| 刘 静,刘翠云,马金海,卫雪利,汤长超.血清GPAA1、SF、OPN与儿童急性淋巴细胞白血病危险度的关系及对血栓发生风险的评估效能研究[J].,2023,(23):4488-4491 |
| 血清GPAA1、SF、OPN与儿童急性淋巴细胞白血病危险度的关系及对血栓发生风险的评估效能研究 |
| The Relationship between Serum GPAA1, SF, OPN and the Risk of Acute Lymphoblastic Leukemia in Children and the Efficacy of Evaluating the Risk of Thrombosis |
| 投稿时间：2023-06-10 修订日期：2023-06-27 |
| DOI：10.13241/j.cnki.pmb.2023.23.017 |
| 中文关键词: 儿童 急性淋巴细胞白血病 糖基磷脂酰肌醇锚附着蛋白1 铁蛋白 骨桥蛋白 |
| 英文关键词: Children Acute lymphoblastic leukemia Glycosylphosphatidylinositol anchor attachment protein 1 Ferritin Osteopontin |
| 基金项目:宁夏自然科学基金项目（2021A0968） |
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| 中文摘要: |
| 摘要 目的：分析血清糖基磷脂酰肌醇锚附着蛋白1（GPAA1）、铁蛋白（SF）、骨桥蛋白（OPN）与儿童急性淋巴细胞白血病危险度的关系及对血栓发生风险的评估效能。方法：选择我院自2017年1月至2022年12月接诊的112例急性淋巴细胞白血病患儿作为观察组，另选112例性别、年龄与观察组相匹配的健康体检儿童作为对照组。检测两组血清GPAA1、SF、OPN表达水平，分析不同危险度的急性淋巴细胞白血病患儿血清GPAA1、SF、OPN表达水平的差异性，观察急性淋巴细胞白血病患儿的血栓发生情况，通过受试者工作特征曲线（ROC）下面积（AUC）评价血清GPAA1、SF、OPN预测急性淋巴细胞白血病患儿发生血栓的效能。结果：观察组血清GPAA1、SF、OPN表达水平均高于对照组（P＜0.05）；在低危、中危和高危的急性淋巴细胞白血病患儿中，血清GPAA1、SF、OPN表达水平有差异（P＜0.05）；经Spearman相关性分析，血清GPAA1、SF、OPN表达水平与儿童急性淋巴细胞白血病危险度呈正相关（P＜0.05）；在112例急性淋巴细胞白血病患儿中，发生血栓12例，占10.71%；经多因素Logistic回归分析，血清GPAA1、SF、OPN均是急性淋巴细胞白血病患儿发生血栓的独立预测因素（P＜0.05）；经ROC曲线分析，血清GPAA1、SF联合OPN预测急性淋巴细胞白血病患儿发生血栓的AUC为0.901。结论：血清GPAA1、SF、OPN与儿童急性淋巴细胞白血病危险度密切相关，联合预测患儿发生血栓的效能较好，对此病的诊治具有重要指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum glycosylphosphatidylinositol anchor attachment protein 1(GPAA1), ferritin (SF), osteopontin (OPN) and the risk of acute lymphoblastic leukemia in children and evaluate the risk of thrombosis. Methods: 112 children with acute lymphoblastic leukemia admitted to our hospital from January 2017 to December 2022 were selected as the observation group, and 112 healthy children matching the gender and age of the observation group were selected as the control group.The expression levels of serum GPAA1, SF and OPN in the two groups were detected, the differences in the expression levels of serum GPAA1, SF and OPN in children with acute lymphoblastic leukemia with different risk levels were analyzed, and the occurrence of thrombosis in children with acute lymphoblastic leukemia was observed.The area under receiver operating characteristic curve (ROC) (AUC) was used to evaluate the efficacy of serum GPAA1, SF and OPN in predicting thrombus occurrence in children with acute lymphoblastic leukemia. Results: The expression levels of serum GPAA1, SF and OPN in observation group were higher than those in control group (P<0.05). The expression levels of serum GPAA1,SF and OPN in children with low-risk,medium-risk and high-risk acute lymphoblastic leukemia were significant (P<0.05). The expression levels of serum GPAA1, SF and OPN were positively correlated with the risk of childhood acute lymphoblastic leukemia by Spearman correlation analysis (P<0.05). Among 112 children with acute lymphoblastic leukemia, thrombosis occurred in 12 cases (10.71%). Multivariate Logistic regression analysis showed that serum GPAA1,SF and OPN were independent predictors of thrombosis in children with acute lymphoblastic leukemia (P<0.05). According to ROC curve analysis, the AUC of serum GPAA1 and SF combined with OPN to predict thrombus occurrence in children with acute lymphoblastic leukemia was 0.901. Conclusion: Serum GPAA1, SF and OPN are closely related to the risk of acute lymphoblastic leukemia in children, and the combination of GPAA1, SF and OPN is effective in predicting thrombus occurrence in children, which has important guiding significance in the diagnosis and treatment of this disease. |
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