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| 米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清GLP-1和PYY水平的影响 |
| Effects of Aspergillus Oryzae Pancreatin Tablets on Intestinal Flora, Gastrointestinal Function and Serum GLP-1 and PYY Levels in Patients With Cirrhosis-Related Dyspepsia |
| 投稿时间：2024-07-02 修订日期：2024-07-02 |
| DOI： |
| 中文关键词: 米曲菌胰酶片 肝硬化 消化不良 肠道菌群 胃肠功能 胰高糖素样肽-1 酪酪肽 |
| 英文关键词: Aspergillus oryzae pancreatin tablets Cirrhosis Dyspepsia Intestinal flora Gastrointestinal function Glucagon-like peptide-1 Casein peptide |
| 基金项目:山西省医学重点科研项目（2020XM23） |
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| 中文摘要: |
| 目的：探讨米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清胰高糖素样肽-1（GLP-1）和酪酪肽（PYY）水平的影响。方法：按照随机数字表法，将2021年3月~2023年12月期间在我院就诊的129例肝硬化相关消化不良患者分为对照组（肝硬化常规治疗，n=64）和实验组（在对照组的基础上接受米曲菌胰酶片治疗，n=65）。对比两组消化不良症状积分、肠道菌群指标、胃肠功能指标、血清GLP-1和PYY水平、生活质量变化情况。结果：实验组治疗第2周后、治疗第4周后消化不良症状积分低于对照组（P＜0.05）。实验组治疗第4周后肠球菌、肠杆菌数量低于对照组，双歧杆菌、乳酸杆菌数量高于对照组（P＜0.05）。实验组治疗第4周后胃排空率、胃运动指数、胃收缩频率、肠蠕动频率高于对照组（P＜0.05）。实验组治疗第4周后GLP-1和PYY水平低于对照组（P＜0.05）。实验组治疗第4周后NDI评分低于对照组（P＜0.05）。结论：米曲菌胰酶片通过促进肠道菌群平衡、改善胃肠功能、调节血清GLP-1和PYY水平，可减轻肝硬化患者的消化不良症状，改善患者的生活质量。 |
| 英文摘要: |
| Objective: To investigate the effects of aspergillus oryzae pancreatin tablets on intestinal flora, gastrointestinal function and serum glucagon-like peptide-1 (GLP-1) and casein peptide (PYY) levels in patients with cirrhosis-related dyspepsia. Methods: According to the random number table method, 129 patients with liver cirrhosis-related dyspepsia who were treated in our hospital from March 2021 to December 2023 were divided into control group (routine treatment of liver cirrhosis, n=64 ) and experimental group (treated with aspergillus oryzae trypsin tablets on the basis of control group, n=65). The changes of dyspepsia symptom score, intestinal flora index, gastrointestinal function index, serum GLP-1 and PYY levels and quality of life were compared between two groups. Results: The scores of dyspepsia symptoms in experimental group were lower than those in control group 2 weeks after treatment and 4 weeks after treatment (P<0.05). The number of enterococcus and enterobacter in experimental group was lower than that in control group 4 weeks after treatment, and the number of bifidobacteria and lactobacilli was higher than that in control group (P<0.05). The gastric emptying rate, gastric motility index, gastric contraction frequency and intestinal peristalsis frequency in experimental group were higher than those in control group 4 weeks after treatment (P<0.05). The levels of GLP-1 and PYY in experimental group were lower than those in control group 4 weeks after treatment (P<0.05). The NDI score in experimental group was lower than that in control group 4 weeks after treatment (P<0.05). Conclusion: Aspergillus oryzae pancreatin tablets by promoting the balance of intestinal flora, improving gastrointestinal function and regulating serum GLP-1 and PYY levels, which can alleviate the dyspepsia symptoms of patients with cirrhosis and improve the quality of life of patients. |
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