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| 血清CCR3、CCL7与结直肠癌根治术治疗患者术后复发转移的关系 |
| Relationship Between Serum CCR3, CCL7 and Postoperative Recurrence and Metastasis in Patients Undergoing Radical Resection of Colorectal Cancer |
| 投稿时间：2024-06-18 修订日期：2024-06-18 |
| DOI： |
| 中文关键词: 结直肠癌 CC趋化因子受体3 CC趋化因子配体7 复发转移 临床病理特征 |
| 英文关键词: Colorectal cancer CC chemokine receptor 3 CC chemokine ligand 7 Recurrence and metastasis Clinical pathological features |
| 基金项目:四川省科技计划项目重点研发计划（2022YFS0168） |
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| 中文摘要: |
| 目的 分析血清CC趋化因子受体3（CCR3）、CC趋化因子配体7（CCL7）与结直肠癌根治术治疗患者术后复发转移的关系。方法 于2018年3月至2020年3月选择川北医学院附属医院310例行结直肠癌根治术的患者为研究组，另取同期180例健康志愿者为对照组。采用双抗体酶联免疫吸附法测定血清CCR3、CCL7水平并作组间比较，分析血清CCR3、CCL7与临床病理特征的关系。患者随访3年，根据预后情况分为未复发转移组及复发转移组。分析术后复发转移的影响因素，探讨血清CCR3、CCL7对患者术后复发转移的预测价值。结果 与对照组相比，研究组血清CCR3、CCL7水平更高（P<0.05）。有淋巴结转移、TNM分期III期患者血清CCR3、CCL7水平显著高于无淋巴结转移、TNM分期I~II期患者（P<0.05）。复发转移组血清CCR3、CCL7水平显著高于未复发转移组（P<0.05）。结肠癌患者术后复发转移的危险因素包括淋巴结转移、CCR3升高、CCL7升高（P<0.05）。受试者工作特征（ROC）曲线结果显示：血清CCR3、CCL7联合预测结直肠癌术后复发转移的曲线下面积（AUC）为0.855，大于单一指标预测。结论 结直肠癌患者血清CCR3、CCL7水平升高，且是术后复发转移的危险因素；此外，CCR3、CCL7联合检测对患者术后复发转移的预测价值较高。 |
| 英文摘要: |
| Objective To analyze the relationship between serum CC chemokine receptor 3 (CCR3), CC chemokine ligand 7 (CCL7) and postoperative recurrence and metastasis in patients undergoing radical resection of colorectal cancer. Methods From March 2018 to March 2020, 310 patients who underwent radical resection of colorectal cancer in Affiliated Hospital of North Sichuan Medical College were selected as the study group, and 180 healthy volunteers during the same period were selected as the control group. Dual antibody enzyme-linked immunosorbent assay was used to determine serum levels of CCR3 and CCL7 and compared them between groups.The relationship between serum CCR3 and CCL7 and clinical pathological features was ananlyzed. The patients were followed up for 3 years and divided into non- recurrence and metastasis group and recurrence and metastasis group based on prognosis. The influencing factors of postoperative recurrence and metastasis were analyzed. The predictive value of serum CCR3 and CCL7 for postoperative recurrence and metastasis in patients was explored. Results Compared with the control group, the study group had higher levels of serum CCR3 and CCL7 (P<0.05). The serum levels of CCR3 and CCL7 in patients with lymph node metastasis and TNM stage III were significantly higher than those in patients without lymph node metastasis and TNM stage I~II (P<0.05). The serum levels of CCR3 and CCL7 in recurrence and metastasis group were significantly higher than those in non-recurrence and metastasis group (P<0.05). The risk factors for postoperative recurrence and metastasis in colorectal cancer patients included lymph node metastasis, elevated CCR3, and elevated CCL7 (P<0.05). The receiver operating characteristic (ROC) curve results showed that the area under the curve (AUC) of the combined prediction of serum CCR3 and CCL7 for postoperative recurrence and metastasis of colorectal cancer was 0.855, which was greater than that of single index prediction. Conclusion Elevated serum levels of CCR3 and CCL7 in colorectal cancer patients are risk factors for postoperative recurrence and metastasis; In addition, the combined detection of CCR3 and CCL7 has a high predictive value for postoperative recurrence and metastasis in patients. |
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