| 康 晶,刘 瞳,唐嘉莹,权 京,赵丽萍.核磁共振T2-star-mapping成像软骨定量分析联合血清COMP、PⅡANP对膝骨关节炎的诊断价值研究[J].,2023,(21):4076-4080 |
| 核磁共振T2-star-mapping成像软骨定量分析联合血清COMP、PⅡANP对膝骨关节炎的诊断价值研究 |
| Diagnostic Value of Quantitative Analysis of Cartilage Using T2-star-mapping Magnetic Resonance Imaging Combined with Serum COMP and PⅡANP in Knee Osteoarthritis |
| 投稿时间：2023-05-06 修订日期：2023-05-30 |
| DOI：10.13241/j.cnki.pmb.2023.21.014 |
| 中文关键词: 膝骨关节炎 核磁共振T2-star-mapping成像 软骨定量分析 骨寡聚基质蛋白 ⅡA型前胶原氨基端肽 诊断价值 |
| 英文关键词: Knee osteoarthritis Magnetic resonance T2-star-mapping imaging Quantitative analysis of cartilage Cartilage oligomeric matrix protein Type IIA procollagen amino terminal peptide Diagnostic value |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2016D01C132） |
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| 中文摘要: |
| 摘要 目的：探讨核磁共振T2-star-mapping成像软骨定量分析联合血清软骨寡聚基质蛋白（COMP）、ⅡA型前胶原氨基端肽（PⅡANP）对膝骨关节炎（KOA）的诊断价值。方法：选择2021年4月至2022年6月本院收治的KOA患者138例为KOA组，同期在本院体检的健康志愿者126例为对照组。采用西门子1.5T核磁共振扫描仪，行膝关节T2-star-mapping成像，获取股骨、胫骨内外侧髁关节面及髌骨软骨面T2*值，采用酶联免疫吸附法（ELISA）检测血清COMP、PⅡANP水平，比较对照组与KOA组、不同病情严重程度KOA患者T2*值及血清COMP、PⅡANP水平，采用受试者工作特征曲线（ROC曲线）分析T2*值联合血清COMP、PⅡANP对KOA的诊断价值。结果：对照组血清COMP水平、股骨内侧T2*值、股骨外侧T2*值、胫骨内侧T2*值、胫骨外侧T2*值、髌骨软骨面T2*值低于KOA组（P＜0.05），血清PⅡANP水平高于KOA组（P＜0.05）。重度组血清COMP水平、股骨内侧T2*值、股骨外侧T2*值、胫骨内侧T2*值、胫骨外侧T2*值、髌骨软骨面T2*值高于中度组，且中度组高于轻度组（P＜0.05）；重度组血清PⅡANP水平低于中度组，且中度组低于轻度组（P＜0.05）。血清COMP水平、血清PⅡANP水平、T2*值、联合检测诊断KOA的ROC曲线下面积分别为0.873、0.843、0.898、0.981。结论：KOA患者血清COMP水平、T2*值升高，血清PⅡANP水平降低，其升高或降低程度与病情严重程度有关，联合检测血清COMP、PⅡANP水平及T2*值对KOA早期诊断价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the diagnostic value of quantitative analysis of cartilage using T2 star mapping magnetic resonance imaging combined with serum cartilage oligomeric matrix protein (COMP) and type IIA procollagen amino terminal peptide (PⅡANP) in knee osteoarthritis (KOA). Methods: 138 KOA patients who were admitted to our hospital from April 2021 to June 2022 were selected as the KOA group, and 126 healthy subjects who underwent physical examination at our hospital were selected as the control group. The Siemens 1.5T magnetic resonance scanner was used to perform T2-star-mapping imaging of the knee joint, and the T2* values of the femoral, tibial, and patellar cartilage surfaces were obtained. The serum levels of COMP and PⅡ ANP were measured using enzyme-linked immunosorbent assay (ELISA), the T2* value and serum COMP, PⅡANP levels between the control group and the KOA group were compared, as well as patients with different severity of KOA. The diagnostic value of T2* value combined with serum COMP and PⅡANP in KOA was analyzed using the receiver operating characteristic curve (ROC curve). Results: The serum COMP levels, medial femur T2* values, lateral femur T2* values, medial tibia T2* values, lateral tibia T2* values, and patellar cartilage surface T2* values in the control group were lower than those in the KOA group (P<0.05), while serum PⅡANP levels were higher than those in the KOA group (P<0.05). The serum COMP level, medial femur T2* value, lateral femur T2* value, medial tibia T2* value, lateral tibia T2* value, and patellar cartilage surface T2* value in the severe group were higher than those in the moderate group, and the moderate group was higher than those in the mild group(P<0.05). The serum PⅡ ANP levels in the severe group was lower than that in the moderate group, and the moderate group was lower than that in the mild group (P<0.05). The serum COMP level, serum PⅡANP level, T2* value, and the area under the ROC curve for combined detection and diagnosis of KOA were 0.873, 0.843, 0.898, and 0.981, respectively. Conclusion: The serum levels of COMP and T2* in KOA patients increase, while the serum levels of PⅡ ANP decrease. The degree of their increase or decrease is related to the severity of the condition. Combined detection of serum levels of COMP, PⅡ ANP, and T2* has high diagnostic value for early diagnosis of KOA. |
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