| 王继轩,许华山,张 恩,杨永春,李 进.精神分裂症患者血清α-synuclein、MT水平与睡眠质量、昼夜节律偏好以及认知功能损害的关系研究[J].,2023,(12):2382-2386 |
| 精神分裂症患者血清α-synuclein、MT水平与睡眠质量、昼夜节律偏好以及认知功能损害的关系研究 |
| Relationship Study between Serum α-Synuclein and MT Levels and Sleep Quality, Circadian Rhythm Preference and Cognitive Function Impairment in Patients with Schizophrenia |
| 投稿时间：2022-12-07 修订日期：2022-12-27 |
| DOI：10.13241/j.cnki.pmb.2023.12.034 |
| 中文关键词: 精神分裂症 α-突触核蛋白 褪黑素 睡眠质量 昼夜节律偏好 认知功能 |
| 英文关键词: Schizophrenia α-synuclein Melatonin Sleep quality Circadian rhythm preference Cognitive function impairment |
| 基金项目:国家级大学生创新训练项目（202210367020） |
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| 摘要 目的：研究精神分裂症患者血清α-突触核蛋白（α-synuclein）、褪黑素（MT）水平与睡眠质量、昼夜节律偏好以及认知功能损害的关系。方法：将芜湖市第四人民医院从2020年1月-2021年1月治疗的118例精神分裂症患者纳入研究，记作观察组。另取同期健康体检人员80例作为对照组。检测并比较两组人员的血清α-synuclein、MT水平，并对比两组人员的睡眠质量、昼夜节律偏好以及认知功能损害情况。以Pearson相关性分析血清α-synuclein、MT水平与匹兹堡睡眠质量指数（PSQI）、早晚问卷（MEQ）、阳性与阴性症状量表（PANSS）评分、认知功能成套测验共识版（MCCB）的关系。结果：观察组血清α-synuclein、MT水平低于对照组（均P＜0.05）。观察组PSQI各项评分及总分均高于对照组（均P＜0.05）。观察组绝对夜晚型、中间夜晚型人数占比高于对照组，而中度清晨型、绝对清晨型人数占比低于对照组（均P＜0.05），观察组MEQ总分低于对照组（P＜0.05）。观察组MCCB各项评分及总分均低于对照组（均P＜0.05）。经Pearson相关性分析可得：血清α-synuclein、MT水平与PSQI总分、PANSS评分呈负相关，而与MEQ、MCCB总分呈正相关（均P＜0.05）。结论：精神分裂症患者血清α-synuclein、MT水平降低，且与睡眠质量、昼夜节律偏好以及认知功能损害密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum α-synuclein (α-synuclein) and melatonin (MT) levels and sleep quality, circadian rhythm preference and cognitive function impairment in patients with schizophrenia. Methods: 118 patients with schizophrenia who were treated to the Wuhu Fourth People's Hospital from January 2020 to January 2021 were included in the study and classified as the observation group. 80 healthy people as the control group. Serum α-synuclein and MT levels were detected and compared between the two groups, and the sleep quality, circadian rhythm preference and cognitive function impairment were compared between the two groups. Pearson correlation analyze the relationship between serum α-synuclein and MT levels and Morning and Evening Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI), Positive and Negative Symptoms Scale (PANSS) scores, and Consensus Version of the Cognitive Function Complete Test (MCCB). Results: The serum α-synuclein and MT levels in observation group were lower than those in control group (all P＜0.05). The scores and total scores of PSQI in observation group were higher than those in control group (all P＜0.05). The proportion of absolute night type and middle night type in the observation group were higher than those in the control group, while the proportion of moderate morning type and absolute morning type were lower than those in the control group (all P＜0.05). The total score of MEQ in the observation group was lower than that in the control group (P＜0.05). The MCCB scores and total scores in observation group were lower than those in control group (all P＜0.05). According to Pearson correlation analysis, serum α-synuclein and MT levels were negatively correlated with PSQI total score and PANSS score, while positively correlated with MEQ and MCCB total score (all P＜0.05). Conclusion: Serum α-synuclein and MT levels are decreased in patients with schizophrenia, which are closely related to sleep quality, circadian rhythm preference and cognitive function impairment. |
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