| 谢爱萍,黄 敏,刘小凤,陈 相,李 恬.三维能量多普勒超声联合血清HE4、TK1、YKL-40对绝经后出血患者子宫内膜癌的预测价值[J].,2024,(3):574-577 |
| 三维能量多普勒超声联合血清HE4、TK1、YKL-40对绝经后出血患者子宫内膜癌的预测价值 |
| Predictive Value of Three-Dimensional Energy Doppler Ultrasound Combined with Serum HE4, TK1 and YKL-40 for Endometrial Cancer in Postmenopausal Bleeding Patients |
| 投稿时间：2023-07-06 修订日期：2023-07-30 |
| DOI：10.13241/j.cnki.pmb.2024.03.033 |
| 中文关键词: 三维能量多普勒超声 HE4 TK1 YKL-40 绝经后出血 子宫内膜癌 预测价值 |
| 英文关键词: Three-dimensional energy Doppler ultrasound HE4 TK1 YKL-40 Postmenopausal bleeding Endometrial cancer Predictive value |
| 基金项目:湖南省卫生健康委科研计划项目（D20230926855） |
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| 中文摘要: |
| 摘要 目的：研究三维能量多普勒超声联合血清人附睾蛋白4（HE4）、胸苷激酶1（TK1）、甲壳质酶蛋白40（YKL-40）对绝经后出血患者子宫内膜癌的预测价值。方法：选择我院2019年10月～2022年10月收治的150例绝经后出血患者。将其按照病理检查结果的差异分为子宫内膜癌组31例与子宫内膜良性增生组119例。对所有患者均开展三维能量多普勒超声检查，并检测血清HE4、TK1、YKL-40水平。以受试者工作特征曲线（ROC）分析三维能量多普勒超声联合血清HE4、TK1、YKL-40水平预测绝经后出血患者子宫内膜癌的效能。结果：子宫内膜癌组血流指数（FI）、血管形成指数（VI）、血管形成-血流指数（VFI）以及由该三参数构建的综合指数I相较于子宫内膜良性增生组均更高（均P＜0.05）。子宫内膜癌组血清HE4、TK1、YKL-40水平相较于子宫内膜良性增生组均更高（均P＜0.05）。经ROC曲线分析发现：三维能量多普勒超声联合血清HE4、TK1、YKL-40水平预测绝经后出血患者子宫内膜癌的曲线下面积（AUC）、灵敏度、特异度以及约登指数均高于上述四项单独预测。结论：三维能量多普勒超声联合血清HE4、TK1、YKL-40水平预测绝经后出血患者子宫内膜癌的效能较佳。 |
| 英文摘要: |
| ABSTRACT Objective: To study the predictive value of three-dimensional energy Doppler ultrasound combined with serum human epididymal protein 4 (HE4), thymidine kinase 1 (TK1) and chitinase protein 40 (YKL-40) for endometrial cancer in postmenopausal bleeding patients. Methods: 150 postmenopausal bleeding patients who were admitted from October 2019 to October 2022 in the our hospital were selected. They were divided into endometrial carcinoma group (31 cases) and endometrial benign hyperplasia group (119 cases) according to the difference of pathological examination results. Three-dimensional energy Doppler ultrasound was performed in all patients, and serum HE4, TK1, YKL-40 levels were detected. The efficacy of three-dimensional energy Doppler ultrasound combined with serum HE4, TK1, and YKL-40 levels in predicting endometrial cancer in postmenopausal bleeding patients was analyzed by receiver operating characteristic curve (ROC). Results: Blood flow index (FI), angiogenesis index (VI), angiogenesis - blood flow index (VFI) and the composite index I constructed by these three parametersin endometrial cancer group were higher than those in endometrial benign hyperplasia group (all P<0.05). The serum levels of HE4, TK1 and YKL-40 in endometrial cancer group were higher than those in endometrial benign hyperplasia group (all P<0.05). Through ROC curve analysis found that the area under the curve(AUC), sensitivity, specificity and Yoden index of three-dimensional energy Doppler ultrasound combined with serum HE4, TK1 and YKL-40 levels in predicting endometrial cancer in postmenopausal bleeding patients were higher than those of the four independent predictions. Conclusion: Three-dimensional energy Doppler ultrasound combined with serum HE4, TK1 and YKL-40 levels were more effective in predicting endometrial cancer in postmenopausal bleeding patients. |
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