| Objective: To observe the effect of banxia xiexin decoction on mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway in peripheral blood of patients with Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG). Methods: According to the random number table method, 96 Hp positive CAG patients admitted to The First Hospital of Shanxi Medical University from March 2021 to May 2023 were divided into control group (conventional quadruple therapy, 48 cases) and observation group (banxia xiexin decoction combined with conventional quadruple therapy, 48 cases). The efficacy, Hp eradication rate, traditional chinese medicine syndrome points, pepsinogen (PG) and MAPK/ERK signaling pathway related indicators were compared between two groups. Results: The total clinical effective rate (93.75%) and Hp eradication rate (91.67%) in observation group were higher than those in control group (70.83%) (83.33%) (P<0.05). Compared with control group after treatment, the main symptoms, secondary symptoms, total scores, PGII, MEK1 messenger ribonucleic acid (mRNA), MEK2 mRNA, ERK1 mRNA, and ERK2 mRNA in observation group were lower, and PGI was higher (P<0.05). Conclusion: Banxia xiexin decoction in the treatment of Hp positive CAG patients, which can improve the clinical treatment effect, improve the clinical symptoms and PG level, and regulate the MAPK/ERK signaling pathway in peripheral blood. |
