文章摘要
吴 琼,李 妍,党冠星,蒋慧莉,刘洪雷.血清sE-sel、HIF-1α、MCP-1与糖尿病患者白内障超声乳化术后黄斑水肿的关系研究[J].,2023,(24):4746-4750
血清sE-sel、HIF-1α、MCP-1与糖尿病患者白内障超声乳化术后黄斑水肿的关系研究
Study of the Relationship between Serum sE-sel, HIF-1α, MCP-1 and Macular Edema after Cataract Phacoemulsification in Diabetic Patients
投稿时间:2023-06-24  修订日期:2023-07-20
DOI:10.13241/j.cnki.pmb.2023.24.029
中文关键词: 糖尿病  白内障超声乳化术  sE-sel  HIF-1α  MCP-1  黄斑水肿
英文关键词: Diabetes  Cataract Phacoemulsification  sE-sel  HIF-1α  MCP-1  Macular edema
基金项目:陕西省重点研发计划项目(2021SF-164)
作者单位E-mail
吴 琼 西北大学附属人民医院/西安市人民医院(西安市第四医院眼科) 陕西 西安 710004 wqofriend@163.com 
李 妍 西北大学附属人民医院/西安市人民医院(西安市第四医院眼科) 陕西 西安 710004  
党冠星 西北大学附属人民医院/西安市人民医院(西安市第四医院眼科) 陕西 西安 710004  
蒋慧莉 西北大学附属人民医院/西安市人民医院(西安市第四医院眼科) 陕西 西安 710004  
刘洪雷 西北大学附属人民医院/西安市人民医院(西安市第四医院眼科) 陕西 西安 710004  
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中文摘要:
      摘要 目的:探讨血清可溶性E-选择素(sE-sel)、缺氧诱导因子-1α(HIF-1α)、单核细胞趋化蛋白-1(MCP-1)与糖尿病患者白内障超声乳化术(Phaco)后黄斑水肿的关系。方法:选取2021年1月~2023年1月在西安市第四医院行白内障Phaco治疗的糖尿病性白内障患者167例作为糖尿病性白内障组,根据术后3个月是否发生黄斑水肿分为黄斑水肿组35例和无黄斑水肿组132例,另选取同期87名单纯2型糖尿病(T2DM)患者作为T2DM组。采用酶联免疫吸附法检测血清sE-sel、HIF-1α、MCP-1水平。多因素Logistic回归分析影响糖尿病患者白内障Phaco后黄斑水肿的因素,受试者工作特征(ROC)曲线分析血清sE-sel、HIF-1α、MCP-1水平对糖尿病患者白内障Phaco后黄斑水肿的预测价值。结果:糖尿病性白内障组血清sE-sel、HIF-1α、MCP-1水平高于T2DM组(P<0.05)。167例糖尿病性白内障患者白内障Phaco后3个月黄斑水肿发生率20.96%。多因素Logistic回归显示,T2DM病程延长、增殖型糖尿病视网膜病变(DR)和HbA1c、sE-sel、HIF-1α、MCP-1升高为影响糖尿病患者白内障Phaco后黄斑水肿的独立危险因素(P<0.05)。ROC曲线分析显示,血清sE-sel、HIF-1α、MCP-1水平联合预测糖尿病患者白内障Phaco后黄斑水肿的曲线下面积为0.936,大于血清sE-sel、HIF-1α、MCP-1水平单独预测的0.768、0.775、0.773。结论:血清sE-sel、HIF-1α、MCP-1水平升高是影响糖尿病患者白内障Phaco后黄斑水肿的独立危险因素,血清sE-sel、HIF-1α、MCP-1水平联合预测糖尿病患者白内障Phaco后黄斑水肿的价值较高。
英文摘要:
      ABSTRACT Objective: To investigate the relationship between serum soluble E-selectin (sE-sel), hypoxia-inducible factor-1α (HIF-1α), monocyte chemotactic protein-1 (MCP-1) and macular edema after cataract phacoemulsification (Phaco) in diabetic patients. Methods: 167 diabetic cataract patients who underwent cataract Phaco treatment in the Xi'an Fourth Hospital from January 2021 to January 2023 were selected as diabetic cataract group, patients were divided into macular edema group (35 cases) and non-macular edema group (132 cases) ccording to whether macular edema occurred 3 months after operation, and another 87 patients with simple type 2 diabetes mellitus (T2DM) were selected as T2DM group. The levels of serum sE-sel, HIF-1α and MCP-1 were detected by enzyme-linked immunosorbent assay. The factors affecting macular edema after cataract Phaco in diabetic patients were analyzed by multivariate Logistic regression analysis, the predictive value of serum sE-sel, HIF-1α and MCP-1 levels for macular edema after cataract Phaco in diabetic patients were analyzed by receiver operating characteristic (ROC) curve. Results: The levels of serum sE-sel, HIF-1α and MCP-1 in diabetic cataract group were higher than those in T2DM group(P<0.05). The incidence of macular edema in 167 patients with diabetic cataract was 20.96% in 3 months after cataract Phaco. Multivariate logistic regression showed that, prolonged course of T2DM, proliferative diabetic retinopathy (DR) and elevated levels of HbA1c, sE-sel, HIF-1α and MCP-1 were independent risk factors for macular edema after cataract Phaco in diabetic patients (P<0.05). ROC curve analysis showed that, the area under the curve of serum sE-sel, HIF-1α and MCP-1 levels combined to predict macular edema after cataract Phaco in diabetic patients was 0.936, which was greater than 0.768, 0.775 and 0.773 predicted by serum sE-sel, HIF-1α and MCP-1 levels alone. Conclusion: The increase of serum sE-sel, HIF-1α and MCP-1 levels are independent risk factors affecting macular edema after cataract Phaco in diabetic patients, the combination of serum sE-sel, HIF-1α and MCP-1 levels has a higher value in predicting macular edema after cataract Phaco in diabetic patients.
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