| 龙训辉,陈 健,王齐国,生 娣,许 玲.血清降钙素原、可溶性血管内皮生长因子受体1及sofa评分与重症感染的相关性及预后预测价值[J].,2023,(15):2878-2882 |
| 血清降钙素原、可溶性血管内皮生长因子受体1及sofa评分与重症感染的相关性及预后预测价值 |
| Correlation of Serum Procalcitonin, Soluble Vascular Endothelial Growth Factor Receptor 1 and Sofa Score with Severe Infection and Prognostic Value |
| 投稿时间：2023-02-06 修订日期：2023-02-28 |
| DOI：10.13241/j.cnki.pmb.2023.15.015 |
| 中文关键词: PCT sFIt-1 序贯器官衰竭评分 重症感染 脓毒症 |
| 英文关键词: PCT sFIt-1 Sequential organ failure score Severe infection Sepsis |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2022D01C808） |
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| 中文摘要: |
| 摘要 目的：探讨血清降钙素原（PCT）、可溶性血管内皮生长因子受体1（sFIt-1）及序贯器官衰竭（sofa）评分与重症感染的相关性及预后预测价值。方法：选取我院2020年1月到2022年12月收治的60例重症感染患者作为研究对象，依照感染严重程度分为脓毒症组（n=25），重度脓毒症组（n=20）与脓毒症休克组（n=15），另选取同期来我院体检的30名健康者作为对照组。对比四组受检者PCT、sFIt-1、sofa评分水平，分析PCT、sFIt-1、sofa与重症感染的相关性。通过对60例重症感染患者的治疗结果情况分为存活组（n=36）和死亡组（n=24），对比两组患者临床一般情况和PCT、sFIt-1、sofa评分水平，并应用；logistic回归分析分析三者对重症感染的预后预测价值。结果：四组受检者PCT、sFIt-1、sofa评分水平对比差异显著，脓毒症休克组高于重度脓毒症组、脓毒症组和对照组（P＜0.05）；Spearman相关分析结果显示：PCT、sFIt-1、sofa评分与重症感染呈正相关（P＜0.05）；存活组与死亡组患者性别、年龄、感染部位、合并冠心病、糖尿病、高血压基础疾病、病原学、重症监护室（Intensive Care Unit，ICU）住院时间对比无差异（P＞0.05），存活组与死亡组患者合并心功能不全、急性生理与慢性健康评分（APACHEⅡ）评分、PCT、sFIt-1、sofa评分对比差异显著（P＜0.05）；logistic回归分析结果表明：PCT、sFIt-1、sofa评分为重度感染预后的独立预测指标（P＜0.05）。结论：PCT、sFIt-1、sofa与重症感染呈正相关，且三者水平越高患者死亡率可能越高，因此需针对PCT、sFIt-1、sofa升高的感染患者改良治疗措施，预防预后不良情况。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between serum procalcitonin (PCT), soluble vascular endothelial growth factor receptor 1 (sFIt-1) and sequential organ failure (sofa) scores and severe infection and the prognostic value. Methods: 60 patients with severe infection admitted to our hospital from January 2020 to December 2022 were selected as the study subjects. According to the severity of infection, they were divided into sepsis group (n=25), severe sepsis group (n=20) and septic shock group (n=15). In addition, 30 healthy people who came to our hospital for physical examination at the same time were selected as the control group. The scores of PCT, sFIT-1 and sofa were compared among the four groups, and the correlation between PCT, sFIT-1 and sofa and severe infection was analyzed. The treatment results of 60 patients with severe infection were divided into survival group (n=36) and death group (n=24). The clinical general conditions and PCT, sFIT-1 and sofa scores of the two groups were compared and applied; Logistic regression analysis was used to analyze the prognostic value of the three factors for severe infection. Results: There were differences in PCT, sFIt-1 and sofa scores among the four groups. The level of septic shock group was significantly higher than that of severe sepsis group, sepsis group and control group (P<0.05); Spearman correlation analysis showed that PCT, sFIt-1 and sofa scores were positively correlated with severe infection (P<0.05); There was no difference between the survival group and the death group in gender, age, infection site, combined coronary heart disease, diabetes, hypertension, etiology, and length of stay in intensive care unit (ICU) (P>0.05). The survival group and the death group were combined with cardiac insufficiency, acute physiology and chronic health score (APACHE Ⅱ), PCT, sFIt-1 There was significant difference in sofa score (P<0.05); The results of logistic regression analysis showed that PCT, sFIt-1 and sofa scores were independent predictors of the prognosis of severe infection (P<0.05). Conclusion: PCT, sFIt-1 and sofa are positively correlated with severe infection, and the higher the level of PCT, sFIt-1 and sofa, the higher the mortality of patients may be. Therefore, it is necessary to improve treatment measures for infected patients with elevated PCT, sFIt-1 and sofa to prevent poor prognosis. |
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