| 梁 军,任 璐,陶 琳,陈 华,康淑芳.基于P-mTOR/mTOR通路探讨来曲唑片联合益母草颗粒对多囊卵巢综合征患者的作用及其机制研究[J].,2023,(13):2582-2585 |
| 基于P-mTOR/mTOR通路探讨来曲唑片联合益母草颗粒对多囊卵巢综合征患者的作用及其机制研究 |
| Study on the Effect and Its mechanism of Letrozole Tablets Combined with Motherwort Granules on Patients with Polycystic Ovarian Syndrome Based on P-mTOR/mTOR Pathway |
| 投稿时间：2023-02-06 修订日期：2023-02-27 |
| DOI：10.13241/j.cnki.pmb.2023.13.037 |
| 中文关键词: P-mTOR/mTOR通路 来曲唑片 益母草颗粒 多囊卵巢综合征 作用机制 |
| 英文关键词: P-mTOR/mTOR pathway Letrozole tablets Motherwort granules Polycystic ovarian syndrome Effect and mechanism |
| 基金项目:山东省中医药科技发展计划项目（2019-0134） |
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| 中文摘要: |
| 摘要 目的：基于磷酸化雷帕霉素靶蛋白（P-mTOR）/雷帕霉素靶蛋白（mTOR）通路探讨来曲唑片联合益母草颗粒对多囊卵巢综合征（PCOS）患者的作用及其机制研究。方法：选取2021年4月至2022年8月期间济南市第二妇幼保健院收治的142例PCOS患者，按照随机数字表法将患者分为对照组（接受来曲唑片治疗，n=71）和研究组（接受来曲唑片联合益母草颗粒治疗，n=71）。对比两组性激素指标、空腹血糖（FPG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、血清P-mTOR、mTOR水平。结果：两组治疗3个月后黄体生成素（LH）、雌二醇（E2）、睾酮（T）下降，促卵泡激素（FSH）上升，且研究组的LH、E2、T低于对照组，FSH高于对照组（P<0.05）。两组治疗3个月后FPG、HOMA-IR、FINS下降，且研究组低于对照组（P<0.05）。两组治疗3个月后血清P-mTOR及mTOR水平下降，且研究组低于对照组（P<0.05）。结论：益母草颗粒、来曲唑片联合治疗可能通过调控P-mTOR/mTOR通路改善PCOS患者的性激素、血糖水平及胰岛素抵抗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect and its mechanism of letrozole tablets combined with motherwort granules on patients with polycystic ovary syndrome (PCOS) based on phosphorylated-mammalian target of rapamycin (P-mTOR)/mammalian target of rapamycin (mTOR) pathway. Methods: 142 patients with PCOS who were admitted to Jinan Second Maternal and Child Health Hospital from April 2021 to August 2022 were selected, and they were divided into control group(receiving letrozole tablets, n=71) and study group (receiving letrozole tablets combined with motherwort granules, n=71) according to random number table method. Sex hormone indexes, Fasting plasma glucose (FPG), fasting insulin (FINS), insulin resistance index (HOMA-IR), serum P-mTOR and mTOR levels were compared in the two groups. Results: 3 months after treatment, luteinizing hormone (LH), estradiol (E2) and testosterone (T) in the two groups decreased, while follicle-stimulating hormone (FSH) increased. LH, E2 and T in the study group were lower than those in the control group, and FSH was higher than that in the control group (P<0.05). FPG, HOMA-IR and FINS in the two groups at 3 months after treatment decreased, and the study group was lower than the control group (P<0.05). Serum P-mTOR and mTOR levels in the two groups at 3 months after treatment decreased, and the study group was lower than the control group(P<0.05). Conclusion: The combination of motherwort granules and letrozole tablets may improve the sex hormones, blood glucose levels and insulin resistance in patients with PCOS by regulating P-mTOR/mTOR pathway. |
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