| 马志飞,陈 文,张爱平,沈晓康,缪 劲,郑 琳.血清CEA、CCR3、CXCL16与Ⅰ期非小细胞肺癌术后复发转移的关系[J].,2023,(14):2666-2671 |
| 血清CEA、CCR3、CXCL16与Ⅰ期非小细胞肺癌术后复发转移的关系 |
| Relationship between Serum CEA, CCR3, CXCL16 and Postoperative Recurrence and Metastasis of Stage I Non-Small Cell Lung Cancer |
| 投稿时间：2023-03-20 修订日期：2023-04-14 |
| DOI：10.13241/j.cnki.pmb.2023.14.012 |
| 中文关键词: Ⅰ期非小细胞肺癌 CEA CCR3 CXCL16 复发转移 |
| 英文关键词: Stage I non-small cell lung cancer CEA CCR3 CXCL16 Recurrence and metastasis |
| 基金项目:江苏省医学重点学科（实验室）建设项目（ZDXKA2016021） |
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| 中文摘要: |
| 摘要 目的：探讨血清癌胚抗原（CEA）、C-C基序趋化因子受体3（CCR3）、C-X-C趋化因子配体16（CXCL16）与Ⅰ期非小细胞肺癌（NSCLC）术后复发转移的关系。方法：选取2015年1月～2017年6月南京医科大学附属南京医院收治的186例接受手术切除的Ⅰ期NSCLC患者为NSCLC组，根据术后是否发生复发转移分为复发转移组和未复发转移组，另选取60名健康体检者为对照组。采用酶联免疫吸附法检测血清CEA、CCR3和CXCL16水平，分析其与Ⅰ期NSCLC患者病理特征的关系。采用多因素Cox回归分析Ⅰ期NSCLC患者术后复发转移的影响因素，采用受试者工作特征（ROC）曲线分析血清CEA、CCR3和CXCL16对Ⅰ期NSCLC患者术后复发转移的预测价值。结果：与对照组比较，NSCLC组血清CEA、CCR3和CXCL16水平升高（P＜0.05）。血清CEA、CCR3和CXCL16水平与Ⅰ期NSCLC患者肿瘤直径、分化程度和TNM分期有关（P＜0.05）。随访5年，失访5例，181例Ⅰ期NSCLC患者术后复发转移为20.99%。多因素Cox回归分析显示，肿瘤直径≥2 cm、低分化、TNM分期ⅠB期和CEA、CCR3、CXCL16升高为Ⅰ期NSCLC患者术后复发转移的独立危险因素（P＜0.05）。ROC曲线分析显示，血清CEA、CCR3和CXCL16联合预测Ⅰ期NSCLC患者术后复发转移的曲线下面积（AUC）大于CEA、CCR3和CXCL16单独预测。结论：血清CEA、CCR3和CXCL16水平升高与Ⅰ期NSCLC患者术后复发转移独立相关，血清CEA、CCR3、CXCL16联合预测Ⅰ期NSCLC患者术后复发转移的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum carcinoembryonic antigen (CEA), C-C motif chemokine receptor 3 (CCR3), C-X-C motif chemokine ligand 16 (CXCL16) and postoperative recurrence and metastasis of stage I non-small cell lung cancer (NSCLC). Methods: 186 patients with stage I NSCLC who underwent surgical resection from January 2015 to June 2017 in Nanjing Hospital Affiliated to Nanjing Medical University were selected as NSCLC group, and they were divided into recurrence and metastasis group and non-recurrence and metastasis group according to postoperative recurrence and metastasis, and 60 healthy subjects were selected as control group. Serum CEA, CCR3 and CXCL16 levels were detected by enzymolinked immunosorbent assay (ELISA), the relationship between them and pathological features of patients with stage I NSCLC were analyzed. Multivariate Cox regression was used to analyze the influencing factors of postoperative recurrence and metastasis in patients with stage I NSCLC. The predictive value of serum CEA, CCR3 and CXCL16 for postoperative recurrence and metastasis in patients with stage I NSCLC was analyzed by receiver operating characteristic (ROC) curve. Results: Compared with the control group, serum CEA, CCR3 and CXCL16 levels in the NSCLC group elevated(P＜0.05). Serum CEA, CCR3 and CXCL16 levels were correlated with tumor diameter, degree of differentiation and TNM stage in patients with stage I NSCLC(P＜0.05). After 5 years of follow-up, 5 patients were lost to follow-up, and 20.99% of 181 patients with stage I NSCLC had postoperative recurrence and metastasis. Multivariate Cox regression analysis showed that tumor diameter ≥2 cm, low differentiation, TNM stage ⅠB and elevated CEA, CCR3 and CXCL16 were independent risk factors for postoperative recurrence and metastasis in patients with stage I NSCLC(P＜0.05). ROC curve analysis showed that the combined prediction of CEA, CCR3 and CXCL16 for postoperative recurrence and metastasis of patients with stage I NSCLC was greater than that of CEA, CCR3 and CXCL16 alone. Conclusion: Elevated the serum CEA, CCR3 and CXCL16 levels are independently associated with postoperative recurrence and metastasis in patients with stage I NSCLC, and the combination of serum CEA, CCR3 and CXCL16 has a high value in predicting postoperative recurrence and metastasis in patients with stage I NSCLC. |
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