| Objective: To investigate the effects of letrozole combined with yishen ovulation-promoting decoction on ovarian function, endocrine level, serum growth hormone releasing peptide (Ghrelin), anti-Mullerian hormone (AMH) and nuclear transcription factor-κB (NF-κB) in patients with polycystic ovary syndrome (PCOS) infertility. Methods: Random number table method was used, patients with PCOS infertility (132 cases) who were treated in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from February 2020 to March 2023 were divided into control group (66 cases, letrozole treatment) and experimental group (66 cases, letrozole, yishen ovulation-promoting decoction combined treatment). The traditional chinese medicine syndrome scores, endocrine indexes, ovarian function indexes, serum Ghrelin, AMH, NF-κB levels, ovulation and pregnancy were compared between two groups. Results: Compared with control group after treatment, the traditional chinese medicine syndrome score, basic luteinizing hormone (LH), pulsatility index, resistance index, NF-κB, AMH in experimental group were lower, and mid-luteal estradiol (E2), mid-luteal progesterone (P), endometrial thickness, Ghrelin were higher (P<0.05). Six months after follow-up, the ovulation rate and pregnancy rate in experimental group were higher than those in control group (P<0.05). Conclusion: Letrozole combine with yishen ovulation-promoting decoction in the treatment of PCOS infertility patients, which can effectively improve the endocrine level, ovarian function, serum Ghrelin, AMH and NF-κB levels, and improve the pregnancy rate and ovulation rate. |
