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| 膀胱尿路上皮癌组织TRPM7、TRPM8表达与临床病理特征和预后的关系分析 |
| Analysis of the Relationship Between the Expression of TRPM7 and TRPM8 in Bladder Urothelial Carcinoma Tissue and Clinicopathological Features and Prognosis |
| 投稿时间：2024-07-02 修订日期：2024-07-02 |
| DOI： |
| 中文关键词: 膀胱尿路上皮癌 TRPM7 TRPM8 临床病理特征 预后 影响因素 |
| 英文关键词: Bladder urothelial carcinoma TRPM7 TRPM8 Clinicopathological features Prognosis Influencing factors |
| 基金项目:江苏省卫生健康委科研项目（H2023095） |
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| 中文摘要: |
| 目的：探究膀胱尿路上皮癌（BUC）组织瞬时受体电位阳离子通道亚家族M成员7（TRPM7）、瞬时受体电位阳离子通道亚家族M成员8（TRPM8）表达与临床病理特征和预后的关系。方法：选取2016年1月~2020年12月我院收治的127例BUC患者为研究对象，术中留取癌组织及癌旁组织。比较癌组织及癌旁组织中TRPM7、TRPM8表达情况，分析癌组织中TRPM7、TRPM8表达与临床病理特征的关系。所有BUC患者均随访3年，采用Kaplan-Meier曲线分析TRPM7、TRPM8阳性表达与阴性表达患者的生存差异，多因素Cox回归模型分析BUC患者死亡的影响因素。结果：癌组织TRPM7、TRPM8阳性表达率显著高于癌旁组织（P<0.05）。TRPM7、TRPM8阳性表达患者病理分期T2~T4期、淋巴结转移占比显著高于TRPM7、TRPM8阴性表达患者（P<0.05）。TRPM7、TRPM8阳性表达患者3年生存率显著低于TRPM7、TRPM8阴性表达患者（P<0.05）。多因素Cox回归分析显示，淋巴结转移、TRPM7阳性表达、TRPM8阳性表达是BUC患者预后不良的独立危险因素（P<0.05）。结论：BUC组织中TRPM7和TRPM8的阳性表达与病理分期和淋巴结转移密切相关，且TRPM7、TRPM8阳性表达是BUC患者预后不良的独立危险因素。 |
| 英文摘要: |
| Objective:To investigate the relationship between the expression of transient receptor potential cation channel subfamily M member 7 (TRPM7) and transient receptor potential cation channel subfamily M member 8 (TRPM8) in bladder urothelial carcinoma (BUC) and clinicopathological features and prognosis. Methods:127 BUC patients in our hospital from January 2016 to December 2020 were selected as the research objects, and cancer tissues and adjacent tissues were retained during the operation. The expression of TRPM7 and TRPM8 in cancer tissues and adjacent tissues were compared, and the relationship between the expression of TRPM7 and TRPM8 in cancer tissues and clinicopathological features was analyzed. All BUC patients were followed up for 3 years, the survival difference between TRPM7 and TRPM8 positive and negative expression patients was analyzed by Kaplan-Meier curve, the influencing factors of death in BUC patients were analyzed by multivariate Cox regression model.Results:The positive expression rates of TRPM7 and TRPM8 in cancer tissues were significantly higher than those in adjacent tissues(P<0.05).The proportion of pathological stage T2~T4,and lymph node metastasis in patients with positive expression of TRPM7 and TRPM8 was significantly higher than that in patients with negative expression of TRPM7 and TRPM8 (P<0.05).The 3-year survival rate of patients with positive expression of TRPM7 and TRPM8 was significantly lower than that of patients with negative expression of TRPM7 and TRPM8 (P<0.05). Multivariate Cox regression analysis showed that, lymph node metastasis, TRPM7 positive expression and TRPM8 positive expression were independent risk factors for poor prognosis in BUC patients (P<0.05). Conclusion:The positive expression of TRPM7 and TRPM8 in BUC tissues are closely relate to pathological stage, and lymph node metastasis, and the positive expression of TRPM7 and TRPM8 are independent risk factors for poor prognosis in BUC patients. |
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