| 李 新,李 健,王元国,熊 凯,王 琛,张 鹏.非小细胞肺癌组织KIF2A、KIF2C、KIF20A mRNA表达与临床病理特征和预后的关系[J].,2023,(22):4257-4261 |
| 非小细胞肺癌组织KIF2A、KIF2C、KIF20A mRNA表达与临床病理特征和预后的关系 |
| Relationship between the Expression of KIF2A, KIF2C, and KIF20A mRNA in Non-Small Cell Lung Cancer Tissues and Clinical Pathological Characteristics and Prognosis |
| 投稿时间：2023-06-10 修订日期：2023-06-28 |
| DOI：10.13241/j.cnki.pmb.2023.22.011 |
| 中文关键词: 非小细胞肺癌 KIF2A KIF2C KIF20A 临床病理特征 预后 |
| 英文关键词: Non-small cell lung cancer KIF2A KIF2C KIF20A Clinical pathological characteristics Prognosis |
| 基金项目:天津市自然科学基金（青年）项目（19JCQNJC12000） |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）组织驱动蛋白超家族成员2A（KIF2A）、驱动蛋白超家族成员2C（KIF2C）、驱动蛋白超家族成员20A（KIF20A）信使核糖核酸（mRNA）表达与临床病理特征和预后的关系。方法：选择2016年9月至2019年9月天津医科大学总医院手术切除的NSCLC患者106例，取其癌组织及其对应的癌旁组织，应用荧光定量聚合酶链式反应（RT-qPCR）检测组织中KIF2A、KIF2C、KIF20A mRNA表达，分析其与临床病理特征的关系。应用 Pearson相关性分析NSCLC组织中KIF2A、KIF2C、KIF20A mRNA表达间的关系。随访3年，应用Kaplan-Meier生存曲线分析KIF2A、KIF2C、KIF20A mRNA表达与患者预后关系。结果：NSCLC癌组织中KIF2A、KIF2C、KIF20A mRNA表达水平显著高于癌旁组织（P<0.05）。低分化、淋巴结转移、临床分期Ⅲ A 期NSCLC癌组织中KIF2A、KIF2C、KIF20A mRNA表达水平显著高于中高分化、无淋巴结转移及临床分期I、II期NSCLC癌组织（P<0.05）。Pearson相关分析显示，NSCLC癌组织中KIF2A mRNA表达与KIF2CmRNA、KIF20A mRNA表达呈正相关，KIF2C mRNA表达与KIF20A mRNA表达呈正相关（P<0.05）。Kaplan-Meier法分析显示KIF2A mRNA低表达组、KIF2C mRNA低表达组、KIF20A mRNA低表达组3年生存率分别为（84.78%，86.27%，81.48%）显著高于KIF2A mRNA高表达组、KIF2C mRNA高表达组、KIF20A mRNA高表达组（59.62%，55.32%，59.09%）（P<0.05）。结论：KIF2A、KIF2C、KIF20A mRNA在NSCLC组织中存在高表达，且与低分化、淋巴结转移、临床分期及预后有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of kinesin superfamily 2A (KIF2A), kinesin superfamily 2C (KIF2C), and kinesin superfamily 20A (KIF20A) messenger ribonucleic acid in non-small cell lung cancer (NSCLC) tissues and clinical pathological characteristics and prognosis. Methods: 106 patients with NSCLC who were underwent surgical resection in Tianjin medical university general hospital from September 2016 to September 2019 were selected, the cancerous tissues and its corresponding adjacent tissues were taked, the expression of KIF2A, KIF2C and KIF20A mRNA were detected in tissues by fluorescence quantitative polymerase chain reaction (RT-qPCR), and its relationship with clinical pathological characteristics was analyzed. The relationship between the expression of KIF2A, KIF2C, and KIF20A mRNA in NSCLC tissues was analyzed by Pearson correlation. 3 years followed up, the relationship between the expression of KIF2A, KIF2C, and KIF20A mRNA and patients prognosis was analyzed by the Kaplan-Meier survival curve. Results: The expression levels of KIF2A, KIF2C, and KIF20A mRNA in NSCLC cancer tissues were significantly higher than those in adjacent tissues (P<0.05). The expression levels of KIF2A, KIF2C, and KIF20A mRNA in poorly differentiated, lymph node metastasis, and clinical stage IIIA in NSCLC cancer tissues were significantly higher than those in medium to high differentiated, non lymph node metastasis, and clinical stage I and II in NSCLC cancer tissues (P<0.05). Pearson correlation analysis showed that the expression of KIF2A mRNA in NSCLC cancer tissues was positively correlated with the expression of KIF2C mRNA and KIF20A mRNA, and the expression of KIF2C mRNA was positively correlated with the expression of KIF20A mRNA (P<0.05). Kaplan- Meier method analysis showed that the 3 years survival rates in KIF2A mRNA low expression group, KIF2C mRNA low expression group, and KIF20A mRNA low expression group were (84.78%, 86.27%, 81.48%) significantly higher than those in KIF2A mRNA high expression group, KIF2C mRNA high expression group, and KIF20A mRNA high expression group (59.62%, 55.32%, 59.09%) (P<0.05). Conclusion: KIF2A, KIF2C, and KIF20A mRNA are high expression in NSCLC tissues, and which are related to poorly differentiated, lymph node metastasis, clinical stage and prognosis. |
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