| 郑 洋,范存愈,卢丽君,雷 俊,田 辉,丁 念,童亚男.清气化痰汤联合穴位贴敷治疗AECOPD痰热壅肺证的疗效及对血清MMP-2、MMP-9、MMP-12的影响[J].,2023,(15):2956-2959 |
| 清气化痰汤联合穴位贴敷治疗AECOPD痰热壅肺证的疗效及对血清MMP-2、MMP-9、MMP-12的影响 |
| Efficacy of Qingqi Huatan Tang Combine with Acupoint Application of AECOPD with Syndrome of Phlegm-Heat Obstructing Lung and its Impact of Serum MMP-2, MMP-9, and MMP-12 |
| 投稿时间：2023-03-18 修订日期：2023-04-12 |
| DOI：10.13241/j.cnki.pmb.2023.15.030 |
| 中文关键词: 清气化痰汤 穴位贴敷 慢性阻塞性肺疾病急性加重期 痰热壅肺证 疗效 MMP-2 MMP-9 MMP-12 |
| 英文关键词: Qingqi Huatan Tang Acupoint application Acute exacerbation of chronic obstructive pulmonary disease Syndrome of phlegm-heat obstructing lung Efficacy MMP-2 MMP-9 MMP-12 |
| 基金项目:湖北省自然科学基金重点项目（2019CFB633） |
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| 摘要 目的：探讨清气化痰汤联合穴位贴敷治疗慢性阻塞性肺疾病急性加重期（AECOPD）痰热壅肺证的疗效及对血清基质金属蛋白酶（MMP）-2、MMP-9、MMP-12的影响。方法：选取武汉市中医医院2020年8月~2022年8月期间收治的116例AECOPD 痰热壅肺证患者，按照随机数表法分成对照组（n=58，西医常规治疗联合穴位贴敷治疗）和实验组（n=58，对照组基础上联合清气化痰汤治疗）。对比两组中医证候积分、慢性阻塞性肺疾病评估测试问卷（CAT）评分、炎症因子指标[白细胞介素（IL）-6、IL-8、降钙素原（PCT）]、肺功能指标[第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC]、血清MMP-2、MMP-9、MMP-12水平。结果：两组治疗后发热、咳嗽或喘息气急、大便干结、口渴喜冷饮、痰多色黄或白黏、CAT评分下降，且实验组低于对照组（P<0.05）。两组治疗后FEV1、FVC、FEV1/FVC升高，且实验组高于对照组（P<0.05）。两组治疗后IL-6、IL-8、PCT下降，且实验组低于对照组（P<0.05）。两组治疗后血清MMP-2、MMP-9、MMP-12下降，且实验组低于对照组（P<0.05）。结论：清气化痰汤联合穴位贴敷治疗AECOPD痰热壅肺证，可改善患者的肺功能，降低炎症因子和血清MMP-2、MMP-9、MMP-12水平，进一步改善患者的临床症状。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of Qingqi Huatan Tang combine with acupoint application of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with syndrome of phlegm-heat obstructing lung and its impact of serum matrix metalloproteinase (MMP) -2, MMP-9 and MMP-12. Methods: 116 AECOPD patients with syndrome of phlegm-heat obstructing lung who were admitted to Wuhan Traditional Chinese Medicine Hospital from August 2020 to August 2022 were selected, and they divide into control group (n=58, routine Western medicine treatment combined with acupoint application treatment) and experimental group (n=58, combined with Qingqi Huatan Tang treatment on the basis of the control group) according to the random number table method. The Traditional Chinese Medicine syndrome scores, COPD assessment test (CAT), inflammatory factor indexes [interleukin (IL) -6, IL-8, procalcitonin (PCT)], lung function indexes [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC], and the serum levels of MMP-2, MMP-9, MMP-12 were compared between the two groups. Results: After treatment, fever, cough or wheezing, shortness of breath, dry stools, thirst, preference for cold drinks, and phlegm with multiple colors of yellow or white sticky, and CAT scores decreased of the two groups, and the experimental group were lower than those of the control group (P<0.05). After treatment, FEV1, FVC, and FEV1/FVC increased of the two groups, and the experimental group were higher than those of the control group (P<0.05). After treatment, IL-6, IL-8 and PCT decreased of the two groups, and the experimental group were lower than those of the control group (P<0.05). After treatment, serum levels of MMP-2, MMP-9, and MMP-12 decreased of the two groups, and the experimental group were lower than those of the control group (P<0.05). Conclusion: Qingqi Huatan Tang combine with acupoint application for the treatment of AECOPD with syndrome of phlegm-heat obstructing lung, which can improve the patient's lung function, reduce inflammatory factors and serum levels of MMP-2, MMP-9, and MMP-12, and further improve the patient's clinical symptoms. |
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