| 闵 彬,郭春霞,郭 莉,张君毅,常 樱.公英益胃汤联合四联疗法对慢性胃炎的治疗效果及对幽门螺旋杆菌感染的影响[J].,2023,(18):3524-3527 |
| 公英益胃汤联合四联疗法对慢性胃炎的治疗效果及对幽门螺旋杆菌感染的影响 |
| Effect of Gongying Yiwei Decoction combined with Quadruple Therapy on Chronic Gastritis and Helicobacter Pylori Infection |
| 投稿时间：2023-03-10 修订日期：2023-04-05 |
| DOI：10.13241/j.cnki.pmb.2023.18.024 |
| 中文关键词: 慢性胃炎 幽门螺旋杆菌感染 公英益胃汤 四联疗法 |
| 英文关键词: Chronic gastritis Helicobacter pylori infection Gongying Yiwei Decoction Quadruple therapy |
| 基金项目:陕西省自然科学基础研究计划项目（2021JM-320） |
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| 中文摘要: |
| 摘要 目的：分析感染幽门螺旋杆菌（Hp）的慢性胃炎患者在接受治疗时应用公英益胃汤+四联疗法后对疗效的影响。方法：随机将80例我院诊治的Hp阳性的慢性胃炎患者分为对照组与实验组，每组40例，对比两组患者的治疗效果、两组患者治疗前后症状评分、两组患者症状缓解时间、Hp清除率及复发率、两组患者不良反应发生率。结果：实验组患者的治疗总有效率为97.50 %，对照组患者的治疗总有效率为77.50%，实验组治疗有效率较对照组高（P＜0.05）；治疗前两组患者的上腹疼痛、反酸、嗳气、食后胀满各项症状积分差异无统计学意义（P＞0.05），治疗后两组患者的上腹疼痛、反酸、嗳气、食后胀满各项症状积分均降低，并且治疗后实验组患者以上症状评分均低于对照组治疗后（P＜0.05）；实验组患者腹部隐痛、食欲不佳、反酸缓解时间均较对照组短（P＜0.05）；两组不良反应发生率无差异（P＞0.05）；实验组患者的HP根除率高于对照组，复发率低于对照组（P＜0.05）。结论：公英益胃汤+四联疗法对于减轻Hp感染的慢性胃炎患者临床症状，促进其病情在短时间内得到缓解有着显著的疗效，同时这一治疗方案也能够有效清除患者体内的幽门螺旋杆菌，避免疾病的反复发作，降低疾病复发率，且不良反应较少，能够保证患者的用药安全。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of Gongying Yiwei Decoction + quadruple therapy on the curative effect of chronic gastritis patients infected with Helicobacter pylori (HP). Methods: 80 patients with HP positive chronic gastritis diagnosed and treated in our hospital were randomly divided into a matched group and an experimental group, with 40 patients in each group. The treatment effects, symptom scores before and after treatment, symptom relief time, HP clearance rate and recurrence rate, and adverse reaction rate of the two groups were compared. Results: The total effective rate of treatment in the experimental group was 97.50%, and that in the matched group was 77.50%. The effective rate of treatment in the experimental group was higher than that in the matched group (P<0.05); There was no significant difference in the scores of symptoms of epigastric pain, acid reflux, belching and postprandial fullness between the two groups before treatment (P>0.05). After treatment, the scores of symptoms of epigastric pain, acid reflux, belching and postprandial fullness in the two groups decreased, and the scores of the above symptoms in the experimental group were lower than those in the matched group after treatment (P<0.05); The relief time of abdominal dull pain, poor appetite and acid reflux in the experimental group was shorter than that in the matched group (P<0.05); There was no difference between the two groups (P>0.05); The HP eradication rate of the patients in the experimental group was higher than that of the matched group, and the recurrence rate was lower than that of the matched group (P<0.05). Conclusion: Gongying Yiwei Decoction + quadruple therapy has a significant effect on alleviating the clinical symptoms of chronic gastritis patients infected with HP and promoting the remission of their conditions in a short time. At the same time, this treatment scheme can also effectively clear Helicobacter pylori in patients, avoid repeated attacks of the disease, reduce the recurrence rate of the disease, and have fewer adverse reactions, which can ensure the safety of drug use for patients. |
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