| Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25 (OH) D], monocyte chemoattractant protein 1 (MCP-1), pentraxin 3 (PTX3) levels in patients with chronic obstructive pulmonary disease (COPD) and osteoporosis. Methods: 182 COPD patients (COPD group) admitted to our hospital from December 2021 to November 2023 and 95 healthy individuals (control group) who underwent physical examination in our hospital during the same period were selected. Serum levels of 25 (OH) D, MCP-1 and PTX3 were compared between the control group and the COPD group. COPD patients were divided into osteoporosis group and non- osteoporosis group based on the occurrence of osteoporosis, serum levels of 25 (OH) D, MCP-1 and PTX3 were compared between the osteoporosis group and non-osteoporosis group. General information of COPD patients was collected, and the influencing factors of osteoporosis in patients with COPD were analyzed using univariate and multivariate Logistic regression analysis. The diagnostic value of serum levels of 25 (OH) D, MCP-1 and PTX3 for COPD complicated with osteoporosis was analyzed using the receiver operating characteristic (ROC) curve. Results: The serum level of 25 (OH) D in COPD group was lower than that in the control group, and the serum levels of MCP-1 and PTX3 were higher than those in the control group (P<0.05). Bone density examination showed that, 89 cases of osteoporosis occurred in the COPD group (osteoporosis group), accounting for 48.90%. The serum level of 25 (OH) D in the osteoporosis group was lower than that in the non-osteoporosis group, and the serum levels of MCP-1 and PTX3 were higher than those in the non-osteoporosis group (P<0.05). Univariate analysis showed that the occurrence of osteoporosis in COPD patients was not related to gender, drinking history, number of COPD exacerbations, disease course, Global Initiative for Chronic Obstructive Lung Disease (GOLD) grading, coronary heart disease, hypertension, diabetes (P>0.05), but was related to age, history of glucocorticoid use, body mass index, smoking history, etc. (P<0.05). Multivariate Logistic regression analysis showed that advanced age, history of glucocorticoid use, low body mass index, smoking history, decreased serum level of 25(OH)D, and increased serum levels of MCP-1 and PTX3 are risk factors for osteoporosis in patients with COPD (P<0.05). The ROC curve showed that the area under the curve (AUC) for diagnosing COPD complicated with osteoporosis for single indicators of serum 25(OH)D, MCP-1, and PTX3 were 0.765, 0.762, and 0.758, respectively, and the AUC for combined detection of the three indicators was 0.856, which was better than single indicator detection. Conclusion: Decreased serum level of 25(OH)D and increased serum levels of MCP-1 and PTX3 jointly promote the progression of osteoporosis in patients with COPD, and combined detection of the three indicators may have a higher diagnostic value for COPD complicated with osteoporosis. |
