| 张淑霞,卫平存,王 刚,陈世琴,吴 凡.鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎的治疗效果及对患者嗅觉功能和鼻黏膜形态的影响[J].,2023,(15):2894-2898 |
| 鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎的治疗效果及对患者嗅觉功能和鼻黏膜形态的影响 |
| Effects of Prednisolone Medloratadine on Chronic Sinusitis and Olfactory Function and Nasal Mucosa morphology |
| 投稿时间：2023-01-12 修订日期：2023-02-10 |
| DOI：10.13241/j.cnki.pmb.2023.15.018 |
| 中文关键词: 鼻内镜 枸地氯雷他定 慢性鼻窦炎 嗅觉功能 鼻黏膜形态 |
| 英文关键词: Nasal endoscopy Lydesloratadine Chronic sinusitis Olfactory function Morphology of nasal mucosa |
| 基金项目:安徽省中医药管理局安徽省中西医结合重大疑难疾病科技攻关项目（2021zdynjb10） |
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| 中文摘要: |
| 摘要 目的：探讨鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎的治疗效果及对患者嗅觉功能和鼻黏膜形态的影响。方法：选取我院2019年1月到2022年12月收治的80例慢性鼻窦炎患者作为研究对象，分为观察组与对照组，各40例。对照组患者采取单纯鼻内镜手术治疗，观察组患者在术前应用枸地氯雷他定治疗1个月后再行鼻内镜手术，对比两组患者的临床治疗效果，治疗前后炎症因子水平，内镜下鼻粘膜形态量化评分，嗅觉功能与糖精试验时间。结果：两组患者治疗总有效率对比无差异（P＞0.05）；治疗后两组患者IL-6、IL-1、TNF-α相关炎症因子水平均降低，且观察组较对照组低（P＜0.05）；治疗前两组患者鼻漏、结痂、瘢痕、黏膜水肿、息肉、脓性分泌物等情况内镜下鼻粘膜形态量化评分对比无明显差异（P＞0.05），治疗后两组患者鼻漏、结痂、瘢痕、黏膜水肿、息肉、脓性分泌物等情况内镜下鼻粘膜形态量化评分均降低，且观察组较对照组低（P＜0.05）；治疗前两组患者嗅觉识别阈值、糖精试验时间对比无明显差异（P＞0.05），治疗后两组患者嗅觉识别阈值、糖精试验时间均降低，且观察组低于对照组（P＜0.05）。结论：鼻内镜术前应用枸地氯雷他定对慢性鼻窦炎具有显著临床疗效，同时能够降低患者术后炎症因子水平，改善鼻黏膜形态，提升纤毛运动功能与嗅觉功能，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the therapeutic effect of prednisolone on chronic sinusitis and its influence on olfactory function and nasal mucosa morphology in patients with chronic sinusitis. Methods: 80 patients with chronic sinusitis admitted to our hospital from January 2019 to December 2022 were selected as the research objects. All patients were randomly divided into observation group and control group with 40 patients in each group. The patients in the control group were treated with simple endoscopic surgery, while the patients in the observation group were treated with medloratadine before surgery for one month and then underwent endoscopic surgery. The clinical treatment effects, levels of inflammatory factors before and after treatment, quantitative score of endoscopic nasal mucosa morphology, olfactory function and saccharin test time of the two groups were compared. Results: There was no difference in the total effective rate between the two groups (P>0.05); After treatment, IL-6, IL-1 and TNF-α were found in the two groups The levels of inflammatory factors in the observation group were lower than those in the control group (P<0.05); Before treatment, there was no difference between the two groups in the quantitative score of endoscopic nasal mucosa morphology (P>0.05) for patients with rhinorrhea, scab, scar, mucosal edema, polyp, purulent secretion, etc. After treatment, the quantitative score of endoscopic nasal mucosa morphology in patients with rhinorrhea, scab, scar, mucosal edema, polyp, purulent secretion, etc. decreased in the two groups, and the observation group was different with control group (P<0.05); There was no difference in the olfactory recognition threshold and saccharin test time between the two groups before treatment (P>0.05). After treatment, the olfactory recognition threshold and saccharin test time of the two groups decreased, and the observation group were different with control group (P<0.05). Conclusion: Lydesloratadine before endoscopic sinus surgery has a significant clinical effect on chronic sinusitis, and can reduce the level of inflammatory factors in patients after surgery, improve the morphology of nasal mucosa, enhance ciliary motor function and olfactory function, which is worthy of clinical application and promotion. |
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