| 李明伟,刘 玉,岳迎宾,李丹露,赵 莉,严 媚.淋巴细胞及其亚群、NK细胞与儿童原发性免疫性血小板减少症复发的相关性研究[J].,2023,(16):3054-3057 |
| 淋巴细胞及其亚群、NK细胞与儿童原发性免疫性血小板减少症复发的相关性研究 |
| Study on the Correlation between Iymphocytes and Its Subgroups, NK cells and the Recurrence of Childhood Primary Immune Thrombocytopenia |
| 投稿时间：2023-01-07 修订日期：2023-01-30 |
| DOI：10.13241/j.cnki.pmb.2023.16.010 |
| 中文关键词: 儿童原发性免疫性血小板减少症 淋巴细胞及其亚群 NK细胞 复发 |
| 英文关键词: Childhood primary immune thrombocytopenia Lymphocytes and their subgroups NK cells Relapse |
| 基金项目:2021年国家自然科学基金地区项目（82160031） |
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| 中文摘要: |
| 摘要 目的：为探讨淋巴细胞及其亚群、NK细胞与儿童原发性免疫性血小板减少症（ITP）复发的关系，评估其预测价值，为临床评估患者预后提供理论支持。方法：回顾性分析2017年12月-2021年12月于新疆医科大学第一附属医院儿科中心初发首诊为原发性免疫性血小板减少症的165例患儿，根据是否复发分为复发组与无复发组，评估ITP复发的影响因素，利用ROC曲线评估淋巴细胞计数绝对值对儿童ITP复发的预测价值，运用Kaplan-Meier法绘制与淋巴细胞计数绝对值相关的儿童ITP无复发生存曲线。结果：共纳入165名ITP患儿，复发率24.8%。淋巴细胞计数绝对值对儿童ITP无复发的ROC曲线下面积为0.704，95%CI为0.613-0.795（P＜0.05），最佳截断值为3.21×109/L。儿童ITP是否复发与年龄、淋巴细胞计数、出血评分、ESR有关，两组比较差异有统计学意义（P<0.05）。儿童ITP是否复发与CD3+CD19-细胞计数、CD3+CD4+细胞计数、CD3+CD8+细胞计数、CD4+/CD8+细胞比例、NK细胞计数有关，两组比较差异有统计学意义（P<0.05）。结论：淋巴细胞计数绝对值可作为评估儿童ITP复发的预测指标，儿童ITP复发与初始T淋巴细胞亚群、NK细胞计数具有一定相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between lymphocytes and their subgroups, NK cells and the recurrence of primary immunological thrombocytopenia in children, evaluate its predictive value, and provide theoretical support for clinical evaluation of patient prognosis. Methods: A retrospective analysis of 165 children with immunological thrombocytopenia who were first diagnosed with immunological thrombocytopenia in the Department of Pediatrics of the First Affiliated Hospital of Xinjiang Medical University from December 2017 to December 2021 were divided into recurrence group and non-recurrence group according to whether they recurred To evaluate the influencing factors of ITP recurrence, use ROC curve to assess the predictive value of the absolute value of lymphocyte count for children's ITP recurrence, and use Kaplan-Meier method to draw the recurrence-free survival curve of children's ITP related to the absolute value of lymphocyte count. Results: A total of 165 children with ITP were enrolled, and the recurrence rate was 24.8%. The area under the ROC curve of the absolute value of lymphocyte count for children with ITP without recurrence was 0.704, 95% CI was 0.613-0.795, P＜0.05, and the best cutoff value was 3.21×109/L. The recurrence of ITP in children is related to age, lymphocyte count, bleeding score, and ESR. The difference between the two groups was statistically significant(P<0.05). The recurrence of ITP in children was related to CD3+CD19- cell count, CD3+CD4+cell count, CD3+CD8+ cell count, CD4+CD8+ cell ratio, and NK cell count. The difference between the two groups was statistically significant (P<0.05). Conclusion: The absolute value of lymphocyte count can be used as a predictive indicator to assess the recurrence of ITP in children. The recurrence of ITP in children has a certain correlation with the initial T lymphocyte subsets and NK cell count. |
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