| Objective To analyze the relationship between serum microRNA (miR) -202, miR-34a expression and nosocomial infection in patients with primary liver cancer(PLC) after transcatheter arterial chemoembolization (TACE). Methods 975 patients with PLC who underwent TACE in our hospital from February 2020 to August 2023 were selected, the relative expression levels of serum miR-202 and miR-34a were determined by PCR.Patients were divided into infection group (n=80) and uninfected group (n=895) according to whether nosocomial infection occurred after TACE, the relative expression levels of serum miR-202 and miR-34a and clinical data were compared between two groups, the influencing factors of nosocomial infection in patients with PLC after TACE were analyzed by multivariate Logistic regression model, the value of serum miR-202, miR-34a and their combination in predicting nosocomial infection in patients with PLC after TACE were analyzed by receiver operating characteristic (ROC) curve. Results A total of 80 cases of nosocomial infection occurred in 975 patients with PLC, with an incidence of 8.21% (80/975). The relative expression levels of serum miR-202 and miR-34a in infected group were lower than those in uninfected group (P<0.05). The proportions of age≥60 years old, diabetes mellitus, ascites, non-preventive use of antibiotics, and interventional operation time≥120 min in infection group were higher than those in uninfected group (P<0.05). The age≥60 years old, diabetes mellitus, ascites, interventional operation time ≥120 min, and no prophylactic use of antibiotics were risk factors for nosocomial infection in patients with PLC after TACE (OR> 1, P<0.05), the increase in the relative expression of serum miR-202 and miR-34a were protective factor (OR<1, P<0.05). ROC curve showed that the AUC (95%CI) of serum miR-202, miR-34a and their combination in predicting nosocomial infection after TACE in patients with PLC were 0.852 (0.825-0.879), 0.737 (0.686-0.787) and 0.909 (0.885-0.933), respectively. Conclusion The expression of serum miR-202 and miR-34a in patients with PLC after TACE are low, the decreased expression of the two will increase the risk of nosocomial infection after TACE, and their combination can effectively predict the occurrence of nosocomial infection after TACE. |
