| 何曼曼,王 岱,李智申,高 素,郭芮彤,吴存虎,窦新涛,王玉兰.基于脑肠轴理论探讨健脾化痰方联合针刺治疗卒中后抑郁的随机对照研究[J].,2023,(21):4168-4171 |
| 基于脑肠轴理论探讨健脾化痰方联合针刺治疗卒中后抑郁的随机对照研究 |
| Randomized Controlled Study of the Treatment of Post Stroke Depression with Jianpi Huatan Formula Combined with Acupuncture Based on the Brain Gut Axis Theory |
| 投稿时间：2023-06-01 修订日期：2023-06-24 |
| DOI：10.13241/j.cnki.pmb.2023.21.032 |
| 中文关键词: 脑肠轴理论 健脾化痰方 针刺 卒中后抑郁 疗效 |
| 英文关键词: Brain gut axis theory Jianpi Huatan Formula Acupuncture Post stroke depression Curative effect |
| 基金项目:河北省中医药管理局科研计划项目（2021270） |
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| 中文摘要: |
| 摘要 目的：基于脑肠轴理论探讨健脾化痰方联合针刺治疗卒中后抑郁（PSD）的治疗效果。方法：选取石家庄市中医院2018年4月~2022年5月期间收治的113例PSD患者。按照双色球随机分组法将患者分为对照组（n=56，基于脑肠轴理论，常规治疗联合健脾化痰方治疗）和研究组（n=57，在对照组基础上联合针刺治疗）。对比两组疗效、中医证候积分、美国国立卫生研究院卒中量表（NIHSS)评分、汉密尔顿抑郁量表-17（HAMD-17）评分、日常生活活动能力（ADL）评分、P物质（SP）和神经肽Y（NPY），观察两组治疗期间不良反应发生情况。结果：研究组的临床总有效率高于对照组（P<0.05）。与对照组相比，研究组治疗4周后中医证候积分总分、NIHSS评分、HAMD-17评分和血清SP水平更低，ADL评分和血清NPY水平更高（P<0.05）。两组均未见明显的不良反应发生。结论：基于脑肠轴理论采用健脾化痰方联合针刺治疗PSD患者，可改善患者的临床症状、生活自理能力，同时还可减轻神经缺损状况，调节血清SP、NPY水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the curative effect of Jianpi Huatan Formula combine with acupuncture of post stroke depression (PSD) based on the brain gut axis theory. Methods: 113 PSD patients who were admitted to Shijiazhuang Traditional Chinese Medicine Hospital from April 2018 to May 2022 were selected. The patients were divided into control group (n=56, treated with conventional therapy combined with Jianpi Huatan Formula based on the brain gut axis theory) and study group (n=57, treated with acupuncture on the basis of the control group) according to the method of double color sphere random grouping. The efficacy, traditional chinese medicine syndrome scores, national institute of health stroke scale (NIHSS) scores, hamilton depression scale-17 (HAMD-17) scores, activity of daily living (ADL) scores, substance P (SP) and neuropeptide Y (NPY) were compared between the two groups, and the occurrence of adverse reactions during treatment was observed between the two groups. Results: The total clinical effective rate of the study group was higher than that of the control group(P<0.05). Compared with the control group, the total scores of traditional chinese medicine syndrome scores, NIHSS scores, HAMD-17 scores and serum SP level were lower, the ADL scores and the serum NPY level were higher of the study group at 4 weeks after treatment(P<0.05). There were no significant adverse reactions of the two groups. Conclusion: Using Jianpi Huatan Formula combined with acupuncture to treat PSD patients based on the brain gut axis theory, which can improve patients' clinical symptoms and self-care abilities, alleviate the condition of nerve defects at the same time, and regulate serum SP and NPY levels. |
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