| 汪敏行,阴鲁鑫,石 叶,陈洪福,褚夫政,高文昌.脑胶质瘤患者血清MBP、LAR、AGR与术后脑损伤和预后的关系研究[J].,2023,(20):3974-3978 |
| 脑胶质瘤患者血清MBP、LAR、AGR与术后脑损伤和预后的关系研究 |
| Study on the Relationship between Serum MBP, LAR, AGR and Postoperative Brain Injury and Prognosis in Patients with Glioma |
| 投稿时间：2023-03-07 修订日期：2023-03-31 |
| DOI：10.13241/j.cnki.pmb.2023.20.035 |
| 中文关键词: 脑胶质瘤 MBP LAR AGR 脑损伤 预后 |
| 英文关键词: Glioma MBP LAR AGR Brain injury Prognosis |
| 基金项目:中国博士后科学基金项目（2015M571821） |
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| 中文摘要: |
| 摘要 目的：探讨脑胶质瘤患者血清髓鞘碱性蛋白（MBP）、乳酸脱氢酶（LDH）与白蛋白（ALB）比值（LAR）、ALB与球蛋白（GLB）比值（AGR）与术后脑损伤和预后的关系研究。方法：选取2017年1月～2019年6月徐州医科大学附属医院神经外科收治的90例接受手术治疗的脑胶质瘤患者，根据术后格拉斯哥昏迷量表（GCS）评分分为轻度脑损伤组51例、中度脑损伤组24例、重度脑损伤组15例，随访3年根据预后情况分为死亡组和存活组。收集患者临床资料，检测术前血清MBP、LAR、AGR。采用Spearman相关性分析脑胶质瘤患者GCS评分与血清MBP、LAR、AGR的相关性，多因素logistic回归分析脑胶质瘤患者死亡的影响因素。结果：轻度、中度、重度脑损伤组血清MBP、LAR依次升高，AGR依次降低（P＜0.05）。Spearman相关性分析显示，脑胶质瘤患者术后GCS评分与血清MBP、LAR呈负相关，与AGR呈正相关（P均＜0.05）。随访3年，90例脑胶质瘤患者死亡率为35.56%（32/90）。多因素logistic回归分析显示，世界卫生组织（WHO）分级Ⅲ级、切除范围不完全、术后GCS评分降低和MBP、LAR升高为脑胶质瘤患者死亡的独立危险因素，AGR升高为其独立保护因素（P＜0.05）。结论：胶质瘤患者血清MBP、LAR、AGR与术后脑损伤和预后不良密切相关，可能成为胶质瘤患者术后脑损伤和预后评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship study between serum myelin basic protein (MBP), lactate dehydrogenase (LDH) to albumin (ALB) ratio (LAR), ALB to globulin (GLB) ratio (AGR) and postoperative brain injury and prognosis in patients with glioma. Methods: 90 cases of patients with glioma who received surgical treatment admitted to Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University from January 2017 to June 2019 were retrospectively selected, and they were divided into mild brain injury group with 51 cases, moderate brain injury group with 24 cases and severe brain injury group with 15 cases according to the score of the Glasgow Coma Scale (GCS) after surgery. After 3 years of follow-up, they were divided into death group and survival group according to the prognosis. Clinical data were collected, and serum MBP, LAR and AGR before surgery were detected. Spearman correlation was used to analyze the correlation between GCS score and serum MBP, LAR and AGR in patients with glioma, and multivariate logistic regression was used to analyze the influencing factors of death in patients with glioma. Results: Serum MBP and LAR in the mild, moderate and severe brain injury groups were increased successively, while AGR was decreased successively (P＜0.05). Spearman correlation analysis showed that postoperative GCS score in patients with glioma was negatively correlated with serum MBP and LAR, and positively correlated with AGR (all P＜0.05). After 3 years of follow-up, the mortality rate of 90 cases of patients with glioma was 35.56% (32/90). Multivariate logistic regression analysis showed that World Health Organization (WHO) grade Ⅲ, incomplete resection range, decreased postoperative GCS score and elevated MBP and LAR were the independent risk factors for death in patients with glioma, and elevated AGR was the independent protective factor (P＜0.05). Conclusion: Serum MBP, LAR and AGR in patients with glioma are closely related to postoperative brain injury and poor prognosis, which may be used as indicators to evaluate postoperative brain injury and prognosis in patients with glioma. |
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