| 赵 静,史鹏翔,孙津龙,王 峰,李金玉,惠秀丽,王泽辉.血糖控制水平与2型糖尿病患者根尖周病的相关关系研究[J].,2023,(13):2434-2438 |
| 血糖控制水平与2型糖尿病患者根尖周病的相关关系研究 |
| Study on the Relationship between Blood Glucose Control Level and Periapical Disease in Type 2 Diabetes Mellitus |
| 投稿时间：2022-12-21 修订日期：2023-01-17 |
| DOI：10.13241/j.cnki.pmb.2023.13.007 |
| 中文关键词: 2型糖尿病 根尖周病 血糖控制 糖化血红蛋白 |
| 英文关键词: Type 2 diabetes mellitus Periapical disease Blood glucose control Glycosylated hemoglobin |
| 基金项目:国家自然科学基金项目（81800939）；装备军内科研计划项目（HJ20172A05389） |
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| 中文摘要: |
| 摘要 目的：探讨血糖控制水平与2型糖尿病合并根尖周病的相关性。方法：回顾性选择2018年9月～2022年9月我院收治的300例2型糖尿病患者临床资料，根据是否发生根尖周病将患者分为根尖周病组（45例）和对照组（255例），根据糖化血红蛋白（HbA1c）分为血糖控制不佳组（HbA1c≥6.5%，105例），血糖控制良好组（HbA1c＜6.5%，195例）。多因素Logistic回归分析2型糖尿病合并根尖周病的相关因素，受试者工作特征曲线（ROC）分析HbA1c诊断2型糖尿病合并根尖周病的价值。结果：血糖控制不佳组根尖周病发病率（28.57% vs 7.69%）、PAI评分（2.66±0.41分 vs1.24±0.26分）均高于血糖控制良好组（P＜0.001）。根尖周病组吸烟史比例、牙周疾病比例、血糖控制不佳比例、FPG高于对照组（P＜0.001），2型糖尿病病程长于对照组（P＜0.001），服用二甲双胍比例低于对照组（P＜0.01）。多因素Logistic回归结果显示血糖控制不佳、吸烟史是2型糖尿病患者合并根尖周病的危险因素（P＜0.001，P＜0.01），服用二甲双胍是保护因素（P＜0.001）。HbA1c诊断2型糖尿病患者合并根尖周病的曲线下面积为0.659（95%CI：0.650-0.756， P＜0.01），灵敏度为73.33%，特异度为62.75%，约登指数为0.3608。结论：血糖控制不佳可能与2型糖尿病患者根尖周病的发生有关，临床应积极控制血糖水平以阻止根尖周病的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between blood glucose control level and type 2 diabetes mellitus complicated with periapical disease. Methods: Clinical data of 300 patients with type 2 diabetes who were admitted to our hospital from September 2018 to September 2022 were retrospectively selected. According to the occurrence of periapical disease, patients were divided into periapical disease group (45 cases) and control group (255 cases). According to HbA1c, patients were divided into poor blood glucose control group (HbA1c≥6.5%, 105 cases), good blood glucose control group (HbA1c < 6.5%, 195 cases). Multivariate Logistic regression analyzed the related factors of type 2 diabetes mellitus with periapical disease, receiver operating characteristic curve (ROC) analyzed the diagnostic value of type 2 diabetes mellitus with periapical disease by HbA1c. Results: The incidence of periapical disease (28.57% vs 7.69%) and PAI score (2.66±0.41 vs1.24±0.26) in poor blood glucose control group were higher than those in good blood glucose control group(P<0.001). The proportion of smoking history, periodontal disease, poor blood glucose control and FPG in periapical disease group was higher than that in control group(P<0.001), the course of type 2 diabetes mellitus was longer than that in control group (P<0.001), and the proportion of taking metformin was lower than that in control group(P<0.01). Multivariate Logistic regression showed that poor blood glucose control and smoking history were risk factors for periapical disease in type 2 diabetic patients (P<0.001, P<0.01), while metformin use was protective factor (P<0.001). The area under the curve of HbA1c for the diagnosis of type 2 diabetes patients with periapical disease was0.659（95%CI: 0.650-0.756, P＜0.01）, the sensitivity was 73.33%, the specificity was 62.75%, and the Jordon index was 0.3608. Conclusion: Poor blood glucose control is related to the occurrence of periapical disease in patients with type 2 diabetes mellitus, and blood glucose level should be actively controlled to prevent periapical disease. |
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