| 彭飞飞,观 云,田雪娇,韩培英,郭 洁.宣肺解痉清热方治疗青年热哮患者疗效及其预后影响因素分析[J].,2024,(3):568-573 |
| 宣肺解痉清热方治疗青年热哮患者疗效及其预后影响因素分析 |
| Analysis on The Curative Effect and Prognostic Factors of Xuanfei Jieasmolasqingrefang in the Treatment of Young Patients with Heat Asthma |
| 投稿时间：2023-06-10 修订日期：2023-06-30 |
| DOI：10.13241/j.cnki.pmb.2024.03.032 |
| 中文关键词: 宣肺解痉清热方 青年患者 热哮喘 预后 |
| 英文关键词: Xuanfei Jieasmolasqingrefang Young Patients Heat asthma Prognosis |
| 基金项目:河北省中医药管理局科研计划项目（2020025） |
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| 中文摘要: |
| 摘要 目的：探究宣肺解痉清热方治疗青年热哮患者疗效及其预后影响因素。方法：选择2019年10月~2021年9月本院收治的60例青年热哮患者为本次研究对象，依据不同治疗方法将其分为2组，观察组，n=30，对照组，n=30。对照组在吸氧、化痰等常规治疗基础上，依据其严重程度，开展布地奈德福莫特罗粉吸入剂治疗。观察组在对照组基础上，增加宣肺解痉清热方辅助治疗。比较组间治疗前后相关因子、成人哮喘生存质量评分表（AQLQ）、治疗效果，并依据患者预后效果，将其分为预后良好组（n=40）及预后不佳组（n=20），对热哮患者预后予以单因素分析，并开展Logistic回归分析，判断影响预后的独立因素。结果：治疗前，观察组及对照组白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）、FEV第1秒用力呼气容积/用力肺活量（FEV1/FVC）水平及AQLQ评分比较无差异（P＞0.05），治疗后，与治疗前比较，IL-4水平均降低，且观察组水平更低，IFN-γ水平、FEV1/FVC水平及AQLQ评分均升高，且观察组水平更高（P＜0.05）；观察组治疗有效率较对照组高（P＜0.05）；青年热哮预后影响因素分析中，结果显示，病程、BMI、过敏性鼻炎、遗传因素、起病年龄、呼吸道感染次数、吸烟史、发作频率等因素均是影响热哮预后的单因素（P＜0.05），依从性、皮肤湿疹、给药途径均未对热哮预后效果产生较大影响（P＞0.05）；将影响热哮预后的单因素予以赋值，纳入Logistic回归分析，以病程、BMI、过敏性鼻炎、遗传因素、起病年龄、呼吸道感染次数、吸烟史、发作频率为自变量，结果显示，病程、BMI、过敏性鼻炎、遗传因素、吸烟史、发作频率是影响热哮预后的独立因素（P＜0.05）。结论：宣肺解痉清热方可有效调节青年热哮患者机体炎症因子及肺功能，提高生活质量及治疗效果，依据热哮患者预后效果，病程、BMI、过敏性鼻炎、遗传因素、吸烟史、发作频率是影响热哮预后的独立因素，可予以针对性干预，以提升患者预后效果。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy and prognostic factors of Xuanfei Jiaoji Qingre decoction in the treatment of young patients with hot wheezing. Methods: Sixty young patients with febrile croup admitted to our hospital from October 2019 to September 2021 were selected as the subjects of this study, and they were divided into 2 groups according to different treatment methods, observation group, n=30, and control group, n=30. The control group was treated with budesonide formoterol powder inhalation based on their severity on the basis of conventional treatment such as oxygenation and sputum dissolution. In the observation group, based on the control group, the adjuvant treatment of Xuanfei antispasmodic and clearing heat formula was added. The relevant factors, adult asthma survival quality rating scale (AQLQ) and treatment effect were compared before and after treatment between the groups, and the patients were divided into good prognosis group (n=40) and poor prognosis group (n=20) according to their prognosis effect, and the prognosis of patients with febrile croup was analyzed unilaterally and logistic regression analysis was conducted to determine the independent factors affecting prognosis. Results: Before treatment, there was no difference in the comparison of interleukin-4 (IL-4), interferon-γ (IFN-γ), FEV1 st second expiratory volume/exertional spirometry (FEV1/FVC) levels and AQLQ scores between the observation and control groups(P>0.05), after treatment, compared with before treatment, IL-4 levels were lower in the observation group, and IFN-γ levels, FEV1/FVC levels and AQLQ scores were higher in the observation group, and the levels were higher in the observation group (P<0.05);Treatment group effective rate in the observation group was higher than control group(P<0.05); In the analysis of influencing factors for the prognosis of hot wheezing in adolescents, the results showed that the course of disease, BMI, allergic rhinitis, genetic factors, age of onset, number of respiratory tract infections, smoking history, and frequency of attacks were all single factors affecting the prognosis of hot wheezing(P<0.05). Compliance, skin eczema and route of administration did not have a great influence on the prognosis of hot wheeze (P>0.05). The single factors affecting the prognosis of heat asthma were assigned values and included in the Logistic regression analysis. The course of disease, BMI, allergic rhinitis, genetic factors, age of onset, frequency of respiratory tract infection, smoking history and frequency of attack were used as independent variables. Course, BMI, allergic rhinitis, genetic factors, smoking history, seizure frequency is the independent factors influencing the prognosis of hot xiao (P<0.05). Conclusion: Xuanfei spasmolysis heat can effectively regulate young fever patients body inflammation factor and lung function, improve the quality of life and treatment effect, according to the prognosis of effect in patients with fever, course, BMI, allergic rhinitis, genetic factors, smoking history, attack frequency is an independent factor affecting the prognosis of fever, can be targeted intervention, to improve the prognosis effect in patients. |
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