| 王海峰,江 巍,赵炜祎,刘志宏,王燕芳.血清NLR、GDF-15及TRPC1与老年心力衰竭患者相关性分析[J].,2023,(13):2503-2507 |
| 血清NLR、GDF-15及TRPC1与老年心力衰竭患者相关性分析 |
| Correlation between Serum NLR, GDF-15, TRPC1 and Elderly Patients with Heart Failure |
| 投稿时间：2022-12-12 修订日期：2022-12-28 |
| DOI：10.13241/j.cnki.pmb.2023.13.020 |
| 中文关键词: 中性粒细胞 淋巴细胞 生长分化因子-15 瞬时受体电位通道1 心力衰竭 相关性 |
| 英文关键词: Neutrophil Lymphocytes Growth differentiation factor-15 Transient receptor potential channel 1 Heart failure Relevance |
| 基金项目:内蒙古自治区自然科学基金项目（2017MS(LH)0848） |
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| 中文摘要: |
| 摘要 目的：探讨血清中性粒细胞与淋巴细胞比值（NLR）、生长分化因子-15（GDF-15）及瞬时受体电位通道1（TRPC1）与老年心力衰竭患者相关性。方法：选取我院2020年1月到2022年10月收治的100例老年慢性心力衰竭患者作为研究对象，将其分为心力衰竭组，另选取同期来我院体检的101名健康老年人作为对照组，98例心律失常老年患者作为心律失常组，对比三组受检者血清NLR、GDF-15及TRPC1水平，并应用受试者工作（ROC）曲线分析血清NLR、GDF-15及TRPC1对老年慢性心力衰竭的诊断价值。并依照NYHA心功能分级标准对100例心力衰竭患者进行评价，其中Ⅱ级23例，Ⅲ级38例，Ⅳ级39例，对比不同心功能分级患者血清NLR、GDF-15及TRPC1表达水平，应用Spearman相关分析分析血清NLR、GDF-15及TRPC1与老年心力衰竭患者心功能的相关性。结果：三组受检者血清NLR、GDF-15及TRPC1水平对比差异显著，心力衰竭组明显高于心律失常组和对照组（P＜0.05）；通过绘制ROC曲线，分析表1中组间具有明显差异的指标，确定其对老年心力衰竭的诊断效能，结果显示，曲线下面积（AUC）从依次为NLR（0.688）、GDF-15（0.667）、TRPC1（0.656）、三者联合（0.671）。NLR诊断灵敏度为67.61 %，特异度为66.85 %，GDF-15诊断灵敏度为60.03 %，特异度为67.53 %，TRPC1诊断灵敏度为61.24 %，特异度为66.53 %，三者联合诊断灵敏度为74.58 %，特异度为86.32 %；不同级别心功能的心力衰竭患者血清NLR、GDF-15及TRPC1水平对比差异显著，Ⅳ级心功能明显高于Ⅲ级、Ⅱ级（P＜0.05）；Spearman相关分析结果显示：NLR、GDF-15及TRPC1水平与老年心力衰竭患者心功能呈正相关（P＜0.05）。结论：血清NLR、GDF-15及TRPC1三者联合对于老年心力衰竭诊断灵敏度和特异度较高，且与患者心功能具有明显相关性，临床可考虑应用NLR、GDF-15及TRPC1作为超声心动图补充诊断手段，为临床诊断提供参考意见。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum neutrophil lymphocyte ratio (NLR), growth differentiation factor-15 (GDF-15) and transient receptor potential channel 1 (TRPC1) in elderly patients with heart failure. Methods: 100 elderly patients with chronic heart failure admitted to our hospital from January 2020 to October 2022 were selected as the research objects, and they were divided into heart failure group. In addition, 101 healthy elderly people who came to our hospital for physical examination at the same time were selected as the control group, and 98 elderly patients with arrhythmia were selected as the arrhythmia group. The serum NLR, GDF-15 and TRPC1 levels of the three groups were compared, and the serum NLR Diagnostic value of GDF-15 and TRPC1 in elderly patients with chronic heart failure. 100 patients with mental failure were evaluated according to NYHA cardiac function grading standard, including 23 patients with grade II, 38 patients with grade III, and 39 patients with grade IV. The expression levels of serum NLR, GDF-15, and TRPC1 in patients with different concentric function grading were compared. The correlation between serum NLR, GDF-15, and TRPC1 and heart function in elderly patients with heart failure was analyzed by Spearman correlation analysis. Results: The levels of serum NLR, GDF-15 and TRPC1 in the three groups were higher than those in the arrhythmia group and the control group (P<0.05); By drawing ROC curve and analyzing the indicators with differences between groups in Table 1, the diagnostic efficacy of ROC in elderly heart failure was determined. The results showed that the area under the curve (AUC) was NLR (0.688), GDF-15 (0.667), TRPC1 (0.656), and the combination of the three (0.671). The diagnostic sensitivity of NLR was 67.61 %, the specificity was 66.85 %, the diagnostic sensitivity of GDF-15 was 60.03 %, the specificity was 67.53 %, the diagnostic sensitivity of TRPC1 was 61.24%, the specificity was 66.53 %, the combined diagnostic sensitivity of the three was 74.58 %, the specificity was 86.32 %; The levels of serum NLR, GDF-15 and TRPC1 in patients with heart failure at different levels were different, and the level of IV cardiac function was significantly higher than that of III, II(P<0.05); Spearman correlation analysis showed that the levels of NLR, GDF-15 and TRPC1 were positively correlated with cardiac function in elderly patients with heart failure(P<0.05). Conclusion: The combination of serum NLR, GDF-15 and TRPC1 has a high sensitivity and specificity for the diagnosis of senile heart failure, and has a significant correlation with the cardiac function of patients. The clinical application of NLR, GDF-15 and TRPC1 can be considered as supplementary diagnostic means of echocardiography, providing reference for clinical diagnosis. |
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