| 靳 丹,罗世杰,马艳芳,王玉君,郭靖宁.补阳还五汤联合西药治疗小儿过敏性紫癜性肾炎的疗效及对机体血管内皮功能的影响研究[J].,2023,(16):3083-3087 |
| 补阳还五汤联合西药治疗小儿过敏性紫癜性肾炎的疗效及对机体血管内皮功能的影响研究 |
| Effect of Buyang Huanwu Decoction and Western Medicine on Allergic Purpura Nephritis in Children and Its Effect on Vascular Endothelial Function |
| 投稿时间：2023-01-12 修订日期：2023-02-08 |
| DOI：10.13241/j.cnki.pmb.2023.16.016 |
| 中文关键词: 补阳还五汤 过敏性紫癜性肾炎 血管内皮功能 肾功能 凝血功能 炎症因子 |
| 英文关键词: Buyang Huanwu Decoction Henoch Schonlein purpura nephritis Vascular endothelial function Renal function Coagulation function Inflammatory factor |
| 基金项目:陕西省名中医罗世杰工作室项目（陕卫中医发〔2018〕95号） |
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| 中文摘要: |
| 摘要 目的：探讨补阳还五汤联合西药治疗小儿过敏性紫癜性肾炎的疗效及对机体血管内皮功能的影响。方法：选取我院2019年1月到2022年12月收治的86例过敏性紫癜性肾炎患儿作为研究对象，分为观察组与对照组，每组43例。对照组患儿采取常规西药治疗，观察组患儿采取补阳还五汤联合西药常规治疗，对比两组患儿临床疗效，并对比治疗前与治疗3个月后患儿的肾功能变化、炎症因子水平变化、血管内皮功能与凝血功能变化。结果：观察组治疗总有效率较对照组高（P＜0.05）；两组患儿治疗前明胶酶相关脂质运载蛋白（NGAL）、血肌酐（SCr）、血尿素氮（BUN）对比无差异（P＞0.05），治疗后两组患儿NGAL、SCr、BUN水平均升高，观察组较对照组高（P＜0.05）；两组患儿治疗前转化生长因子-β1（TGF-β1）、白细胞介素-18（IL-18）和白细胞介素-6（IL-6）相关炎症因子水平对比无差异（P＞0.05），治疗后观察组患儿TGF-β1、IL-18和IL-6相关炎症因子水平低于对照组（P＜0.05）；两组患儿治疗前D-二聚体、纤维蛋白原（FIB）、一氧化氮（NO）和内皮素-1（ET-1）水平对比无差异（P＞0.05），治疗后观察组患儿D-二聚体、FIB和ET-1水平均降低，且观察组低于对照组，NO水平升高，观察组较对照组高（P＜0.05）。结论：补阳还五汤联合西药治疗小儿过敏性紫癜性肾炎临床疗效显著，能够改善患儿肾功能，降低机体炎症反应，提升凝血功能的同时，进一步改善患儿血管内皮功能，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the therapeutic effect of Buyang Huanwu Decoction (BHD) combined with western medicine on children with allergic purpura nephritis (HSPN) and its effect on vascular endothelial function. Methods: 86 children with Henoch Schonlein purpura nephritis admitted to our hospital from January 2019 to December 2022 were selected as the research objects, and they were divided into the observation group and the matched groupp, with 43 cases in each group. The children in the matched groupp were treated with conventional western medicine, and the children in the observation group were treated with Buyang Huanwu Decoction combined with conventional western medicine. The clinical effects of the two groups of children were compared, and the changes in renal function, inflammatory factor levels, vascular endothelial function and blood coagulation function before and after treatment for 3 months were compared. Results: The total effective rate of the observation group was higher than that of the matched groupp (P<0.05); Before treatment, there was no difference between the two groups in the levels of gelatinase related lipid carrier protein (NGAL), serum creatinine (SCR) and blood urea nitrogen (BUN) (P>0.05). After treatment, the levels of NGAL, SCR and BUN in the two groups were higher than those in the matched groupp (P<0.05); There was no difference in the levels of transforming growth factor- β 1 (TGF- β 1), interleukin-18 (IL-18) and IL-6 between the two groups (P>0.05). The levels of TGF- β 1, IL-18 and IL-6 related inflammatory factors in the post-treatment observation group were lower than those in the matched groupp(P<0.05); There was no difference in the levels of D-dimer, fibrinogen (FIB), nitric oxide (NO) and endothelin-1 (ET-1) between the two groups before treatment (P>0.05). After treatment, the levels of D-dimer, FIB and ET-1 in the observation group were lower than those in the matched groupp, and the level of NO in the observation group was higher than that in the matched groupp (P<0.05). Conclusion: Buyang Huanwu Decoction combined with western medicine has a significant clinical effect on children with Henoch Schonlein purpura nephritis. It can improve the renal function of children, reduce the inflammatory reaction of the body, enhance the blood coagulation function, and further improve the vascular endothelial function of children. It is worthy of clinical application and promotion. |
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