| 郑媛媛,叶 莎,张倩榕,丁铭格,金爱萍.血清硫氧还蛋白相互作用蛋白、Ⅲ型纤维蛋白结构域结合蛋白5与糖尿病性心肌病的相关性及诊断价值分析[J].,2023,(14):2683-2687 |
| 血清硫氧还蛋白相互作用蛋白、Ⅲ型纤维蛋白结构域结合蛋白5与糖尿病性心肌病的相关性及诊断价值分析 |
| Correlation and Diagnostic Value of Serum Thioredoxin Interacting Protein Type Ⅲ Fibrin Domain Binding Protein 5 with Diabetic Cardiomyopathy |
| 投稿时间：2023-01-27 修订日期：2023-02-23 |
| DOI：10.13241/j.cnki.pmb.2023.14.015 |
| 中文关键词: 糖尿病性心肌病 硫氧还蛋白相互作用蛋白 Ⅲ型纤维蛋白结构域结合蛋白5 |
| 英文关键词: Diabetic cardiomyopathy Thioredoxin interacting protein Type Ⅲ fibrin domain binding protein 5 |
| 基金项目:陕西省重点研发计划项目（2021SF-141） |
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| 中文摘要: |
| 摘要 目的：分析血清硫氧还蛋白相互作用蛋白（TXNIP）、Ⅲ型纤维蛋白结构域结合蛋白5（FNDC5）与糖尿病性心肌病的相关性及诊断价值。方法：选择我院自2019年10月至2022年10月接诊的128例糖尿病患者作为研究对象，其中糖尿病性心肌病53例，作为观察组；左心室二维结构正常75例，作为对照组。检测两组血清TXNIP、FNDC5表达水平，分析糖尿病性心肌病患者血清TXNIP、FNDC5表达水平与左心功能指标的关系，使用多因素Logistic回归分析及ROC曲线分析血清TXNIP、FNDC5对糖尿病性心肌病的诊断价值。结果：观察组血清TXNIP表达水平高于对照组，FNDC5表达水平低于对照组，差异均有统计学意义（P＜0.05）；经Pearson相关性分析，糖尿病性心肌病患者二尖瓣早期血流速度峰值(E)、左侧壁二尖瓣环早期峰值速度均值（e'）、左心室射血分数（LVEF）均与TXNIP呈负相关，与FNDC5呈正相关（P＜0.05）；经多因素Logistic回归分析，血清TXNIP、FNDC5均是糖尿病性心肌病的独立预测因素（P＜0.05）；经ROC曲线分析，血清TXNIP联合FNDC5诊断糖尿病性心肌病的AUC为0.926，明显大于单一指标TXNIP的0.671和FNDC5的0.685，差异均有统计学意义（P＜0.05）。结论：血清TXNIP、FNDC5与糖尿病性心肌病发病及患者左心功能损害程度密切相关，两者联合诊断此病的效能较好，值得临床进一步研究应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the correlation and diagnostic value of serum thioredoxin interacting protein (TXNIP), type Ⅲ fibrin domain binding protein 5(FNDC5) and diabetic cardiomyopathy. Methods: A total of 128 diabetic patients admitted to our hospital from October 2019 to October 2022 were selected as subjects, including 53 diabetic cardiomyopathy as the observation group. The left ventricular two-dimensional structure was normal in 75 cases as matched group. The expression levels of TXNIP and FNDC5 in serum of the two groups were detected, and the relationship between TXNIP and FNDC5 in serum of diabetic cardiomyopathy patient and left heart function indexes was analyzed. The diagnostic value of TXNIP and FNDC5 in diabetic cardiomyopathy was analyzed by multivariate Logistic regression analysis and ROC curve. Results: The TXNIP expression level in the observation group was higher than that in the matched group, and the FNDC5 expression level was lower than that in the matched group, the differences were statistically significant (P<0.05). Through Pearson correlation analysis,the peak value of early mitral valve flow velocity (E), mean value of early mitral ring peak velocity (e') and left ventricular ejection fraction (LVEF) in patients with diabetic cardiomyopathy were negatively correlated with TXNIP (P<0.05) and positively correlated with FNDC5 (P<0.05). By multivariate Logistic regression analysis, TXNIP and FNDC5 were independent predictors of diabetic cardiomyopathy(P<0.05). According to ROC curve analysis, the AUC of TXNIP combined with FNDC5 in the diagnosis of diabetic cardiomyopathy was 0.926, which was significantly greater than that of TXNIP (0.671) and FNDC5 (0.685), with statistical significance(P<0.05). Conclusion: Serum TXNIP and FNDC5 are closely related to the onset of diabetic cardiomyopathy and the degree of left heart function impairment. The combination of TXnip and FNDC5 is effective in the diagnosis of diabetic cardiomyopathy, which is worthy of further clinical study and application. |
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