| 杨冬文,辛汉城,陈岳峰,林少胜,黄 铿.血清HMGB1、AT和炎性因子在急性创伤患者中表达水平及其与血栓形成的相关性分析[J].,2024,(5):904-909 |
| 血清HMGB1、AT和炎性因子在急性创伤患者中表达水平及其与血栓形成的相关性分析 |
| The Expression Levels of Serum HMGB1, AT and Inflammatory Factors in Patients with Acute Trauma and their Correlation with Thrombosis were Analyzed |
| 投稿时间：2023-08-09 修订日期：2023-08-31 |
| DOI：10.13241/j.cnki.pmb.2024.05.018 |
| 中文关键词: 急性创伤 HMGB1 AT 炎性因子 血栓形成 相关性 |
| 英文关键词: Acute trauma HMGB1 AT Inflammatory factors Thrombosis Correlation |
| 基金项目:广东省感染病与分子免疫病理重点实验室开放课题（GDKL202203） |
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| 中文摘要: |
| 摘要 目的：分析血清高迁移率族蛋白B1（HMGB1）、抗凝血酶（AT）和炎性因子在急性创伤患者中表达水平及其与血栓形成的相关性。方法：将2020年1月～2022年12月本院收治的90例急性创伤患者纳入观察组，记录其血栓形成率，另将同期在本院进行体检的50例健康体检者纳入对照组，分别检测观察组、对照组及有无血栓形成患者的血清HMGB1、AT和炎性因子[白介素-6（IL-6）、白介素-10（IL-10）、白介素-1β（IL-1β）]水平；采用双变量Spearman相关性法检验血清HMGB1、AT和炎性因子与血栓形成的相关性；建立多因素Logistic模型分析影响急性创伤患者血栓形成的独立危险因素；分析血清HMGB1、AT和炎性因子在急性创伤患者血栓形成中的预测效能。结果：与对照组比较，观察组血清HMGB1、IL-6、IL-10、IL-1β水平较高，血清AT水平较低（P＜0.05）。与无血栓组比较，血栓组血清HMGB1、IL-6、IL-10、IL-1β水平较高，血清AT水平较低（P＜0.05）。急性创伤患者血栓形成与血清HMGB1、IL-6、IL-10、IL-1β呈正相关性，与血清AT呈负相关性（P＜0.05）。多因素Logistic分析结果显示，血清HMGB1、AT、IL-6、IL-10、IL-1β均是导致急性创伤患者血栓形成的独立危险因素（P＜0.05）。血清HMGB1、AT、HMGB1+AT+炎性因子对急性创伤患者血栓形成的预测值较高，AUC值分别为0.868、0.857、0.912；血清IL-6、IL-10、IL-1β对急性创伤患者血栓形成的预测值一般，AUC值分别为0.761、0.758、0.784、0.767。结论：血清HMGB1、AT和炎性因子与急性创伤及其血栓形成均存在一定关联，可根据其指标水平变化评估并预测急性创伤患者的损伤情况和血栓形成风险。 |
| 英文摘要: |
| ABSTRACT Objective: The expression levels of serum high mobility group protein B1 (HMGB1), antithrombin (AT) and inflammatory factors in patients with acute trauma and their correlation with thrombosis were analyzed. Methods: 90 patients with acute trauma admitted to our hospital from January 2020 to December 2022 were included in the observation group, and the thrombosis rate was recorded. In addition, 50 healthy subjects who underwent physical examination in our hospital during the same period were included in the control group. The levels of serum HMGB1, AT and inflammatory factors [interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-1β (IL-1)] in the observation group, the control group and patients with or without thrombosis were detected. The correlation between serum HMGB1, AT and inflammatory factors and thrombosis was tested by bivariate Spearman correlation method. Multivariate Logistic model was established to analyze the independent risk factors of thrombosis in patients with acute trauma. The predictive efficacy of serum HMGB1, AT and inflammatory factors in thrombosis in patients with acute trauma was analyzed. Results: Compared with the control group, the serum levels of HMGB1, IL-6, IL-10 and IL-1β in the observation group were higher, and the serum AT level was lower (P<0.05). Compared with the non-thrombosis group, the serum levels of HMGB1, IL-6, IL-10 and IL-1β in the thrombus group were higher, and the serum AT level was lower (P<0.05). Thrombosis in patients with acute trauma was positively correlated with serum HMGB1, IL-6, IL-10 and IL-1β, and negatively correlated with serum AT (P<0.05). Multivariate Logistic analysis showed that serum HMGB1, AT, IL-6, IL-10 and IL-1β were independent risk factors for thrombosis in patients with acute trauma (P<0.05). The predictive value of serum HMGB1, AT, HMGB1 + AT + inflammatory factors for thrombosis in patients with acute trauma was higher, and the AUC values were 0.868,0.857 and 0.912, respectively. The predictive value of serum IL-6, IL-10 and IL-1β for thrombosis in patients with acute trauma was general, and the AUC values were 0.761, 0.758, 0.784 and 0.767, respectively. Conclusion: Serum HMGB1, AT and inflammatory factors are associated with acute trauma and thrombosis. The injury and thrombosis risk of patients with acute trauma can be evaluated and predicted according to the changes of their index levels. |
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