| 吴 越,李 强,谭明帅,谭 伟,陈 泽.基于PI3K/Akt信号通路探讨桃红四物汤促进老年股骨粗隆间骨折患者PFNA术后骨折愈合的疗效及其机制[J].,2024,(1):176-179 |
| 基于PI3K/Akt信号通路探讨桃红四物汤促进老年股骨粗隆间骨折患者PFNA术后骨折愈合的疗效及其机制 |
| Explore the Effect and Mechanism of Taohong Siwu Decoction on Promoting Fracture Healing after PFNA in Elderly Patients with Fntertrochanteric Fracture Based on PI3K/Akt Signaling Pathway |
| 投稿时间：2023-06-03 修订日期：2023-06-26 |
| DOI：10.13241/j.cnki.pmb.2024.01.035 |
| 中文关键词: PI3K/Akt信号通路 桃红四物汤 老年 股骨粗隆间骨折 股骨近端抗旋髓内钉术 骨折愈合 |
| 英文关键词: PI3K/Akt signaling pathway Taohong siwu decoction Elderly Fntertrochanteric fracture Proximal femoral nail antirotation Fracture healing |
| 基金项目:四川省中医药管理局科学技术研究专项课题（2020LC0223） |
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| 中文摘要: |
| 摘要 目的：基于磷酯酰肌醇3激酶（PI3K）/丝氨酸蛋白激酶（Akt）信号通路探讨桃红四物汤促进老年股骨粗隆间骨折患者股骨近端抗旋髓内钉（PFNA）术后骨折愈合的疗效及其机制。方法：选取2021年7月-2022年12月期间遂宁市中医院收治的90例老年股骨粗隆间骨折行PFNA术患者，按照随机数字表法将患者分为对照组和研究组，各为45例。对照组术后接受常规干预，研究组在对照组基础上接受桃红四物汤干预。对比两组中医证候积分、骨折愈合时间、Harris髋关节功能评分、血液流变学、PI3K/Akt信号通路相关指标。结果：治疗后研究组髋部疼痛、痛有定处、神疲乏力、患肢软而无力、头晕眼花、失眠健忘、自汗畏风寒、胸闷气短、肌肤甲错、面色晄白无华评分和总分低于对照组（P<0.05）。研究组的骨折愈合时间短于对照组，Harris髋关节功能评分高于对照组（P<0.05）。研究组的红细胞压积、血浆比黏度、全血比黏度、红细胞电泳时间低于对照组（P<0.05）。研究组治疗后PI3K mRNA、AktmRNA高于对照组（P<0.05）。结论：老年股骨粗隆间骨折患者PFNA术后使用桃红四物汤，可促进患者临床预后转归，降低中医证候积分，促进髋关节功能恢复，缩短骨折愈合时间，改善机体血液流变学，调节PI3K/Akt信号通路表达。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy and mechanism of taohong siwu decoction on promoting fracture healing after proximal femoral nail antirotation (PFNA) in elderly patients with fntertrochanteric fracture based on phosphatidylinositol 3-kinase (PI3K)/serine protein kinase (Akt) signaling pathway. Methods: 90 elderly patients with fntertrochanteric fracture treated with PFNA who were admitted to Suining Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were selected, patients were divided into control group and study group according to the random number table method, 45 cases each. Control group received routine intervention after operation, and study group received taohong siwu decoction on the basis of control group. The traditional Chinese medicine syndrome scores, fracture healing time, Harris hip function scores, hemorheology, PI3K/Akt signaling pathway related indicators were compared between two groups. Results: The hip pain, pain, fatigue, limb weakness, dizziness, insomnia, forgetfulness, spontaneous sweating, fear of wind and cold, chest tightness, shortness of breath, skin nails, pale complexion score and total score in study group were lower than those in control group after treatment(P<0.05). The fracture healing time in study group was shorter than that in control group, Harris hip function score was higher than that of control group(P<0.05). The hematocrit, plasma specific viscosity, whole blood specific viscosity and erythrocyte electrophoresis time in study group were lower than those in control group(P<0.05). PI3K mRNA and Akt mRNA in study group were higher than those in control group after treatment(P<0.05). Conclusion: Elderly patients with fntertrochanteric fracture are treat with taohong siwu decoction after PFNA surgery, which can promote the clinical prognosis of patients, reduce traditional Chinese medicine syndrome scores, promote the recovery of hip joint function, shorten the healing time of fractures, improve hemorheology of the body, and regulate the expression of PI3K/Akt signaling pathway. |
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