| 王 婷,程秋雁,张俐可欣,胡 楠,黄海涛.益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响[J].,2024,(1):117-120 |
| 益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响 |
| Effects of Yixinshu Tablets Combined with Metoprolol on Cardiac Function, Hemorheology and Vascular Endothelial Function in Patients with Angina Pectoris of Coronary Heart Disease |
| 投稿时间：2023-06-30 修订日期：2023-07-24 |
| DOI：10.13241/j.cnki.pmb.2024.01.022 |
| 中文关键词: 益心舒片 美托洛尔 冠心病心绞痛 心功能 血液流变学 血管内皮功能 |
| 英文关键词: Yixinshu tablets Metoprolol Angina pectoris of coronary heart disease Cardiac function Hemorheology Vascular endothelial function |
| 基金项目:江苏省药学会-奥赛康医院药学基金科研项目（A201920） |
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| 中文摘要: |
| 摘要 目的：探讨益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响。方法：纳入南京市中心医院2020年7月~2022年8月期间收治的冠心病心绞痛患者126例。采用随机数字表法分为对照组（n=63，接受美托洛尔治疗）和研究组（n=63，对照组基础上接受益心舒片治疗）。对比两组临床症状、心功能[左心室射血分数（LVEF）、心输出量（CO）、左室舒张末期内径（LVEDD）]、血液流变学[血浆黏度、全血高切黏度、全血低切黏度]和血管内皮功能[一氧化氮（NO）、内皮素-1（ET-1）]变化情况，同时观察两组不良反应发生率。结果：两组治疗12周后心绞痛发作次数减少，心绞痛持续时间缩短，研究组的改善幅度大于对照组（P<0.05）。两组治疗12周后CO、LVEF升高，LVEDD缩小，研究组的改善幅度大于对照组（P<0.05）。两组治疗12周后血浆黏度、全血高切黏度、全血低切黏度下降，研究组的改善幅度大于对照组（P<0.05）。两组治疗12周后ET-1下降，NO升高，研究组的改善幅度大于对照组（P<0.05）。对照组（4.76%）、研究组（6.35%）的不良反应发生率组间对比未见差异（P>0.05）。结论：益心舒片联合美托洛尔治疗冠心病心绞痛患者，可有效改善患者的血液流变学、心功能和血管内皮功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of yixinshu tablets combined with metoprolol on cardiac function, hemorheology and vascular endothelial function in patients with angina pectoris of coronary heart disease. Methods: 126 patients with angina pectoris of coronary heart disease who were admitted to Nanjing Central Hospital from July 2020 to August 2022 were included. Patients were divided into control group (n=63, treated with metoprolol) and study group (n=63, treated with yixinshu tablets on the basis of control group) by random number table method. The changes of clinical symptoms, cardiac function [left ventricular ejection fraction (LVEF), cardiac output (CO), left ventricular end diastolic diameter (LVEDD)], hemorheology [plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity] and vascular endothelial function [nitric oxide (NO), endothelin-1 (ET-1)] were compared between two groups, and the incidence of adverse reactions in two groups were observed. Results: 12 weeks after treatment, the number of angina pectoris attacks decreased and the duration of angina pectoris shortened in two groups, the improvement in study group was greater than that in control group (P<0.05). 12 weeks after treatment, CO and LVEF increased and LVEDD decreased in two groups, and the improvement in study group was greater than that in control group(P<0.05). 12 weeks after treatment, the plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity in two groups decreased, and the improvement in study group was greater than that in control group(P<0.05). 12 weeks after treatment, ET-1 decreased and NO increased in two groups, and the improvement in study group was greater than that in control group(P<0.05). There was no difference in the incidence of adverse reactions between control group (4.76%) and study group(6.35%)(P>0.05). Conclusion: Yixinshu tablets combined with metoprolol can effectively improve the hemorheology, cardiac function, and endothelial function of patients with coronary heart disease and angina pectoris. |
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