| 熊 静,赵丹雪,冯晓敏,陈丹丹,杨湘越.血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平与冠心病患者冠状动脉病变严重程度的关系及其预测价值分析[J].,2023,(19):3660-3664 |
| 血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平与冠心病患者冠状动脉病变严重程度的关系及其预测价值分析 |
| Relationship between Serum ApoB/ApoA1 Ratio, TG/HDL-C Ratio, LDH and ALP Levels and Severity of Coronary Artery Lesions in Patients with Coronary Heart Disease and Their Predictive Value Analysis |
| 投稿时间：2023-02-15 修订日期：2023-03-11 |
| DOI：10.13241/j.cnki.pmb.2023.19.012 |
| 中文关键词: 冠心病 ApoB/ApoA1比值 TG/HDL-C比值 乳酸脱氢酶 碱性磷酸酶 严重程度 预测价值 |
| 英文关键词: Coronary heart disease ApoB/ApoA1 ratio TG/HDL-C ratio Lactate dehydrogenase Alkaline phosphatase Severity Predictive value |
| 基金项目:福建省科技计划项目（2018Y0068） |
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| 中文摘要: |
| 摘要 目的：探讨血清载脂蛋白B（ApoB）/载脂蛋白A1（ApoA1）比值、三酰甘油（TG）/高密度脂蛋白胆固醇（HDL-C）比值、乳酸脱氢酶（LDH）及碱性磷酸酶（ALP）水平与冠心病（CHD）患者冠状动脉病变严重程度的关系及其预测价值。方法：选取2019年1月-2021年12月因胸痛来我院检查并收治的185例患者，根据检查结果是否为CHD分为CHD组（120例）和对照组（65例），根据Gensini评分将CHD组分为轻度狭窄亚组36例、中度狭窄亚组55例、重度狭窄亚组29例。入院后检测血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平。采用Spearman相关系数分析CHD患者血清ApoB/ApoA1比值、TG/HDL-C比值、LDH、ALP水平与Gensini评分的相关性，采用多因素Logistic回归分析CHD的影响因素；受试者工作特征（ROC）曲线分析血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平对CHD的预测价值。结果：与对照组比较，CHD组吸烟、饮酒、高血压、糖尿病比例和血清总胆固醇（TC）、TG、低密度脂蛋白胆固醇（LDL-C）、ApoB、ApoB/ApoA1比值、TG/HDL-C比值、LDH、ALP水平升高，HDL-C、ApoA1水平降低（P＜0.05）。轻度、中度、重度狭窄亚组血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平依次升高（P＜0.05）。CHD患者血清ApoB/ApoA1比值、TG/HDL-C比值、LDH、ALP水平与Gensini评分呈正相关（P均＜0.001）。多因素Logistic回归分析显示，高血压、血清ApoB/ApoA1比值、TG/HDL-C比值、LDH、ALP水平升高为CHD的独立危险因素（P＜0.05）。ROC曲线分析显示，血清ApoB/ApoA1比值、TG/HDL-C比值、LDH及ALP水平联合预测CHD的曲线下面积大于单独预测（P＜0.05）。结论：血清ApoB/ApoA1比值、TG/HDL-C比值、LDH、ALP水平与CHD患者冠状动脉病变严重程度有关，且联合预测CHD的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio, triacylglycerol (TG)/high density lipoprotein cholesterol (HDL-C) ratio, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels and the severity of coronary artery disease in patients with coronary heart disease (CHD) and their predictive value. Methods: 185 patients who were admitted to our hospital for chest pain from January 2019 to December 2021 were selected, and they were divided into CHD group (120 cases) and control group (65 cases) according to the examination results. According to Gensini score, the CHD group was divided into mild stenosis subgroup with 36 cases, moderate stenosis subgroup with 55 cases and severe stenosis subgroup with 29 cases. Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were measured after admission. Spearman correlation coefficient was used to analyze the correlation between serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH, ALP level and Gensini score in patients with CHD, and multivariate logistic regression was used to analyze the influencing factors of CHD. The predictive value of serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels on CHD was analyzed by the ROC curve. Results: Compared with the control group, the proportion of smoking, alcohol consumption, hypertension, diabetes mellitus and serum total cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C), ApoB, ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in the CHD group were increased, the HDL-C and ApoA1 levels were decreased (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels in mild, moderate and severe stenosis groups were increased successively (P＜0.05). Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels were positively correlated with Gensini score in patients with CHD (all P＜0.001). Multivariate Logistic regression analysis showed that hypertension, serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels increased were independent risk factors for CHD (P＜0.05). ROC curve analysis showed that the combined prediction of ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels of CHD was larger than alone (P＜0.05). Conclusion: Serum ApoB/ApoA1 ratio, TG/HDL-C ratio, LDH and ALP levels are related to the severity of coronary artery disease in CHD patients, and the value of joint prediction of CHD is high. |
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