| 赖煜虹,黄丽云,苏晓平,黄委珍,郑雅茹.龈沟液Chemerin、APN、25(OH)D3与伴2型糖尿病的慢性牙周炎患者牙周指标和Th17/Treg失衡的关系[J].,2023,(15):2883-2887 |
| 龈沟液Chemerin、APN、25(OH)D3与伴2型糖尿病的慢性牙周炎患者牙周指标和Th17/Treg失衡的关系 |
| Relationship between Gingival Crevicular Fluid Chemerin, APN, 25(OH)D3 and Periodontal Indexes and Th17/Treg Imbalance in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2023-01-23 修订日期：2023-02-18 |
| DOI：10.13241/j.cnki.pmb.2023.15.016 |
| 中文关键词: 2型糖尿病 慢性牙周炎 Chemerin APN 25(OH)D3 牙周指标 Th17/Treg失衡 |
| 英文关键词: Type 2 diabetes mellitus Chronic periodontitis Chemerin APN 25(OH)D3 Periodontal indexes Th17/Treg imbalance |
| 基金项目:福建省自然科学基金项目（2016J01575） |
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| 中文摘要: |
| 摘要 目的：探讨龈沟液趋化素（Chemerin）、脂联素（APN）、25-羟维生素D3 [25(OH)D3]与伴2型糖尿病（T2DM）的慢性牙周炎（CP）患者牙周指标和Th17/Treg失衡的关系。方法：选择2021年1月至2022年1月我院口腔科门诊接诊的125例伴T2DM的CP患者，根据CP病情严重程度分为轻度组（42例）、中度组（53例）和重度组（30例）。检测龈沟液中Chemerin、APN、25(OH)D3水平以及外周血中Th17细胞占比、Treg细胞占比，计算Th17/Treg比值，记录出血指数（SBI）、菌斑指数（PLI）、附着丧失（AL）、牙周袋探诊深度（PD）。分析龈沟液中Chemerin、APN、25(OH)D3与牙周指标、外周血Th17/Treg的相关性。结果：重度组龈沟液 Chemerin水平和外周血中Th17细胞占比、Th17/Treg比值、PLI、SBI、AL、PD高于中度组和轻度组（P＜0.05），龈沟液APN、25(OH)D3水平，外周血Treg细胞占比低于中度组和轻度组（P＜0.05）。龈沟液 Chemerin与PLI、SBI、AL、PD、外周血Th17细胞占比、Th17/Treg比值呈正相关（P＜0.05），与Treg细胞占比呈负相关（P＜0.05）；龈沟液APN、25(OH)D3与PLI、SBI、AL、PD、外周血中Th17细胞占比、Th17/Treg比值呈负相关（P＜0.05），与Treg细胞占比呈正相关（P＜0.05）。结论：伴T2DM 的CP患者龈沟液中Chemerin水平增高，APN、25(OH)D3水平降低，且与牙周指标和Th17/Treg失衡有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between gingival crevicular fluid Chemerin, adiponectin (APN), 25-hydroxyvitamin D3 [25(OH)D3] and periodontal indexes and Th17/Treg imbalance in chronic periodontitis (CP) patients with type 2 diabetes mellitus (T2DM). Methods: From January 2021 to January 2022, 125 CP patients with T2DM were selected from the outpatient department of stomatology in our hospital.They were divided into mild group (42 cases), moderate group (53 cases) and severe group (30 cases) according to the severity of CP. The levels of gingival crevicular fluid Chemerin, APN, 25(OH)D3, the percentage of peripheral blood Th17 cells and Treg cells, the Th17/Treg ratio was calculated, and the sulcus bleeding index (SBI), plaque index (PLI), attachment loss (AL) and probing depth of periodontal pocket (PD) were evaluated. The correlation between gingival crevicular fluid Chemerin, APN, 25(OH)D3 and periodontal indexes, peripheral blood Th17/Treg ratio were analyzed. Results: The gingival crevicular fluid Chemerin level, peripheral blood Th17 cell proportion, Th17/Treg ratio, PLI, SBI, AL and PD in the severe group were higher than those in the moderate group and mild group (P＜0.05). The gingival crevicular fluid APN and 25(OH)D3 levels and the peripheral blood Treg cells proportion were lower than those in the moderate group and mild group (P＜0.05). Gingival crevicular fluid Chemerin was positively correlated with PLI, SBI, AL, PD, peripheral blood Th17 cell proportion and Th17/Treg ratio (P＜0.05), and negatively correlated with Treg cell proportion (P＜0.05). The gingival crevicular fluid APN and 25(OH)D3 were negatively correlated with PLI, SBI, AL, PD, peripheral blood Th17 cell proportion and Th17/Treg ratio (P＜0.05), and positively correlated with Treg cell proportion (P＜0.05). Conclusion: The gingival crevicular fluid Chemerin level is increased in CP patients with T2DM, and APN and 25(OH)D3 levels are decreased, which are associated with periodontal indexes and Th17/Treg imbalance. |
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