| 许惠娟,林钊钒,杨妙红,王书倩,陈佳丽,余汉光.单吸入器三联疗法联合肺早期康复运动训练治疗中重度慢性阻塞性肺疾病患者的临床研究[J].,2023,(23):4478-4481 |
| 单吸入器三联疗法联合肺早期康复运动训练治疗中重度慢性阻塞性肺疾病患者的临床研究 |
| Clinical Study of Single Inhaler Triple Therapy Combined with Early Pulmonary Rehabilitation Exercise Training for the Treatment in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease |
| 投稿时间：2023-06-01 修订日期：2023-06-24 |
| DOI：10.13241/j.cnki.pmb.2023.23.015 |
| 中文关键词: 单吸入器三联疗法 康复运动训练 中重度 慢性阻塞性肺疾病 |
| 英文关键词: Single inhaler triple therapy Rehabilitation exercise training Moderate to severe Chronic obstructive pulmonary disease |
| 基金项目:广东省医学科学技术研究基金项目（A2022429） |
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| 中文摘要: |
| 摘要 目的：探讨单吸入器三联疗法联合肺早期康复运动训练治疗中重度慢性阻塞性肺疾病（COPD）患者的临床研究。方法：根据随机数字表法，将汕头大学医学院第二附属医院2022年7月-2023年1月间收治的84例中重度COPD患者分为对照组（42例，单吸入器三联疗法治疗）和实验组（42例，对照组的基础上接受肺早期康复运动训练治疗）。观察并对比两组的肺功能指标[用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、FEV1/FVC]、血气分析指标[血氧饱和度（SaO2）、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）]、6分钟步行距离（6MWD）、COPD评估测试（CAT）评分、治疗期间急性加重频率、血清炎症因子[肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、C反应蛋白（CRP）]。结果：治疗后，实验组FEV1、FVC、FEV1/FVC高于对照组（P<0.05）。治疗后，实验组PaCO2低于对照组，PaO2、SaO2高于对照组（P<0.05）。治疗后，实验组6MWD高于对照组，CAT评分、治疗期间急性加重频率低于对照组（P<0.05）。治疗后，实验组血清TNF-α、IL-6、CRP水平低于对照组（P<0.05）。结论：单吸入器三联疗法联合肺早期康复运动训练治疗中重度COPD患者，可增强运动耐力，提高生活活动能力，减少治疗期间疾病急性加重频率，同时还可改善血气分析和肺功能指标，降低血清炎症因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical study of single inhaler triple therapy combine with early pulmonary rehabilitation exercise training for the treatment in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Methods: According to the random number table method, 84 patients with moderate to severe COPD who were admitted to The Second Affiliated Hospital of Shantou University Medical College from July 2022 to January 2023 were divided into control group (42 cases, treated with single inhaler triple therapy) and experimental group (42 cases, treated with early pulmonary rehabilitation exercise training on the basis of control group). The pulmonary function indicators [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC], blood gas analysis indicators [degree of blood oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2)], 6-minute walking distance (6MWD), COPD assessment test (CAT) scores, frequency of acute exacerbation during treatment, and serum inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)] were observed and compared in two groups. Results: After treatment, the FEV1, FVC and FEV1/FVC in experimental group were higher than those in control group (P<0.05). After treatment, the PaCO2 in experimental group was lower than that in control group, while the PaO2 and SaO2 in experimental group were higher than those in control group (P<0.05). After treatment, 6MWD in experimental group was higher than that in control group, while the CAT scores and frequency of acute exacerbation during treatment in experimental group were lower than those in control group (P<0.05). After treatment, serum TNF-α, IL-6 and CRP levels in experimental group were lower than those in control group (P<0.05). Conclusion: Single inhaler triple therapy combine with early pulmonary rehabilitation exercise training for the treatment in patients with moderate to severe COPD, which can enhance the exercise endurance, improve the ability of life activities, reduce the frequency of diseases acute exacerbation during treatment, it can also improve blood gas analysis and pulmonary function indicators, and reduce serum inflammatory factor levels. |
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