| 马云瑶,薛 超,刘海涛,杨 潇,史 卓,胡 艳.弥散加权成像联合血清CEA、TFF1、sE-cadherin对乳腺良恶性肿块的鉴别价值研究[J].,2023,(17):3273-3277 |
| 弥散加权成像联合血清CEA、TFF1、sE-cadherin对乳腺良恶性肿块的鉴别价值研究 |
| Study on the Value of Diffusion-weighted Imaging Combined with Serum CEA, TFF1, and sE-cadherin in Differentiating Benign and Malignant Breast Masses |
| 投稿时间：2023-03-21 修订日期：2023-04-18 |
| DOI：10.13241/j.cnki.pmb.2023.17.014 |
| 中文关键词: 弥散加权成像 癌胚抗原 三叶因子1 可溶性上皮钙黏蛋白 乳腺肿块 鉴别价值 |
| 英文关键词: Diffusion-weighted imaging Carcinoembryonic antigen Trefoil factor 1 Soluble epithelial cadherin Breast masss Identifying value |
| 基金项目:中国癌症基金会北京希望马拉松专项基金项目（LC2017B22） |
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| 中文摘要: |
| 摘要 目的：探讨弥散加权成像（DWI）联合血清癌胚抗原（CEA）、三叶因子1（TFF1）、可溶性上皮钙黏蛋白（sE-cadherin）对乳腺良恶性肿块的鉴别价值。方法：选择2020年1月至2022年1月中国中医科学院广安门医院收治的81例乳腺肿块患者，所有患者均接受DWI检查并记录标准化表观弥散系数（ADC），检测血清CEA、TFF1、sE-cadherin水平。以手术病理或空芯针活检病理学结果为准，分析ADC联合血清CEA、TFF1、sE-cadherin鉴别乳腺良恶性肿块的价值。结果：经病理学检查确诊恶性乳腺肿块29例（恶性组），良性乳腺肿块52例（良性组）。恶性乳腺肿块T1WI低信号影或等信号影，T2WI 呈高信号影或混杂信号，DWI呈高信号影。恶性组ADC值低于良性组（P＜0.05），血清CEA、TFF1、sE-cadherin水平高于良性组（P＜0.05）。联合ADC值和血清CEA、TFF1、sE-cadherin鉴别乳腺肿块良恶性的曲线下面积为0.869，高于单独指标的0.677、0.681、0.654、0.581。结论：乳腺恶性肿块DWI图像呈高信号影，ADC值降低。乳腺恶性肿块患者血清CEA、TFF1、sE-cadherin水平增高，联合ADC值和血清CEA、TFF1、sE-cadherin可有效鉴别乳腺肿块性质。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of diffusion-weighted imaging (DWI) combined with serum carcinoembryonic antigen (CEA), trefoil factor 1 (TFF1) and soluble epithelial cadherin (sE-cadherin) in differentiating benign and malignant breast masses. Methods: 81 patients with breast mass who were admitted to Guang 'anmen Hospital of Chinese Academy of Traditional Chinese Medicine from January 2020 to January 2022 were selected. All patients underwent DWI examination and standardized apparent diffusion coefficient (ADC) was recorded, the serum CEA, TFF1 and sE-cadherin levels were detected. The value of ADC combined with serum CEA, TFF1 and sE-cadherin in differentiating benign and malignant breast masses was analyzed based on the results of surgical pathology or hollow needle biopsy. Results: Pathological examination confirmed malignant breast mass with 29 cases (malignant group), and benign breast mass with 52 cases (benign group). Malignant breast mass showed low or equal signal shadow on T1WI, high or mixed signal on T2WI, and high signal shadow on DWI. The ADC value in the malignant group was lower than that in the benign group (P＜0.05), and the serum CEA, TFF1 and sE-cadherin levels were higher than those in the benign group (P＜0.05). The area under the curve of combined ADC value and serum CEA, TFF1 and sE-cadherin was 0.869, which was higher than 0.677, 0.681, 0.654 and 0.581 of single index. Conclusion: The DWI images of malignant breast masses show high signal shadow, and decrease of ADC value. Serum CEA, TFF1 and sE-cadherin levels increase in patients with malignant breast masses. The combination of ADC value and serum CEA, TFF1 and sE-cadherin can effectively identify the nature of breast masses. |
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