| 何 璨,徐 星,蒋建良,黄亚芳,汤 双,陈 云.经阴道彩色多普勒超声联合lncRNA CCAT1在上皮性卵巢癌诊断中的临床价值[J].,2024,(5):939-943 |
| 经阴道彩色多普勒超声联合lncRNA CCAT1在上皮性卵巢癌诊断中的临床价值 |
| Clinical Value of Transvaginal Color Doppler Ultrasound Combined with lncRNA CCAT1 in the Diagnosis of Epithelial Ovarian Cancer |
| 投稿时间：2023-08-23 修订日期：2023-09-17 |
| DOI：10.13241/j.cnki.pmb.2024.05.025 |
| 中文关键词: 上皮性卵巢癌 彩色多普勒超声 lncRNA CCAT1 诊断价值 |
| 英文关键词: Epithelial ovarian cancer Color Doppler ultrasound lncRNA CCAT1 Diagnostic value |
| 基金项目:湖南省医药卫生科研计划课题项目（B2015-77） |
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| 中文摘要: |
| 摘要 目的：探讨经阴道彩色多普勒超声联合血清长链非编码 RNA （lncRNA）结直肠相关转录本1（CCAT1）对上皮性卵巢癌的临床诊断价值。方法：以2020年5月至2022年5月本院收治的88例上皮卵巢肿瘤患者为研究对象，依据病理检查结果分为良性组（n=49）和恶性组（n=39）。对所有研究对象进行经阴道彩色多普勒超声检查及lncRNA CCAT1检测。采用受试者特征工作曲线（ROC）评价彩色多普勒超声参数联合血清lncRNA CCAT1对上皮性卵巢癌及其恶性程度的评估价值。结果：恶性组的阻力指数（RI）、搏动指数（PI）低于良性组，收缩期峰值血流速度（PSV）、舒张末期血流速度（EDV）及血清lncRNA CCAT1水平均高于良性组（P<0.05）；恶性组中Ⅲ~Ⅳ期患者的RI、PI低于Ⅰ~Ⅱ期患者，PSV、EDV及血清lncRNA CCAT1水平高于Ⅰ~Ⅱ期患者（P<0.05）。ROC分析结果显示，RI、PI、PSV、EDV及lncRNA CCAT1联合评价上皮性卵巢癌的曲线下面积（AUC）为0.977，联合评估效能均优于各指标单独评估；同时RI、PI、PSV、EDV及lncRNA CCAT1联合评价上皮性卵巢癌恶性程度的AUC为0.979，联合评估效能均优于各指标单独评估。结论：经阴道彩色多普勒超声联合血清lncRNA CCAT1检测对上皮性卵巢癌及其恶性程度均具有一定的评估价值，且各参数联合lncRNA CCAT1评估效能更佳。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of transvaginal color Doppler ultrasound combined with serum long non-coding RNA ( lncRNA ) colorectal related transcript 1 (CCAT1) in the diagnosis of epithelial ovarian cancer. Methods: A total of 88 patients with epithelial ovarian tumors admitted to our hospital from May 2020 to May 2022 were divided into benign group (n=49) and malignant group (n=39) according to the results of pathological examination. Transvaginal color Doppler ultrasonography and lncRNA CCAT1 detection were performed on all subjects. The receiver operating characteristic curve ( ROC ) was used to evaluate the value of color doppler ultrasound parameters combined with serum lncRNA CCAT1 in the evaluation of epithelial ovarian cancer and its malignancy. Results: The resistance index (RI) and pulsatility index (PI) in the malignant group were lower than those in the benign group, and the peak systolic blood flow velocity (PSV), end diastolic blood flow velocity (EDV) and serum lncRNA CCAT1 levels were higher than those in the benign group (P<0.05). In the malignant group, RI and PI in patients with III-IV stage were lower than those in patients with I-II stage, and PSV, EDV and serum lncRNA CCAT1 levels were higher than those in patients with stage I-II (P<0.05). ROC analysis showed that the area under the curve (AUC) of RI, PI, PSV, EDV and lncRNA CCAT1 in the combined evaluation of epithelial ovarian cancer was 0.977, and the combined evaluation efficiency was better than that of each index alone. At the same time, the AUC of RI, PI, PSV, EDV and lncRNA CCAT1 combined to evaluate the malignant degree of epithelial ovarian cancer was 0.979, and the combined evaluation efficiency was better than that of each index alone. Conclusion: Transvaginal color Doppler ultrasound combined with serum lncRNA CCAT1 detection has certain evaluation value for epithelial ovarian cancer and its malignancy, and each parameter combined with lncRNA CCAT1 has better evaluation efficiency. |
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