| 郭 明,周 珊,白 露,黄瑶楠,刘家云.普洱茶茶褐素对代谢综合征大鼠TGF-β/Smads通路、氧化应激反应及肝组织能量代谢变化的影响[J].,2023,(17):3211-3215 |
| 普洱茶茶褐素对代谢综合征大鼠TGF-β/Smads通路、氧化应激反应及肝组织能量代谢变化的影响 |
| Effects of Pu'er Tea Theophycin on TGF-β/Smads Pathway, Oxidative Stress Response and Energy Metabolism of Liver in Rats with Metabolic Syndrome |
| 投稿时间：2023-04-07 修订日期：2023-04-30 |
| DOI：10.13241/j.cnki.pmb.2023.17.002 |
| 中文关键词: 普洱茶茶褐素 代谢综合征 TGF-β/Smads通路 氧化应激 肝组织能量代谢 |
| 英文关键词: Pu 'er tea theophylcin Metabolic syndrome TGF-β/Smads pathway Oxidative stress Liver tissue energy metabolism |
| 基金项目:陕西省自然科学基础研究计划项目（2020JQ-459） |
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| 中文摘要: |
| 摘要 目的：探讨普洱茶茶褐素对代谢综合征大鼠TGF-β/Smads通路、氧化应激反应及肝组织能量代谢变化的影响。方法：60只SPF级SD大鼠，随机分为模型组、对照组、普洱茶茶褐素高、中、低剂量，模型组、高、中、低剂量组大鼠给予高糖、高脂、高盐进行代谢综合征造模，对照组大鼠给予普通饲料喂养，造模同时，普洱茶茶褐素低剂量组给予0.281 g/kg?bw普洱茶茶褐素，中剂量组给予0.562 g/kg?bw，高剂量组给予1.124 g/kg?bw，对照组每日灌胃给予等量的蒸馏水。对比普洱茶茶褐素对大鼠的体重、生化指标的影响，对比5组大鼠心脏组织的TNF-β1蛋白水平、氧化应激反应指标、肝组织能量代谢指标。结果：与对照相比，低、中、高剂量组、模型组的收缩压、体重、低密度脂蛋白、总胆固醇、甘油三酯、空腹血糖、空腹胰岛素、胰岛素抵抗指数、TNF-β1、Smads、髓过氧化物酶、丙二醛明显较高，与低剂量组相比，中、高剂量组、模型组明显较高，与中剂量组相比，高剂量组、模型组明显较高，与高剂量组相比，模型组较高。与对照组相比，低、中、高剂量组、模型组的高密度脂蛋白、谷胱甘肽过氧化物酶、总抗氧化能力、超氧化物酶、ATP、ADP、AMP明显较低，与低剂量组相比，中、高剂量组、模型组较低；与低剂量组相比，高剂量组、模型组较低；与高剂量相比，模型组较低，P<0.05。结论：普洱茶茶褐素可通过代谢综合征大鼠TGF-β/Smads通路，改善氧化应激反应及肝组织能量代谢。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Pu 'er tea theophycin on TGF-β/Smads pathway, oxidative stress response and energy metabolism of liver in rats with metabolic syndrome. Methods: 60 SPF SD rats were randomly divided into model group, control group, high, medium and low doses of Pu 'er tea theophycin; rats in model group, high, medium and low dose groups were fed with high sugar, high fat and high salt for metabolic syndrome modeling; rats in control group were fed with common diet while modeling. The low-dose group was given 0.281 g/kg?bw theophylcin of Pu 'er tea, the medium-dose group was given 0.562 g/kg?bw, the high-dose group was given 1.124 g/kg?bw, and the control group was given the same amount of distilled water by intragastric administration daily.The effects of Pu-erh tea theophycin on body weight and biochemical indexes of rats were compared. The levels of TNF-β1 protein in heart tissue, oxidative stress response index and energy metabolism index in liver tissue of 5 groups of rats were compared. Results: Compared with the control group, systolic blood pressure, body weight, low density lipoprotein, total cholesterol, triglyceride, fasting blood glucose, fasting insulin, insulin resistance index, TNF-β1, Smads, myeloperoxidase and malondialdehyde in low, medium and high dose groups and model group were higher, while compared with low dose group, medium and high dose groups and model group were higher. Compared with the medium-dose group, the high-dose group and the model group were higher, and the model group was higher than the high-dose group. Compared with the control group, the high density lipoprotein, glutathione peroxidase, total antioxidant capacity, superoxidase, ATP, ADP and AMP in low, medium and high dose groups and model group were lower, while compared with low dose group, medium and high dose groups and model group were lower. Compared with the low dose group, the high dose group and the model group were lower. Compared with the high dose, the model group was lower, P<0.05. Conclusion: Theophycin of Pu 'er tea can improve oxidative stress response and liver energy metabolism through TGF-β/Smads pathway in rats with metabolic syndrome. |
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