153), insulin growth factor 1 (IGF1), and human epididymal secreted protein 4 (HE4) levels with clinicopathological features of early cervical cancer and their predictive value. Methods: 85 patients with early cervical cancer admitted to our hospital from January 2022 to June 2023 were selected as the cervical cancer group,and another 85 patients with cervical precancerous lesions admitted during the same period were selected as the cervical precancerous lesion group. Both groups underwent real-time ultrasound elastography and serum levels of CA153, IGF1, and HE4 were measured. Explored the relationship between real-time ultrasound imaging, serum CA153, IGF1, and HE4 levels and clinical pathological characteristics of cervical cancer patients. The diagnostic value of real-time ultrasound elastography parameters, serum CA153, IGF1, and HE4 in early cervical cancer patients was analyzed using receiver operating characteristic(ROC). Results: Compared with the cervical precancerous lesion group, the elastic strain ratio and elastic image compression index of the cervical cancer group were significantly increased (P<0.05), and the serum levels of CA153, IGF1 and HE4 were significantly increased(P<0.05). The real-time ultrasound imaging parameters, serum CA153, IGF1 and HE4 levels in patients with FIGO II stage and low differentiation were significantly higher than those in patients with FIGO I stage and medium to high differentiation(P<0.05). ROC curve showed that the area under the curve (AUC) of elastic strain ratio, elastic image compression index, CA153, IGF1 and HE4 in the diagnosis of early cervical cancer was 0.811, 0.807, 0.760, 0.649 and 0.764, respectively, and the AUC of combined diagnosis was the largest, 0.944. Conclusion: Real-time ultrasound elastography parameters, serum CA153, IGF1 and HE4 are related to the stage and differentiation of early cervical cancer, and have certain clinical value in the diagnosis of early cervical cancer, and the value of combined diagnosis is higher. |
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