| 刘昌玲,陈耀武,魏晓莹,许 展,李少英,张旭凤.慢性牙周炎患者血清CGRP、PGE2、CCL20与牙周临床指标和Th17/Treg失衡的相关性分析[J].,2023,(14):2745-2749 |
| 慢性牙周炎患者血清CGRP、PGE2、CCL20与牙周临床指标和Th17/Treg失衡的相关性分析 |
| Correlation Analysis of Serum CGRP, PGE2, CCL20 with Periodontal Clinical Indicators and Th17/Treg Imbalance in Patients with Chronic Periodontitis |
| 投稿时间：2022-12-07 修订日期：2022-12-30 |
| DOI：10.13241/j.cnki.pmb.2023.14.028 |
| 中文关键词: 慢性牙周炎 CGRP PGE2 CCL20 牙周临床指标 Th17/Treg失衡 相关性 |
| 英文关键词: Chronic periodontitis CGRP PGE2 CCL20 Periodontal clinical indicators Th17/Treg imbalance Correlation |
| 基金项目:海南省卫生健康行业科研项目（22A200101）；海南省临床医学中心建设项目资助（琼卫医函[2021]75号） |
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| 中文摘要: |
| 摘要 目的：探究慢性牙周炎患者血清降钙素基因相关肽（CGRP）、前列腺素E2（PGE2）、CC趋化因子配体20（CCL20）与牙周临床指标和辅助性T淋巴细胞17/调节性T淋巴细胞（Th17/Treg）失衡的相关性。方法：选取2020年5月-2022年5月海南省妇女儿童医学中心收治的91例慢性牙周炎患者，根据其严重程度分为轻度组（39例）、中度组（36例）、重度组（16例），比较三组血清CGRP、PGE2、CCL20、牙周临床指标[出血指数（BI）、探诊深度（PD）、附着丧失（AL）、菌斑指数（PLI）]、外周血Th17细胞比例、Treg细胞比例、Th17/Treg比值，采用Pearson相关分析血清CGRP、PGE2、CCL20与牙周临床指标和Th17/Treg失衡的相关性。结果：与轻度组比较，中度组、重度组血清CGRP、Treg细胞比例显著降低（P＜0.05），血清PGE2、CCL20、BI、PD、PLI、AL、Th17细胞比例、Th17/Treg比值显著增高（P＜0.05）；与中度组比较，重度组血清CGRP、Treg细胞比例显著降低（P＜0.05），血清PGE2、CCL20、BI、PD、PLI、AL、Th17细胞比例、Th17/Treg比值显著增高（P＜0.05）。相关性结果提示，血清PGE2、CCL20水平与BI、PD、PLI、AL、Th17细胞比例、Th17/Treg比值呈正相关（P＜0.05），与Treg细胞比例呈负相关（P＜0.05）；血清CGRP水平与BI、PD、PLI、AL、Th17细胞比例、Th17/Treg比值呈负相关（P＜0.05），与Treg细胞比例呈正相关（P＜0.05）。结论：慢性牙周炎患者血清CGRP、PGE2、CCL20水平与疾病严重程度、牙周临床指标及Th17/Treg失衡显著相关，血清CGRP、PGE2、CCL20可能通过影响Th17/Treg平衡参与慢性牙周炎的发生和发展。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between serum calcitonin gene related peptide (CGRP), prostaglandin E2 (PGE2), CC chemokine ligand 20 (CCL20) with periodontal clinical indicators and helper T lymphocyte 17/regulatory T lymphocyte (Th17/Treg) imbalance in patients with chronic periodontitis. Methods: 91 patients with chronic periodontitis who were admitted to Hainan Women and Children Medical Center from May 2020 to May 2022 were selected, and they were divided into mild group (39 cases), moderate group (36 cases) and severe group (16 cases) according to their severity. Serum CGRP, PGE2, CCL20, periodontal clinical indicators [bleeding index(BI), probing depth(PD), attachment loss (AL), plaque index (PLI)], peripheral blood Th17 cell ratio, Treg cell ratio, and Th17/Treg ratio were compared in the three groups. Pearson correlation was used to analyze the correlation between serum CGRP, PGE2, CCL20 and periodontal clinical indicators and Th17/Treg imbalance. Results: Compared with the mild group, the serum CGRP and Treg cells proportion in the moderate group and severe group were significantly decreased(P＜0.05), and the serum PGE2, CCL20, BI, PD, PLI, AL, Th17 cells proportion and Th17/Treg ratio were significantly increased(P＜0.05). Compared with the moderate group, the serum CGRP and Treg cells proportion in the severe group were significantly decreased(P＜0.05), while the serum PGE2, CCL20, BI, PD, PLI, AL, Th17 cells proportion and Th17/Treg ratio were significantly increased(P＜0.05). The correlation results showed that serum PGE2 and CCL20 levels were positively correlated with the BI, PD, PLI, AL, Th17 cells proportion and Th17/Treg ratio(P＜0.05), and negatively correlated with the Treg cells proportion(P＜0.05). Serum CGRP level was negatively correlated with BI, PD, PLI, AL, the Th17 cells proportion and Th17/Treg ratio(P＜0.05), and positively correlated with the Treg cells proportion (P＜0.05). Conclusion: Serum CGRP, PGE2 and CCL20 levels in patients with chronic periodontitis are significantly related to the severity of the disease, periodontal clinical indicators and Th17/Treg imbalance. Serum CGRP, PGE2 and CCL20 may participate in the occurrence and development of chronic periodontitis by affecting the Th17/Treg balance. |
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