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| LncRNA SOCS2-AS1、miR-454-3p在人胃癌组织中的表达及临床意义 |
| Expression and Clinical Significance of LncRNA SOCS2-AS1 and miR-454-3p in Human Gastric Cancer Tissues |
| 投稿时间：2024-07-02 修订日期：2024-07-02 |
| DOI： |
| 中文关键词: 胃癌 LncRNA SOCS2-AS1 miR-454-3p 病理特征 预后 |
| 英文关键词: Gastric cancer LncRNA SOCS2-AS1 miR-454-3p Pathological features Prognosis |
| 基金项目:江苏省科技厅社会发展-临床前沿技术项目（BE2018669） |
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| 中文摘要: |
| 目的 探讨长链非编码核糖核酸（LncRNA）细胞因子信号转导抑制因子2-反义转录本1（SOCS2-AS1）、微小核糖核酸（miRNA）-454-3p在人胃癌组织中的表达及临床意义。方法 选取120例行胃癌根治术患者的胃癌组织和癌旁组织。检测并对比胃癌组织和癌旁组织中LncRNA SOCS2-AS1、miR-454-3p表达，采用Pearson法分析胃癌组织中LncRNA SOCS2-AS1与miR-454-3p的表达相关性。随访3年，根据胃癌组织中LncRNA SOCS2-AS1、miR-454-3p表达均值将胃癌患者分为LncRNA SOCS2-AS1、miR-454-3p高/低表达组，使用Kaplan-Meier法绘制生存曲线，采用多因素COX回归分析胃癌患者预后不良的影响因素。结果 胃癌组织中LncRNA SOCS2-AS1、miR-454-3p表达均低于癌旁组织（P＜0.05）。LncRNA SOCS2-AS1、miR-454-3p表达与分化程度、浸润深度、淋巴结转移、TNM分期有关（P＜0.05）。胃癌组织中LncRNA SOCS2-AS1与miR-454-3p表达呈正相关（P＜0.05）。LncRNA SOCS2-AS1低表达组3年总生存率（OS）低于LncRNA SOCS2-AS1高表达组，miR-454-3p低表达组3年OS低于miR-454-3p高表达组（P＜0.05）。发生淋巴结转移、TNM分期Ⅲ期是胃癌患者预后不良的危险因素（P＜0.05），miR-454-3p、LncRNA SOCS2-AS1高表达是胃癌患者预后不良的保护因素（P＜0.05）。结论 胃癌组织中LncRNA SOCS2-AS1、miR-454-3p呈异常低表达，二者与胃癌患者病理特征及预后不良密切相关。 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of long non-coding ribonucleic acids (LncRNA) cytokine signal transduction inhibitor 2-antisense transcript 1 (SOCS2-AS1) and micribonucleic acid (miRNA)-454-3p in human gastric cancer tissues. Methods The gastric cancer tissues and adjacent tissues of 120 patients undergoing radical gastrectomy were selected. The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues and adjacent tissues was detected and compared, the correlation between LncRNA SOCS2-AS1 and miR-454-3p expression in gastric cancer tissues was analyzed by Pearson method. After 3 years of follow-up, gastric cancer patients were divided into high/low expression groups of LncRNA SOCS2-AS1 and miR-454-3p according to the mean expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues, the survival curve was drawn by Kaplan-Meier method, and the influencing factors of poor prognosis in gastric cancer patients were analyzed by multivariate COX regression. Results The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues was lower than that in adjacent tissues (P<0.05). The expression of LncRNA SOCS2-AS1 and miR-454-3p was related to the degree of differentiation, depth of invasion, lymph node metastasis and TNM stage (P<0.05). There was a positive correlation between the expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues (P<0.05). The 3-year overall survival (OS) in LncRNA SOCS2-AS1 low expression group was lower than that in LncRNA SOCS2-AS1 high expression group, and the 3-year OS in miR-454-3p low expression group was lower than that in miR-454-3p high expression group (P<0.05). Lymph node metastasis and TNM stage III were risk factors for poor prognosis in gastric cancer patients (P<0.05). High expression of miR-454-3p and LncRNA SOCS2-AS1 was a protective factor for poor prognosis in gastric cancer patients (P<0.05). Conclusion The abnormal low expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues is closely related to the pathological characteristics and poor prognosis of gastric cancer patients. |
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